|1.||African Trypanosomiasis (Nagana)
|1.||Magez, Stefan: 9 articles (01/2014 - 02/2004)|
|2.||De Baetselier, Patrick: 9 articles (06/2011 - 02/2004)|
|3.||Stijlemans, Benoît: 8 articles (06/2011 - 02/2004)|
|4.||Brun, Reto: 6 articles (11/2015 - 02/2004)|
|5.||Pépin, Jacques: 5 articles (10/2010 - 09/2002)|
|6.||Kaiser, Marcel: 4 articles (11/2015 - 05/2010)|
|7.||Harada, Shigeharu: 4 articles (07/2014 - 03/2010)|
|8.||Kita, Kiyoshi: 4 articles (07/2014 - 03/2010)|
|9.||Brys, Lea: 4 articles (06/2011 - 09/2007)|
|10.||Vankrunkelsven, Ann: 4 articles (09/2010 - 01/2008)|
|1.||Melarsoprol (Mel B)IBA
08/01/1989 - "Mel-B was also effective against primary and relapse cerebral trypanosomiasis in goats."
08/28/2002 - "The present study compares two methods of preparation of microparticles of melarsoprol for the treatment of the human trypanosomiasis. "
06/01/1997 - "This study enrolled 28 CNS-involved patients with Trypanosoma brucei rhodesiense at the Kenya Trypanosomiasis Research Institute (Alupe, Kenya) to examine treatment efficacy and toxicity of melarsoprol in relation to renal excretion/dose relationships. "
01/01/1992 - "The aim of the study was to assess effects of DFMO (an inhibitor of polyamine biosynthesis) on waking electroencephalogram (EEG) of 25 patients at meningoencephalitic stage of human african gambiense trypanosomiasis (HAT), six of whom having been previously treated with and considered refractory to Melarsoprol. "
08/01/1991 - "The purpose of the study was to assess the long-term effects of melarsoprol on awakening electroencephalogram (EEG) in 18 patients at the meningo-encephalic stage of human African gambiense trypanosomiasis. "
|2.||Suramin (Suramin Sodium)IBA
08/01/1989 - "Six of nine goats with cerebral trypanosomiasis induced by this stock were cured by a single high dose of suramin (50 mg kg-1). "
12/01/2014 - "Suramin has been used previously to treat trypanosomiasis in Africa. "
05/01/2011 - "Suramin is a polysulfonated naphthylurea, which was originally synthesized and designed as a treatment for trypanosomiasis and selected malignancies and metastatic diseases. "
10/01/2006 - "The first reported human case of trypanosomiasis caused by Trypanosoma evansi was treated using suramin. "
05/01/1994 - "Suramin is a polysulfonated naphthylurea developed originally to treat trypanosomiasis. "
|3.||Eflornithine (Ornidyl)FDA Link
01/01/2000 - "The 7-day course of eflornithine is an effective treatment of relapsing cases of Gambian trypanosomiasis. "
02/01/1988 - "Eflornithine was a safe and effective agent for treatment of trypanosomiasis with central nervous system involvement in this child."
04/01/1989 - "In a multiclinic trial in Brazzaville, Congo, 14 patients with late-stage Trypanosoma brucei gambiense trypanosomiasis were treated with eflornithine. "
04/01/1989 - "[A trial treatment with eflornithine of trypanosomiasis caused by Trypanosoma brucei gambiense in the Peoples Republic of the Congo]."
10/01/2006 - "Eflornithine seems to be a better first-line therapy for treating late-stage Gambian trypanosomiasis in the Republic of the Congo."
02/01/1995 - "Partial protection against natural trypanosomiasis after vaccination with a flagellar pocket antigen from Trypanosoma brucei rhodesiense."
04/01/1998 - "The antigen detection enzyme immunoassay (AgELISA) in conjunction with parasitological examination of blood were used to study the enzootic situation of cameline trypanosomiasis in mid-Eastern Sudan. "
12/01/2008 - "The usefulness of antigen capture ELISA in the diagnosis of human or animal trypanosomiasis was established, and the possibility of the spread of HAT caused by T. "
09/01/1997 - "A simple and rapid test, the card indirect agglutination trypanosomiasis test (TrypTect CIATT) is described, for detecting circulating antigens in persons suffering from Trypanosoma brucei gambiense and T. "
05/01/1996 - "The LiTat 1.3 and AnTat 11.17 genes are considered to be characteristic of G stocks, and neither gene was found in the non-G stocks; however, the LiTat 1.3 gene was absent from 6 of the 58 G stocks, while the AnTat 11.17 gene was absent from 8. Supplementation of the LiTat 1.3 antigen in the Card Agglutination Test for Trypanosomiasis with the AnTat 11.17 antigen might thus improve performance of the test, particularly in Cameroon. "
|5.||Pentamidine (NebuPent)FDA LinkGeneric
12/01/1996 - "The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis."
01/01/1988 - "[Trial of pentamidine in the treatment of trypanosomiasis of sheep inoculated with Trypanosoma brucei brucei]."
08/13/2009 - "An oral prodrug of diamidine 6, diamidoxime 9, administered at 25 mg/kg daily for 4 days, exhibited excellent antitrypanosomal efficacy in vivo curing all infected animals in the STIB900 acute mouse model of trypanosomiasis."
12/01/1996 - "Fifty-eight patients in the early-late stage (early central nervous system involvement) of Trypanosoma brucei gambiense trypanosomiasis were treated with pentamidine and divided into four groups (G1, G2, G3, and G4) according to cerebrospinal fluid (CSF) indicators: white blood cell (WBC) count, protein level (CSF protein), and the presence or absence of trypanosomes. "
12/01/1995 - "The results of the in vivo tests confirmed the ability of the in vitro screen to predict drug efficacy, and also suggests that better analogues of pentamidine (less host toxicity and greater trypanocidal activity) can be obtained to treat human trypanosomiasis."
01/01/1992 - "DFMO is not very active in rhodesiense sleeping sickness and experience with nifurtimox in this form of trypanosomiasis is too limited to draw valid conclusions. "
10/01/1998 - "In the search for novel antitoxoplasmic agents, we evaluated the efficacy of nifurtimox (3-methyl-4[5'-nitrofurfurylidene-amino]-tetrahydroe-4H-1,4- thiazine-1,1-dioxide), an antiprotozoal drug effective against trypanosomiasis, in an experimental model of acute toxoplasmosis in mice. "
02/01/2007 - "We here discuss the use of current drugs against human and veterinary African trypanosomiasis, the prevalence, causes and mechanisms of drug resistance and new developments in trypanosomiasis therapy such as the introduction of nifurtimox and DB289."
11/01/2015 - "Nifurtimox is a 5-nitrofuran derived antiprotozoal drug used to treat diseases caused by trypanosomes including Chagas' disease and sleeping sickness (African trypanosomiasis). "
02/01/2014 - "A significant improvement in the treatment of trypanosomiases has been achieved with the recent development of nifurtimox-eflornithine combination therapy (NECT). "
08/01/2010 - "The results of the Benznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT) trial in 2012 will also help to inform treatment. "
10/01/2014 - "cruzi, and developed cerebral trypanosomiasis that was successfully treated with benznidazole at 7 mg/kg/day for 60 days. "
01/01/2013 - "The Benznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) study is an international, multicenter, randomized, double-blinded and placebo-controlled clinical trial to evaluate the efficacy of benznidazole (BZ) treatment in patients with chronic Chagas cardiomyopathy (CCC). "
07/01/2009 - "The BENEFIT project--Benznidazole Evaluation for Interrupting Trypanosomiasis--is an international, multicenter, double-blind, placebo-controlled trial of trypanocidal treatment with benznidazole in patients with chronic Chagas heart disease. "
07/01/2008 - "Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)."
01/01/1970 - "[Studies on the specific antibodies during trypanosomiasis due to T. "
10/18/2013 - "In the context of the Pan African Tsetse and Trypanosomiasis Eradication Campaign, the value of tsetse saliva antibodies as a biomarker of cattle exposure to tsetse flies was evaluated, as this could provide an alternative and complementary tool to conventional entomological methods. "
01/01/2010 - "Trypanosome-specific antibodies are detectable in blood by the Card Agglutination Test for Trypanosomiasis (CATT). "
11/01/1994 - "Agglutinating antibodies were detected by the T.evansi card agglutination test for trypanosomiasis (CATT/T.evansi) in 14.6%, 1.3%, 15.7% and 22.0% of the horses, cattle, dogs and capybaras, respectively. "
05/01/1992 - "Maternal antibodies in N'Dama calves kept under natural trypanosomiasis risk in The Gambia."
02/01/1984 - "During the 21-month study trypanosomiasis was the most frequently encountered disease in the cattle in the Berenil treatment group with an average of 5.5 reinfections. "
09/01/1983 - "Studies carried out on feedlot cattle show Berenil at 7 mg/kg to be the treatment of choice in trypanosomiasis although repeated doses may be necessary. "
08/01/2014 - "Diminazene aceturate or Berenil has been the drug of choice for treatment of animal trypanosomiasis. "
01/01/2012 - "Homidium chloride and diminazene aceturate are registered drugs for the treatment of animal trypanosomiasis. "
01/01/2012 - "Diminazene aceturate (Berenil) has been widely used as a chemotherapeutic agent for trypanosomiasis in livestock since 1955. "
10/15/1980 - "I. A study of trypanosomiasis occurrence and the use of trypanocidal agents]."
01/01/2012 - "Modeling the control of trypanosomiasis using trypanocides or insecticide-treated livestock."
02/18/2006 - "In large parts of Africa the control of livestock trypanosomiasis relies on the use of trypanocidal drugs. "
04/01/2003 - "One third of drug treatments given to sick cattle were trypanocides, but over half of these trypanocidal treatments were given to cattle believed to have diseases other than trypanosomiasis."
03/01/2002 - "When presented with four different trypanosomiasis control methods, community representatives selected 'better use of trypanocides' as the most preferred intervention and 'community-based tsetse control' as the least preferred intervention. "
|1.||Drug Therapy (Chemotherapy)
06/01/1994 - "High parasitaemia, anaemia and clinical symptoms of human trypanosomiasis were found in the infected patients and were eliminated with chemotherapy in the infected/treated patients. "
01/01/2015 - "Vector control and chemotherapy are the contemporary methods of tsetse and trypanosomiasis control in this region. "
01/01/2014 - "Current chemotherapies against trypanosomiasis are beset with diverse challenges, a situation which underscores the numerous research efforts aimed at finding newer and effective treatments. "
01/01/2013 - "Metacaspases, autophagins and metallocarboxypeptidases: potential new targets for chemotherapy of the trypanosomiases."
01/01/2013 - "They act through multiple mechanisms in the chemotherapy of trypanosomiasis. "
|2.||Traditional Medicine (Folk Remedies)
10/01/1989 - "brucei in mice, which agrees with the claims of Nigerian practitioners of Traditional Medicine that it is effective against trypanosomiasis in man."
05/01/2012 - "ukambensis showed significant activity with an inhibitory concentration (IC(50)) of 6.9 μg/ml. The results of this study contribute to the promotion of traditional medicine products and are preliminary for the isolation of new natural molecules for the treatment of leishmaniasis and trypanosomiasis."
05/04/2010 - "(Asteraceae), a plant commonly used in folk medicine for a number of illnesses including sleeping sickness, was recently found to exhibit a prominent activity (IC(50)=0.78 microg/mL) against bloodstream forms of Trypanosoma brucei rhodesiense, the etiologic agent of East African Human Trypanosomiasis (East African Sleeping Sickness). "
01/01/2013 - "The residents in Kenya (6.7%) applied chemoprophylaxis and chemotherapeutic controls against trypanosomiasis to a larger extent than Uganda (2.1%). "
01/01/1990 - "A programme of chemoprophylaxis against trypanosomiasis has been work out for the protection of newly imported N'Dama cattle from the Gambia, the Senegal and Zaire into Gabon. "
01/01/1953 - "[Chemoprophylaxis of human trypanosomiasis in French West Africa from 1947 to 1953]."
09/01/1951 - "[Additional note on the subject of chemoprophylaxis of human trypanosomiasis in French Equatorial Africa]."
01/01/1951 - "[Results obtained in French Equatorial Africa by the use of diamidines in the chemoprophylaxis of human trypanosomiasis from 1946 to 1949]."
03/01/1997 - "Four patients died after treatment, 2 of them possibly due to trypanosomiasis. "
06/01/1993 - "The ELISA was shown to detect serum ISMM for several months after treatment of cattle in a trypanosomiasis endemic country. "
08/01/1992 - "Among the three HIV-1 seropositive incident cases of trypanosomiasis treated with difluoromethylornithine, two (67%) relapsed after treatment compared with four of 39 (10%) HIV-1 seronegative incident cases treated with the same drug (P = 0.05). "
07/25/1992 - "Persistence of antibodies to Trypanosoma brucei gambiense after treatment of human trypanosomiasis in Uganda."
03/01/1997 - "A 7 d course of intravenous eflornithine is an adequate treatment for cases of Gambian trypanosomiasis relapsing after treatment with another drug."