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Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)

A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
Also Known As:
Tryptophan 2,3 Dioxygenase; TDO Dioxygenase; Tryptophan 2,3-Dioxygenase; 2,3-Dioxygenase, Tryptophan; Dioxygenase, TDO; Oxygenase, Tryptophan; Pyrrolase, Tryptophan; Tryptophan Pyrrolase; L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Networked: 188 relevant articles (3 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Stroobant, Vincent: 5 articles (01/2022 - 08/2011)
2. Yang, Qing: 5 articles (11/2020 - 12/2018)
3. Kuang, Chunxiang: 4 articles (11/2020 - 12/2018)
4. Zhang, Shengnan: 4 articles (11/2020 - 12/2018)
5. Juhász, Csaba: 4 articles (01/2020 - 09/2015)
6. Mittal, Sandeep: 4 articles (01/2020 - 09/2015)
7. Oue, Naohide: 3 articles (06/2022 - 01/2018)
8. Pham, Quoc Thang: 3 articles (06/2022 - 01/2018)
9. Sekino, Yohei: 3 articles (06/2022 - 01/2018)
10. Sentani, Kazuhiro: 3 articles (06/2022 - 01/2018)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Parkinson Disease (Parkinson's Disease)
4. Hepatocellular Carcinoma (Hepatoma)
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)
2. Tryptophan (L-Tryptophan)
3. Immune Checkpoint Inhibitors
4. Enzymes
5. Kynurenine
6. Messenger RNA (mRNA)
7. kynureninase
8. Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)
9. Carbon Tetrachloride (Tetrachloromethane)
10. Heme (Haem)

Related Therapies and Procedures

1. Immunotherapy
2. Therapeutics
3. Transplantation
4. Injections