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Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)

A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
Also Known As:
Tryptophan 2,3 Dioxygenase; TDO Dioxygenase; Tryptophan 2,3-Dioxygenase; 2,3-Dioxygenase, Tryptophan; Dioxygenase, TDO; Oxygenase, Tryptophan; Pyrrolase, Tryptophan; Tryptophan Pyrrolase; L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Networked: 89 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Weis, Serge: 3 articles (05/2008 - 04/2004)
2. Miller, Christine L: 3 articles (05/2008 - 04/2004)
3. Llenos, Ida C: 3 articles (05/2008 - 04/2004)
4. Guillemin, Gilles J: 2 articles (01/2015 - 01/2013)
5. Vasil'ev, G V: 2 articles (10/2003 - 03/2000)
6. Guastella, Anthony R: 1 article (09/2015)
7. Van den Eynde, Benoît J: 1 article (09/2015)
8. Varadarajan, Kaushik: 1 article (09/2015)
9. Robinette, Natasha L: 1 article (09/2015)
10. Bosnyák, Edit: 1 article (09/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Hepatocellular Carcinoma (Hepatoma)
3. Fatty Liver
4. Porphyrias
5. Hepatic Porphyrias (Hepatic Porphyria)

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Carbon Tetrachloride (Tetrachloromethane)
3. Tryptophan (L-Tryptophan)
4. Tyrosine Transaminase (Tyrosine Aminotransferase)
5. Heme (Haem)
6. Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)
7. Kynurenine
8. Enzymes
9. Serotonin (5 Hydroxytryptamine)
10. Hormones

Related Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Injections
3. Immunotherapy