Trimethadione (Tridione)

01/01/1992 - "All of these models share behavioral and EEG similarity to human absence seizures and show pharmacologic specificity for antiabsence drugs such as ethosuximide and trimethadione. "
09/01/1988 - "the absence-like seizures were inhibited by trimethadione (100 mg/kg intraperitoneally, i.p.) and ethosuximide 100 mg/kg i.p.), whereas the tonic convulsion was not affected by these drugs. "
11/01/1986 - "Of those drugs used exclusively for treatment of absence seizures, trimethadione (12.5-800 mg/kg) caused dose-related inhibitions to 37.6 +/- 9.8% of base-line, whereas ethosuximide (12.5-800 mg/kg) markedly stimulated firing, nearly doubling firing rates after the 200 mg/kg dose.(ABSTRACT TRUNCATED AT 250 WORDS)"
02/01/1978 - "L-5418 and dephenylhydantoin did not increase the threshold of seizures induced by bemegride while trimethadione raised the threshold. "
03/01/1977 - "Trimethadione, acetazolamide, and dipropylacetate facilitated the focal seizure. "

01/01/1946 - "TRIDIONE: a modern drug effective in forms of epilepsy resistant to ordinary medication."
01/01/1977 - "[Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy]."
07/28/1955 - "Use of the dione drugs (propazone, tridione, paradione, dimedione and malidone) in the treatment of epilepsy of children."
04/01/1951 - "Fifty cases of epilepsy treated with "tridione"."
08/06/1949 - "Tridione in the treatment of epilepsy."

02/01/1963 - "Trimethadione nephrosis."
02/01/1952 - "[Tridione and nephrosis]."
02/05/1949 - "Nephrosis occurring during trimethadione therapy; report of a case."
01/01/1953 - "Attempts to produce experimental lipid nephrosis with tridione."
08/01/1967 - "Successful therapy of trimethadione nephrosis with prednisone and cyclophosphamide. "

03/01/1992 - "We examined the possibility of predicting the extent of hepatic drug-oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. "
03/01/1992 - "In rats with liver injuries, total body clearance of caffeine and trimethadione showed a strong correlations (r = 0.99, P less than 0.01); also total body clearance of caffeine correlated well with the ratio of dimethadione/trimethadione after 1, 2, and 4 hr of trimethadione administration (r = 0.93, P less than 0.01; r = 0.97, P less than 0.01 and r = 0.97, P less than 0.01 respectively). "
08/14/1953 - "[Bone marrow injuries by modern anticonvulsants: hydantoins and tridione]."
03/01/1992 - "In rats with chemically induced liver injuries pretreated with carbon tetrachloride (CCl4: 0.25 ml/kg), alpha-naphthylisothiocyanate (ANIT: 40 mg/kg), or D-galactosamine (GalN: 400 mg/kg), the half-life (t1/2) of caffeine and trimethadione was significantly (P less than 0.01) prolonged compared to those of control groups total body clearance as dramatically reduced (P less than 0.01), whereas apparent volumes of distribution (Vds) were increased in ANIT and GalN groups. "

10/01/2015 - "We report a case of pancreatolithiasis in which glucose intolerance and malnutrition were significantly improved after starting oral litholysis therapy (OLT) with use of trimethadione. "