Tryptophan Synthase (Synthase, Tryptophan)

An enzyme that catalyzes the conversion of L-serine and 1-(indol-3-yl)glycerol 3-phosphate to L-tryptophan and glyceraldehyde 3-phosphate. It is a pyridoxal phosphate protein that also catalyzes the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. (From Enzyme Nomenclature, 1992) EC 4.2.1.20.

Also Known As:

Synthase, Tryptophan; Synthetase, Tryptophan; Tryptophan Synthetase; L-Serine hydro-lyase (adding indoleglycerol-phosphate)

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        Tryptophan Synthase: 11
  - Multienzyme Complexes: 8
    - Tryptophan Synthase: 11

Experts

1.	Belland, Robert J: 2 articles (01/2014 - 06/2003)
2.	Caldwell, Harlan D: 2 articles (07/2005 - 06/2003)
3.	McClarty, Grant: 2 articles (07/2005 - 06/2003)
4.	Roshick, Christine: 2 articles (07/2005 - 06/2003)
5.	Wood, Heidi: 2 articles (07/2005 - 06/2003)
6.	Chang, Changsoo: 1 article (01/2020)
7.	Gusovsky, Fabian: 1 article (01/2020)
8.	Jedrzejczak, Robert: 1 article (01/2020)
9.	Joachimiak, Andrzej: 1 article (01/2020)
10.	Maltseva, Natalia I: 1 article (01/2020)

Related Diseases

1.	Tuberculosis (Tuberculoses) 01/01/2020 - "tuberculosis tryptophan synthase inhibitor. " 01/01/2020 - "tuberculosis tryptophan synthase that belong to sulfolane and indole-5-sulfonamide chemical scaffolds. " 03/01/2019 - "Identification of new benzamide inhibitor against α-subunit of tryptophan synthase from Mycobacterium tuberculosis through structure-based virtual screening, anti-tuberculosis activity and molecular dynamics simulations."
2.	Starvation 07/26/2005 - "Human chlamydial strains, but not the mouse strain, avoid this response by the production of tryptophan synthase that rescues them from tryptophan starvation. " 08/01/1994 - "Conversely, starvation for tryptophan caused a slight elevation of alpha-isopropylmalate synthase and starvation for leucine caused a significant increase of anthranilate synthase and tryptophan synthase specific activities. "
3.	Infections 06/01/2003 - "We previously reported that laboratory reference strains of Chlamydia trachomatis differing in infection organotropism correlated with inactivating mutations in the pathogen's tryptophan synthase (trpBA) genes. " 01/01/2014 - "The latter uniquely encode a functional tryptophan synthase to synthesize tryptophan via indole salvage, should indole be available in the infection microenvironment. "
4.	Dehydration (Water Stress) 01/26/1993 - "Tryptophan synthase also catalyzes the dehydration of serine, or 3-fluoroalanine, to pyruvate in the absence of indole. " 10/01/2023 - "Expression of chorismate mutase regulates phenylalanine biosynthesis, UV light and drought stress-responsive genes, e.g., phenylalanine ammonia lyase (OsPAL), dehydrin (OsDHN), dehydration-responsive element-binding (OsDREB), ras-related protein 7 (OsRab7), ultraviolet-B resistance 8 (OsUVR8), WRKY transcription factor 89 (OsWRKY89) and tryptophan synthase alpha chain (OsTSA). "
5.	Vitamin B 6 Deficiency (Pyridoxine Deficiency) 01/01/1973 - "[Influence of pyridoxine deficiency on tryptophan synthase in Neurospora sitophila]."

Related Drugs and Biologics

1.	Tryptophan (L-Tryptophan)
2.	indole
3.	Pyruvic Acid (Pyruvate)
4.	2-Isopropylmalate Synthase (2 Isopropylmalate Synthase)
5.	Transcription Factors (Transcription Factor)
6.	Serine (L-Serine)
7.	Proteins (Proteins, Gene)
8.	Phenylalanine Ammonia-Lyase
9.	Phenylalanine (L-Phenylalanine)
10.	Leucine (L-Leucine)