Cutaneous Tuberculosis (Scrofuloderma)

04/14/2022 - "This communication describes an immunocompetent patient diagnosed with GC resulting from tuberculid, who responded well to Isoniazid monotherapy."
11/01/1953 - "[Clinical, experimental and histological studies on the treatment of cutaneous tuberculosis with isonicotinic acid hydrazide]."
07/03/2012 - "Cutaneous tuberculosis caused by isoniazid-resistant Mycobacterium tuberculosis."
05/01/1958 - "[Liver damage in isoniazid treatment of cutaneous tuberculosis]."
01/01/1958 - "[Experiences with isoniazid treatment of cutaneous tuberculosis in the Lodz Military Academy Dermatological Clinic]."

04/01/1989 - "A case of penis tuberculid (papulonecrotic tuberculid of the glans penis) and its treatment with combination of oral rifampicin (RFP) and injection of an extract from tubercle bacilli (T.B. "
04/01/1989 - "Penis tuberculid (papulonecrotic tuberculid of the glans penis): treatment with a combination of rifampicin and an extract from tubercle bacilli (T.B. "
01/01/2021 - "Individuals with cutaneous tuberculosis (CTB) were found to have significantly higher IFI44L expression after 6 months of rifampicin therapy than after only 1 month. "
10/19/2017 - "On investigation, she was found to have rifampicin-sensitive tuberculosis presenting as tubercular gumma, a rare form of cutaneous tuberculosis which occurs due to haematogenous spread of the bacilli. "
10/01/2006 - "A daily regimen of rifampicin and isoniazid for 9 months was effective in treating cutaneous tuberculosis."

03/01/2017 - "Preferentially, young adults in developing or low-income countries are affected from cutaneous tuberculosis, which usually occurs in previously sensitized persons with a high degree of tuberculin sensitivity and a good immunoresponse. "
01/01/2015 - "The authors report a case of cutaneous tuberculosis in a 63-year-old female patient, who had an infiltrated, erythematous-ferruginous plaque of indurated aspect on her right leg and a nonreactive PPD skin test. "
01/01/2015 - "Cutaneous tuberculosis with nonreactive PPD skin test: a diagnostic challenge."
03/01/1979 - "[Significance of tuberculin reactions in the diagnosis of skin tuberculosis]."
01/01/1958 - "[Ulcerated glummatous lesion of the scrofuloderma type following a BCG vaccination at the level of the previously practiced tuberculin test]."

01/01/2016 - "Interferon-γ Release Assay and Reverse Blot Hybridization Assay: Diagnostic Role in Cutaneous Tuberculosis."
03/01/2012 - "Bacterial cultures are the gold standard for diagnosing cutaneous tuberculosis, but there are limitations, despite the advances embracing the innovative technologies, including interferon yrelease assays, enzyme-linked immunoabsorbant assay, and molecular diagnostics, in addition to conventional skin tests and microscopic pathology. "
05/01/2011 - "The aim of this study was to evaluate the diagnostic performance of an enzyme-linked immunospot (ELISPOT) assay (T-SPOT.TB; Oxford Immunotec, Oxford, UK) for interferon-γ in patients with suspected cutaneous tuberculosis (TB). "
05/01/2011 - "Diagnostic value of an enzyme-linked immunospot assay for interferon-γ in cutaneous tuberculosis."
01/01/2020 - "There are several findings that support diagnosis of a tuberculid, including failure to detect mycobacterium TB in stains or cultures of affected tissue, frequent resolution of skin lesions with anti-TB therapy, a strongly positive tuberculin skin test, a positive interferon-γ release assay, presence of an endogenous TB infection, and granulomatous tissue present in histopathology. "

01/01/1967 - "[Activity of several blood serum enzymes during treatment of patients with skin tuberculosis]."
03/01/2012 - "Bacterial cultures are the gold standard for diagnosing cutaneous tuberculosis, but there are limitations, despite the advances embracing the innovative technologies, including interferon yrelease assays, enzyme-linked immunoabsorbant assay, and molecular diagnostics, in addition to conventional skin tests and microscopic pathology. "
05/01/2011 - "The aim of this study was to evaluate the diagnostic performance of an enzyme-linked immunospot (ELISPOT) assay (T-SPOT.TB; Oxford Immunotec, Oxford, UK) for interferon-γ in patients with suspected cutaneous tuberculosis (TB). "
05/01/2011 - "Diagnostic value of an enzyme-linked immunospot assay for interferon-γ in cutaneous tuberculosis."
06/01/1970 - "[Effect of antitubercular preparations on the activity of serum enzymes and the level of 5-oxyindoleacetic acid in the urine in patients with cutaneous tuberculosis]."

01/01/2020 - "This study demonstrated improved transdermal delivery of rifampicin-loaded cationic nanoemulsion gel to treat systemic and cutaneous tuberculosis using capmul, labrasol, and acconon, which exert anti-Mycobacterium activities. "

01/01/2020 - "This study demonstrated improved transdermal delivery of rifampicin-loaded cationic nanoemulsion gel to treat systemic and cutaneous tuberculosis using capmul, labrasol, and acconon, which exert anti-Mycobacterium activities. "

01/01/1952 - "A case of skin tuberculosis with a positive Kveim's reaction as late as five years after injection of antigen."
01/01/2021 - "Erythema induratum of Bazin (EIB) is a form of tuberculid resulting from hypersensitivity to tuberculosis antigen. "
10/01/1992 - "However, a diagnostic sensitivity of 50% was achieved in patients with skin tuberculosis on the basis of a high ratio between antibody titres for the whole antigen and its TB23 epitope."
03/01/1993 - "In scrofuloderma, LAM-B antigen was observed only in the granuloma while no other positive findings were noted with other stains. "
11/15/2003 - "The PPD-based IFN-gamma test was very effective in differentiating animals vaccinated against Johne's disease that were skin-test positive from those with bovine tuberculosis, and the use of PPD or specific mycobacterial antigens minimised the number of false positive reactions in animals with skin tuberculosis."

10/01/1961 - "[Studies on C-reactive proteins in cutaneous tuberculosis]."
07/01/1958 - "[Protein fractions of blood serum in the course of skin tuberculosis treatment]."
03/20/2016 - "Our study indicated that the expression of HBD-2 and HBD-3 mRNA and protein in lesions of cutaneous tuberculosis may be not consistent with that of tuberculids. "
03/20/2016 - "The expressions of HBD-3 mRNA and protein in lesions of cutaneous tuberculosis and tuberculids were similar to that of normal skin. "
03/20/2016 - "The expression of HBD-2 mRNA had an increasing trend in the lesions of cutaneous tuberculosis and tuberculids compared with that of normal skin; however, the expression of HBD-2 protein in the lesions of cutaneous tuberculosis had a decreasing trend compared with that of normal skin, and the expression of HBD-2 protein in the lesions of tuberculids was similar to that of normal skin. "

10/01/2009 - "According to authors of the study, the described case confirms the usefulness of PCR nucleonic acids amplification test in cutaneous tuberculosis diagnosis."
01/01/2023 - "Moreover, our case reminds us that it is necessary to conduct repeated culture tests, rather than relying purely on polymerase chain reaction (PCR) results, given that cases of PCR-negative acid-fast bacilli (AFB) culture-positive scrofuloderma have been reported. "
11/01/2020 - "Cutaneous tuberculosis supposes a diagnostic challenge due to its variety of clinical manifestations and the difficulty in demonstrating resistant acid-alcohol bacilli in histological samples. "
01/01/2013 - "Papulonecrotic Tuberculid with Positive Acid-fast Bacilli."
02/01/2012 - "Based on clinical examinations, staining for acid-fast bacilli, and positive findings of polymerase chain reaction, a quick diagnosis of scrofuloderma was made. "

01/01/2022 - "in this study, BacT/Alert3D and response to antitubercular therapy were taken as gold standard and performance of GeneXpertMTB/RIF was evaluated against it in clinically and histopathologically suspected cases of cutaneous tuberculosis. "
05/01/2010 - "Trial of antitubercular therapy in the diagnosis of cutaneous tuberculosis."
07/01/2007 - "Laboratory tests for the diagnosis of cutaneous tuberculosis lack adequate sensitivity and specificity and a trial of therapy is often used as a diagnostic test in difficult cases. "
02/01/2005 - "When a therapeutic trial is undertaken in cutaneous tuberculosis, 6 weeks of therapy with four drugs appears adequate to prove (or disprove) the diagnosis."
02/01/2005 - "Information is lacking on the response to antitubercular therapy in cutaneous tuberculosis; consequently there are no clear guidelines on when to expect a response and also when to abandon a therapeutic trial. "

01/01/1953 - "[Experimental and clinical studies on chemotherapy of cutaneous tuberculosis]."
10/01/2004 - "The diagnosis was tuberculid of the penis and the patient received antituberculosis chemotherapy. "
06/01/2002 - "Biopsy lesions obtained from 17 patients with active cutaneous tuberculosis and 12 patients after a 6-month regimen of antituberculous chemotherapy were examined. "
12/01/1989 - "The case of a young Senegalese man who developed a form of cutaneous tuberculosis associated with a disseminated disease, successfully treated with appropriate antitubercular chemotherapy is reported. "
01/01/1957 - "[Hormonal effects of chemotherapy of cutaneous tuberculosis]."

08/01/2016 - "The development of a device for ultraviolet irradiation of cutaneous tuberculosis by Finnsen at the onset of the twentieth century truly marked the beginning of modern phototherapy. "
01/01/2013 - "Modern phototherapy began with Nobel Prize winner Niels Finsen who developed a "chemical rays" lamp with which he treated patients with skin tuberculosis. "
06/01/2005 - "In 1903, Niels Ryberg Finsen was awarded the Nobel Prize for his invention of light therapy for skin tuberculosis (lupus vulgaris). "

01/01/1945 - "[Treatment of scrofuloderma with injections of lymph]."
05/01/1951 - "Treatment of cutaneous tuberculosis with local injections of streptomycin."
02/01/1951 - "Preliminary and short reports: local injections of streptomycin with intracaine and epinephrine in the treatment of cutaneous tuberculosis; report of three cases."

11/01/1998 - "Papulonecrotic tuberculid - relapse after treatment."
09/01/1990 - "Thirty sera of untreated VL patients, 37 sera 6-90 months after treatment, 18 sera from endemic controls, 8 sera from non-endemic controls and 23 sera from patients with other diseases (schistosomiasis, tuberculosis, cutaneous leishmaniasis) were tested. "
01/01/1955 - "[Peculiarities in the histological picture of cutaneous tuberculosis after treatment with isonicotinic acid hydrazide]."