Osteoarticular Tuberculosis

Tuberculosis of the bones or joints.

Also Known As:

Tuberculosis, Osteoarticular; Bone Tuberculoses; Joint Tuberculoses; Osteoarticular Tuberculoses; Tuberculoses, Bone; Tuberculoses, Joint; Tuberculoses, Osteoarticular; Tuberculosis, Bone; Tuberculosis, Joint; Bone Tuberculosis; Joint Tuberculosis

Networked: 522 relevant articles (5 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Tuberculosis (Tuberculoses)
3.	Extrapulmonary Tuberculosis
4.	Infections
5.	Meningeal Tuberculosis (Tuberculous Meningitis)

Experts

1.	Agarwal, Anil: 7 articles (01/2017 - 10/2009)
2.	Harinath, B C: 4 articles (04/2003 - 08/2000)
3.	Huang, Hairong: 3 articles (01/2022 - 07/2013)
4.	Qin, Shibing: 3 articles (01/2022 - 07/2013)
5.	Li, Dawei: 3 articles (03/2017 - 06/2015)
6.	Ma, Yuanzheng: 3 articles (03/2017 - 06/2015)
7.	Shen, Hong: 3 articles (03/2017 - 06/2015)
8.	Wu, Decheng: 3 articles (03/2017 - 06/2015)
9.	Yang, Fei: 3 articles (03/2017 - 06/2015)
10.	Dabla, Pradeep Kumar: 3 articles (01/2017 - 12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteoarticular Tuberculosis:

1.	Isoniazid (Ftivazide)FDA LinkGeneric 05/01/1955 - "[Osteoarticular tuberculosis and isonicotinic acid hydrazide]." 12/08/1954 - "[Treatment of osteoarticular tuberculosis with isoniazid]." 07/01/1954 - "[Isonicotinic acid hydrazide in the treatment of osteoarticular tuberculosis]." 06/12/1954 - "Isoniazid in treatment of bone and joint tuberculosis; a review of 20 cases." 02/01/1954 - "[Osteoarticular tuberculosis treated with isonicotinic acid hydrazide]."
2.	IproniazidIBA 10/01/1956 - "[Iproniazid for bone and joint tuberculosis]." 07/01/1953 - "The use of iproniazid in the treatment of bone and joint tuberculosis." 01/01/1955 - "A comparison of the efficacy of iproniazid (marsilid) and isoniazid (rimifon) in the treatment of bone and joint tuberculosis."
3.	SolutionsIBA 10/01/1978 - "A final solution of the problem of the osteoarticular tuberculosis is to be expected above all within the general combat against tuberculosis." 12/01/2009 - "At postoperative year one, the mean FAOS for pain improved to 85 from 26, whereas the mean FAOS for quality of life improved to 60 from 5. Tibiotalocalcaneal arthrodesis using a supracondylar femoral nail, combined with debridement and multidrug therapy, enabled a reliable one-stage solution for advanced osteoarticular tuberculosis and early return to function."
4.	lipoarabinomannan (LAM)IBA 03/01/2013 - "The patients with a history of osteoarticular tuberculosis tend to show positive results of QFT-2-G test for a prolonged period, whereas significantly less positive results of TBGL/LAM tests in mid-long-term." 03/01/2013 - "To evaluate results of QFT-2G/TBGL/ LAM in patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis with various periods after the completion of the treatment, Fifty-five patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis at least one year after the completion of treatment were evaluated using QFT-2G/TBGL/LAM tests. " 03/01/2013 - "[Evaluation using QFT-2G/TBGL/LAM in the patients with osteoarticular tuberculosis of post-treatment period]." 02/01/1990 - "The serum antibody to lipoarabinomannan-B(LAM-B) purified from mycobacterium tuberculosis (H37Ra) was tested by ELISA in 250 sera, including sera from patients as follows: tuberculosis 96, tubercular pleurisy 11, renal tuberculosis 2, bone and joint tuberculosis 33, tubercular meningitis 16, pulmonary cancer 22, leprosy 20 and normal subjects 50. "
5.	Streptomycin (Streptomycin Sulfate)FDA Link 01/18/1954 - "[Evaluation of action of streptomycin in certain forms of osteoarticular tuberculosis in children according to microscopic and bacteriologic studies]." 01/01/1952 - "Studies on the concentration of streptomycin the treatment of bone and joint tuberculosis." 07/01/1994 - "The first use of streptomycin for bone tuberculosis: a 47-year follow-up." 11/01/1964 - "[INTRAOSEOUS INJECTION OF STREPTOMYCIN IN THE TREATMENT OF OSTEOARTICULAR TUBERCULOSIS]." 07/01/1959 - "[Streptomycin, phthivasid and their combination in the treatment of experimental osteoarticular tuberculosis induced in rabbits by streptomycin sensitive and resistant Mycobacterium tuberculosis]."
6.	Rifampin (Rifampicin)FDA LinkGeneric 12/03/2014 - "Several studies have shown that the intralesional concentration of rifampicin in osteoarticular tuberculosis is typically at a subtherapeutic level. " 08/01/1973 - "[Clinical studies on the effects of rifampicin for bone and joint tuberculosis (author's transl)]." 03/01/1973 - "[Clinical studies on the effects of rifampicin for severe bone and joint tuberculosis]." 12/03/2014 - "Rifampicin MIC test in rifampicin-resistant isolates from patients with osteoarticular tuberculosis." 03/01/1973 - "[The effects of rifampicin on bone-joint tuberculosis with fistulation]."
7.	Blood Proteins (Serum Proteins)IBA 07/01/2023 - "This study provides a reference for the discovery of serum protein markers for osteoarticular tuberculosis diagnosis, and the screened DEPs can also provide directions for subsequent pathogenesis research." 09/01/1964 - "[ELECTROPHORETIC STUDIES ON SERUM PROTEIN FRACTIONS IN VARIOUS STAGES OF OSTEOARTICULAR TUBERCULOSIS IN RABBITS]." 01/01/1964 - "[CHANGES OF SERUM PROTEIN FRACTIONS IN CHILDREN WITH OSTEOARTICULAR TUBERCULOSIS]." 06/01/1961 - "[The blood protein level in children with osteoarticular tuberculosis]." 01/01/1959 - "[Blood proteins changes in bone tuberculosis]."
8.	Biomarkers (Surrogate Marker)IBA 07/01/2023 - "This study aims to search serum biomarkers that can assist in the diagnosis of osteoarticular tuberculosis. " 01/01/2022 - "Novel Potential Diagnostic Serum Biomarkers of Metabolomics in Osteoarticular Tuberculosis Patients: A Preliminary Study." 07/01/2023 - "Several potential serum proteomic biomarkers for diagnosis of osteoarticular tuberculosis based on mass spectrometry." 01/01/2022 - "Liquid chromatography tandem mass spectrometry (LC-MS/MS) was used to detect and analyze metabolites in the serum with osteoarticular tuberculosis patients, disease controls, and healthy controls to find novel metabolic biomarkers that could be used in the diagnosis of osteoarticular tuberculosis. " 07/01/2020 - "Screening and identification of serum biomarkers of osteoarticular tuberculosis based on mass spectrometry."
9.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2020 - "Long term multiple systemic antibiotics form the cornerstone in the treatment of bone and joint tuberculosis, often combined with local surgical eradication. " 01/01/1964 - "[THE FREQUENCY OF ANTIBIOTIC-RESISTANT TUBERCLE BACILLI IN BONE AND JOINT TUBERCULOSIS]." 07/01/1961 - "[Modifications in the anatomopathological lesions of osseous and osteoarticular tuberculosis under the influence of antibiotic treatment. " 08/15/1958 - "[Osteoarticular tuberculosis and antibiotics]." 07/01/1957 - "[Antibiotic treatment of osteoarticular tuberculosis; bacteriological observations]."
10.	Proteins (Proteins, Gene)FDA Link 05/01/1954 - "[Osteoarticular tuberculosis and its relation to protein fractions; Antweiler's microelectrophoretic method]." 01/01/1950 - "[Protein changes in the course of osteoarticular tuberculosis]." 01/01/1958 - "[Study of serum proteins in osteoarticular tuberculosis by electrophoresis; pursuing the course of bone and tuberculotic processes and effect of surgery on protein fractions]." 07/01/2016 - "Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis." 01/01/1964 - "[SIGNIFICANCE OF TUBERCULIN DIAGNOSIS AND EXAMINATION OF PROTEIN FRACTIONS IN THE BLOOD SERUM IN SURGICAL TREATMENT OF OSTEOARTICULAR TUBERCULOSIS]."

Therapies and Procedures

1.	Therapeutics 01/01/2009 - "Pathology has revealed bone tuberculosis and antibacillary therapy was initiated with good results. " 04/01/2016 - "*Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy. " 01/01/1961 - "[Clinical aspects and therapy of bone tuberculosis in the light of electrophoretic studies]." 09/01/1954 - "[Role of hematological studies in diagnosis and therapy of osteoarticular tuberculosis]." 10/01/2022 - "Historically, osteoarticular tuberculosis (TB), including spinal TB, was treated with prolonged course of antitubercular therapy (ATT). "
2.	Drug Therapy (Chemotherapy) 04/01/2011 - "Both exudative and dependent forms of suppurative presentations of osteoarticular tuberculosis responded well to standard antitubercular chemotherapy. " 07/01/2022 - "The treatment of osteoarticular tuberculosis is primary medical with antituberculosis chemotherapy. " 10/01/2021 - "We report two patients of AC joint tuberculosis, treated with multidrug chemotherapy resulting in a good functional outcome." 03/28/2017 - "Currently, the major issues in the treatment of osteoarticular tuberculosis (TB) after implant placement are low drug concentration at the infected focus and drug resistance resulting from the long-term chemotherapy. " 09/14/2015 - "To cure serious bone tuberculosis, a novel long-term drug delivery system was designed and prepared to satisfy the needs of both bone regeneration and antituberculous drug therapy. "
3.	Debridement 03/01/2020 - "This study aimed to develop and evaluate a sustained drug delivery system for the treatment of osteoarticular tuberculosis (TB) to address the issues surrounding low drug concentration in lesions and bone defects or nonunion after debridement. " 04/01/2023 - "One-stage debridement and fusion is proven efficacious for end-stage joint tuberculosis, with less surgery occasion compared with staged surgery. " 01/01/1957 - "End results of focal debridement in bone and joint tuberculosis and its indications." 01/01/2005 - "Studies that focus on inflammatory OA, joint tuberculosis, septic joints, psoriatic joints (e.g., psoriatic knee joint synovitis), synovitis, chondropathy of the knee and gonarthrosis (which includes varotic gonarthrosis)Studies that focus on rheumatoid arthritisStudies that focus on meniscal tears from an acute injury (e.g., sports injury)Studies that are based on lavage or debridement for microfracture of the kneeStudies in which other surgical procedures (e.g., high tibial osteotomy, synovectomy, have been conducted in addition to lavage/debridement)Studies based on malalignment of the knee (e.g., varus/valgus arthritic conditions).Studies that compare lavage to lavage plus drug therapyStudies on procedures that are not arthroscopic (i.e., visually guided) (e.g., nonarthroscopic lavage)Studies of OA in children. " 12/01/2009 - "At postoperative year one, the mean FAOS for pain improved to 85 from 26, whereas the mean FAOS for quality of life improved to 60 from 5. Tibiotalocalcaneal arthrodesis using a supracondylar femoral nail, combined with debridement and multidrug therapy, enabled a reliable one-stage solution for advanced osteoarticular tuberculosis and early return to function."
4.	Arthrodesis 09/01/1956 - "[Arthrodesis in the treatment of osteoarticular tuberculosis]." 04/18/1952 - "[Arthrodesis in osteoarticular tuberculosis]." 01/01/1950 - "[Technic in arthrodesis in osteoarticular tuberculosis]." 12/01/2009 - "At postoperative year one, the mean FAOS for pain improved to 85 from 26, whereas the mean FAOS for quality of life improved to 60 from 5. Tibiotalocalcaneal arthrodesis using a supracondylar femoral nail, combined with debridement and multidrug therapy, enabled a reliable one-stage solution for advanced osteoarticular tuberculosis and early return to function."
5.	Microspheres (Microsphere) 01/01/2014 - "Comparing microspheres with different internal phase of polyelectrolyte as local drug delivery system for bone tuberculosis therapy." 01/01/2019 - "Isoniazid-loaded chitosan/carbon nanotubes microspheres promote secondary wound healing of bone tuberculosis." 04/01/2017 - "Effect of bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres on bone and joint tuberculosis in vitro." 01/01/2015 - "The study was to develop and evaluate the rifapentine-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres (RPMs) for the treatment of osteoarticular tuberculosis to avoid critical side effects caused by oral regimens of antibiotics or intravenous antibiotics. "