HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Tryptophan Hydroxylase

An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
Also Known As:
Hydroxylase, Tryptophan; Monooxygenase, Tryptophan; Tryptophan Monooxygenase; L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating)
Networked: 273 relevant articles (3 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bader, Michael: 6 articles (02/2013 - 06/2002)
2. Thomas, Peter: 4 articles (01/2014 - 06/2004)
3. Watanabe, Yuichiro: 4 articles (09/2013 - 11/2007)
4. Someya, Toshiyuki: 4 articles (09/2013 - 11/2007)
5. Walther, Diego J: 4 articles (03/2013 - 06/2002)
6. Lee, Heon-Jeong: 4 articles (05/2012 - 12/2005)
7. Yoon, Ho-Kyoung: 4 articles (05/2012 - 12/2008)
8. Kim, Yong-Ku: 4 articles (08/2010 - 12/2008)
9. Zambrowicz, Brian: 3 articles (09/2015 - 08/2011)
10. Rietschel, Marcella: 3 articles (11/2014 - 01/2008)

Related Diseases

1. Mood Disorders (Mood Disorder)
2. Inflammation
06/01/2014 - "We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal inflammation; moreover, peripheral TPH inhibitors fail to enter the murine enteric nervous system (ENS) or central nervous systems and thus do not affect constitutive gastrointestinal motility. "
03/01/2013 - "Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation."
09/15/2015 - "Intestinal 5-HT synthesis is catalyzed by tryptophan hydroxylase 1 (Tph1) and we have shown that mice deficient in this rate-limiting enzyme have reduced severity of intestinal inflammation in models of chemical-induced experimental colitis. "
03/01/2015 - "Tryptophan hydroxylase 1-knockout mice (TPH1, leading to the absence of 5-HT), TPH1 + 5-hydroxytryptophan (precursor of 5-HT) treatment mice, wild-type (TPH1) mice, and wild-type plus p-chlorophenylalanine (PCPA, TPH1 inhibitor) treatment mice received zymosan intraperitoneally at a dose of 500 mg/kg. Organ failure and systemic inflammation in the mice were assessed 18 h after the administration of zymosan. "
07/01/2010 - "Biopsy specimens were evaluated for inflammation, enterochromaffin cell numbers, 5-HT content, and messenger RNA (mRNA) levels for the synthetic enzyme, tryptophan hydroxylase 1, and the serotonin transporter (SERT) were assessed by quantitative real-time reverse-transcription polymerase chain reaction. "
3. Phenylketonurias (Phenylketonuria)
4. Colitis
5. Schizophrenia (Dementia Praecox)

Related Drugs and Biologics

1. Serotonin (5 Hydroxytryptamine)
2. Neurotransmitter Agents (Neurotransmitter)
3. Lithium
4. Tyrosine (L-Tyrosine)
5. Phenylalanine (L-Phenylalanine)
6. Amino Acids
7. Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)
8. 5-HT1A Serotonin Receptor
9. Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
10. Monoamine Oxidase (MAO)

Related Therapies and Procedures

1. Intraperitoneal Injections
2. Transplants (Transplant)
3. Induced Hyperthermia (Thermotherapy)
4. Drug Therapy (Chemotherapy)