Tropoelastin

01/01/2017 - "This study demonstrates that tropoelastin seeding is beneficial in preventing SMC proliferation and neointimal hyperplasia in bioresorbable arterial vascular grafts. "
01/01/2017 - "In this study, we investigated the efficacy of tropoelastin seeding in preventing neointimal hyperplasia of bioresorbable arterial vascular grafts. "
01/01/2017 - "Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts."
08/08/2016 - "2TE, but not 1TE, enhanced the vascular compatibility of these materials: while both tropoelastin presentations increased in vitro endothelialization, only 2TE displayed the dual benefits of maintained hemocompatibility and simultaneously suppressed neointimal hyperplasia in vivo. "
01/01/2011 - "Because of the unique effects of tropoelastin on endothelial and smooth muscle cells, coating intravascular devices with tropoelastin may stimulate their endothelialization, inhibit smooth muscle hyperplasia, and improve device performance."

01/01/2018 - "The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. "
01/01/2018 - "Tropoelastin Implants That Accelerate Wound Repair."
03/11/2015 - "It is concluded that including tropoelastin in a dermal regeneration template has the potential to promote wound repair through enhanced vascularization. "
03/11/2015 - "Tropoelastin incorporation into a dermal regeneration template promotes wound angiogenesis."
05/01/2014 - "Objective: To evaluate the physiological effects of electrospun tropoelastin scaffolds as therapeutic adipose-derived stem cell (ADSC) delivery vehicles for the treatment of full-thickness dermal wounds. "

01/01/2018 - "Imaging Tropoelastin in Atherosclerosis."
12/01/2000 - "Tropoelastin is closely associated with foam cell lesion formation, suggesting a role for this component in atherogenesis as well."
10/28/2021 - "Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin."
12/01/2000 - "We studied the mural distribution of collagen types I and III and tropoelastin in enhanced experimental atherogenesis induced in rabbits by hyperlipidemia superimposed by hypertension. "

03/01/1979 - "When bound to alpha2-M, the enzyme retained approximately 6 per cent of its activity toward tropoelastin and solubilized latter observations suggest that alpha2-M--bound elastase, cleared slowly from lung extracellular tissue space, may participate normally in the turnover of soluble precursor (s) of elastin and may contribute to the development of emphysema in alpha1-antitrypsin deficiency."

01/01/1999 - "Taken together, these data indicate that hypoxia regulates tropoelastin gene expression and may alter repair of acutely injured lung."
01/01/1999 - "Hypoxia induced early decreases in tropoelastin mRNA stability; minor suppression of gene transcription occurred later. "
01/01/1999 - "Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms."
11/01/1991 - "In order to determine the direct effects of hypoxia on tropoelastin production by pulmonary artery SMC, cultured neonatal bovine pulmonary artery SMC were exposed to 3%, 10%, and 21% O2 concentrations for 48, 72, and 120 h and soluble tropoelastin was measured by direct immunoassay. "
11/01/1991 - "The primary stimulus for the increased tropoelastin production, which persists in vitro, is unknown but mechanical forces and hypoxia seem to play a role. "