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Tryptophan Hydroxylase

An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
Also Known As:
Hydroxylase, Tryptophan; Monooxygenase, Tryptophan; Tryptophan Monooxygenase; L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating)
Networked: 424 relevant articles (6 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lapuerta, Pablo: 7 articles (11/2019 - 01/2016)
2. Pavel, Marianne: 6 articles (01/2022 - 01/2017)
3. Kulke, Matthew H: 6 articles (01/2019 - 01/2016)
4. Bader, Michael: 6 articles (02/2013 - 06/2002)
5. Hörsch, Dieter: 5 articles (01/2019 - 01/2017)
6. Serretti, Alessandro: 5 articles (09/2015 - 05/2002)
7. Anthony, Lowell B: 4 articles (01/2019 - 01/2017)
8. Bergsland, Emily: 4 articles (01/2019 - 01/2017)
9. Öberg, Kjell: 4 articles (01/2019 - 01/2017)
10. Zambrowicz, Brian: 4 articles (01/2017 - 08/2011)

Related Diseases

1. Carcinoid Tumor (Carcinoid)
2. Mood Disorders (Mood Disorder)
3. Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
4. Inflammation (Inflammations)
06/01/2014 - "We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal inflammation; moreover, peripheral TPH inhibitors fail to enter the murine enteric nervous system (ENS) or central nervous systems and thus do not affect constitutive gastrointestinal motility. "
03/01/2013 - "Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation."
09/15/2015 - "Intestinal 5-HT synthesis is catalyzed by tryptophan hydroxylase 1 (Tph1) and we have shown that mice deficient in this rate-limiting enzyme have reduced severity of intestinal inflammation in models of chemical-induced experimental colitis. "
03/01/2015 - "Tryptophan hydroxylase 1-knockout mice (TPH1, leading to the absence of 5-HT), TPH1 + 5-hydroxytryptophan (precursor of 5-HT) treatment mice, wild-type (TPH1) mice, and wild-type plus p-chlorophenylalanine (PCPA, TPH1 inhibitor) treatment mice received zymosan intraperitoneally at a dose of 500 mg/kg. Organ failure and systemic inflammation in the mice were assessed 18 h after the administration of zymosan. "
07/01/2010 - "Biopsy specimens were evaluated for inflammation, enterochromaffin cell numbers, 5-HT content, and messenger RNA (mRNA) levels for the synthetic enzyme, tryptophan hydroxylase 1, and the serotonin transporter (SERT) were assessed by quantitative real-time reverse-transcription polymerase chain reaction. "
5. Phenylketonurias (Phenylketonuria)

Related Drugs and Biologics

1. Serotonin (5 Hydroxytryptamine)
2. Enzymes
3. telotristat
4. Neurotransmitter Agents (Neurotransmitter)
5. Amino Acids
6. Lithium
7. Tyrosine (L-Tyrosine)
8. Protein Kinases (Protein Kinase)
9. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
10. Phenylalanine (L-Phenylalanine)

Related Therapies and Procedures

1. Therapeutics
2. Intraperitoneal Injections
3. Enzyme Replacement Therapy
4. Radiotherapy
5. Moxibustion