Tritolyl Phosphates (Tricresyl Phosphate)

A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.

Also Known As:

Tricresyl Phosphate; Tritolyl Phosphate; Phosphate, Tricresyl; Phosphate, Tritolyl; Phosphates, Tricresyl; Phosphates, Tritolyl; Tricresyl Phosphates

Networked: 32 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Cresols: 9
        Tritolyl Phosphates: 32
        tri-o-cresyl phosphate: 117
        triparacresyl phosphate: 1
        IMOL S-140
- Organophosphorus Compounds: 300
  - Organophosphates: 1942
    - Tritolyl Phosphates: 32

Experts

1.	Bajard, Lola: 1 article (11/2021)
2.	Blaha, Ludek: 1 article (11/2021)
3.	Kohoutek, Jiri: 1 article (11/2021)
4.	Negi, Chander K: 1 article (11/2021)
5.	Darwish, Hany W: 1 article (06/2021)
6.	Darwish, Ibrahim A: 1 article (06/2021)
7.	Draz, Mohammed E: 1 article (06/2021)
8.	Saad, Ahmed S: 1 article (06/2021)
9.	Chang, Yeqian: 1 article (12/2020)
10.	Cui, Haiyan: 1 article (12/2020)

Related Diseases

1.	Neuritis (Polyneuritis) 09/01/1964 - "[ELECTROLOGIC STUDY OF POLYNEURITIS CAUSED BY TRICRESYL PHOSPHATES. " 10/01/1960 - "[Tricresyl phosphate-induced myelo-polyneuritis. " 03/01/1960 - "Outbreak of polyneuritis in Bombay with a syndrome clinically indistinguishable from tricresyl phosphate poisoning and with demonstration of tricresyl phosphate in a sample of mustard oil."
2.	Pheochromocytoma 12/01/2020 - "This study investigated the neurotoxicity of alkyl tri-n-butyl phosphate (TnBP) and aromatic tricresyl phosphate (TCP) to rat adrenal pheochromocytoma (PC12) cells for 24 h. " 01/01/1994 - "The effects of three representative organophosphates (OPs), tricresyl phosphate (TCP), triphenyl phosphite (TPP) and paraoxon (POX) on the proliferation and viability of rat PC12 pheochromocytoma cells were studied. "
3.	Carcinogenesis 09/01/1994 - "NTP Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CAS No. 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)." 09/01/1994 - "Toxicology and carcinogenesis studies were conducted by administering a mixed isomer preparation of 79% tricresyl phosphate esters (consisting of 21% tri- m-cresyl phosphate, 4% tri- p-cresyl phosphate, less than 1% tri- o-cresyl phosphate, and other unidentified tricresyl phosphate esters) by gavage to groups of F344/N rats and B6C3F1 mice for 16 days and 13 weeks, and in feed to groups of F344/N rats and B6C3F1 mice for 13 weeks and 2 years. "
4.	Obesity 01/01/2020 - "In this study, adult male and female mice (C57BL/6J; Taconic) were treated with the same mixture of OPFRs (1 mg/kg each of tricresyl phosphate (TCP), triphenyl phosphate (TPP), and tris(1-3-dichloro-2propyl)phosphate (TDCPP)) for 7 weeks on a low-fat diet (LFD, 10% kcal fat) or a high fat (HFD, 45% kcal fat) in a diet-induced obesity model. "
5.	Hyperplasia 09/01/1994 - "Dose selection for the 2-year study in rats was based on lower mean body weights; toxic responses observed in the kidney, pituitary gland, and testis of males and the kidney of females exposed to 6,600 and 13,000 ppm; the presence of cytoplasmic vacuolization of the adrenal cortex in exposed males and females; and the occurrence of ovarian interstitial cell hyperplasia in females exposed to 900 and 1,700 ppm. 13-WEEK FEED STUDY IN MICE: Groups of 10 male and 10 female mice were fed diets containing 0, 250, 500, 1,000, 2,100, or 4,200 ppm of tricresyl phosphate. " 09/01/1994 - "CONCLUSIONS: Under the conditions of these 2-year feed studies, there was no evidence of carcinogenic activity of tricresyl phosphate in male or female F344/N rats that received 75, 150, or 300 ppm. There was no evidence of carcinogenic activity of tricresyl phosphate in male or female B6C3F1 mice that received 60, 125, or 250 ppm. Nonneoplastic lesions associated with exposure to tricresyl phosphate included cytoplasmic vacuolization of the adrenal cortex and ovarian interstitial cell hyperplasia in female rats, increased incidences of clear cell focus, fatty change, and ceroid pigmentation of the liver in male mice, and increased severity of ceroid pigmentation of the adrenal cortex in female mice."

Related Drugs and Biologics

1.	Phosphates (Orthophosphate)
2.	triphenyl phosphate
3.	tri-o-cresyl phosphate (TOCP)
4.	Esters
5.	Corn Oil (Oil, Corn)
6.	Ceroid
7.	tributyl phosphate (TBP)
8.	Cholinesterases (Cholinesterase)
9.	Nerve Growth Factor (NGF)
10.	Vinyl Chloride (Chloroethylene)

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)