Tropomyosin

A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.

Also Known As:

Miniparamyosin; Paratropomyosin; Tropomyosin Mg; alpha-Tropomyosin; beta-Tropomyosin; gamma-Tropomyosin; Mg, Tropomyosin; alpha Tropomyosin; beta Tropomyosin; gamma Tropomyosin; Paramyosin

Networked: 1380 relevant articles (46 outcomes, 136 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Redwood, Charles S: 22 articles (06/2021 - 12/2003)
2.	Borovikov, Yurii S: 18 articles (06/2021 - 04/2009)
3.	Karpicheva, Olga E: 18 articles (06/2021 - 04/2009)
4.	Wieczorek, David F: 17 articles (01/2019 - 09/2003)
5.	Gunning, Peter W: 15 articles (01/2022 - 08/2004)
6.	Solaro, R John: 14 articles (01/2021 - 10/2003)
7.	Hardeman, Edna C: 12 articles (01/2022 - 08/2004)
8.	Avrova, Stanislava V: 12 articles (06/2021 - 09/2009)
9.	Lehman, William: 12 articles (12/2020 - 01/2010)
10.	Wolska, Beata M: 11 articles (01/2021 - 07/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "A phase 1b open-label safety study, followed by a phase 2a within-patient randomized (by tumor), double-blind, placebo-controlled trial (the Tropomyosin Receptor Antagonism in Cylindromatosis [TRAC] trial). " 01/01/2017 - "Our data suggest that small molecules targeting the actin cytoskeleton via tropomyosin sensitize cancer cells to antimicrotubule agents and are tolerated together in vivo This combination warrants further study. " 05/11/2007 - "In this study, we performed two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target. " 06/01/1997 - "The thyroid TRK oncogenes are activated by recombination with at least three different genes: the gene coding for tropomyosin and TPR, both on chromosome 1,and TFG on chromosome 3. In a previous study, we showed that two tumors carrying the TPR/NTRK1 rearrangement contained structurally different oncogenes named TRK-T1 and TRK-T2. " 08/27/2023 - "Research Advances in the Role of the Tropomyosin Family in Cancer."
2.	Hypersensitivity (Allergy) 10/01/2023 - "The study results highlighted that allergic reactions to Imbrasia belina reported in Gwanda district are associated with the presence of the tropomyosin gene, which has undergone polymorphism. " 12/15/2021 - "Reducing the Allergenicity of Shrimp Tropomyosin and Allergy Desensitization Based on Glycation Modification." 01/01/2021 - "Tropomyosin only accounted for 53.3% of sensitization among subjects with challenge-proven shrimp allergy. " 03/15/2019 - "Conformation, allergenicity and human cell allergy sensitization of tropomyosin from Exopalaemon modestus: Effects of deglycosylation and Maillard reaction." 01/01/2019 - "The extensive cross-reactivity between tropomyosin of house-dust mite and crustacean shellfish has been postulated to be the cause of a proposed mite-shellfish oral allergy syndrome. "
3.	Infections 03/01/1993 - "Prior studies have shown that such immunization stimulates a much stronger antibody response to recombinant and native filarial paramyosin than that seen after normal infection. " 02/01/2020 - "Immunodiagnostic potential of recombinant tropomyosin during prepatent Haemonchus contortus infection in goat." 02/01/2020 - "Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection." 01/01/2016 - "lupi paramyosin, for the diagnosis of this infection, in order to gain more information on the real distribution of this little known filarioid of zoonotic concern." 06/01/2006 - "Localized accumulation of tropomyosin at the infection sites may facilitate parasite invasion."
4.	Cognitive Dysfunction 05/01/2016 - "Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist." 01/01/2015 - "The aim of the present study was to determine whether or not calorie restriction results in protection against cognitive decline via BDNF and its receptor tropomyosin-related kinase B (TrkB) in the hippocampus of MetS model rats. " 01/01/2015 - "Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus ofobesity-induced hypertensive rats." 01/01/2020 - "Yizhi Qingxin Formula Extract Ameliorates Cognitive Decline in Aged Rats via the Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Pathway." 04/01/2019 - "Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway."
5.	Pain (Aches) 01/01/2020 - "The tropomyosin receptor kinase (TRK) pathway controls appetite, balance, and pain sensitivity. " 07/31/2006 - "Full-length tropomyosin-related kinase B expression in the brainstem in response to persistent inflammatory pain." 01/09/2014 - "Inhibitors of Tropomyosin-Receptor Kinases (Trk's): Potential Pain Therapy and More." 06/14/2012 - "Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. " 01/01/2016 - "Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	larotrectinib
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Proteins (Proteins, Gene)
5.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
6.	entrectinib
7.	Antibodies
8.	Peptides (Polypeptides)
9.	Immunoglobulin E (IgE)
10.	Vaccines

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Oral Administration
4.	Vertical Dimension (Occlusion Vertical Dimension)
5.	Intra-Articular Injections