|1.||Ozolinš, Terence R S: 2 articles (11/2015 - 12/2014)|
|2.||Purssell, Elizabeth: 2 articles (12/2014 - 12/2014)|
|3.||Tanaka, E: 2 articles (12/2001 - 06/2000)|
|4.||Brown, Nigel A: 1 article (11/2015)|
|5.||Weston, Andrea D: 1 article (11/2015)|
|6.||Thomson, Jason J: 1 article (11/2015)|
|7.||Perretta, Anthony: 1 article (11/2015)|
|8.||Noda, Aiji: 1 article (10/2015)|
|9.||Ashizawa, Nobuo: 1 article (10/2015)|
|10.||Hamano, Koichi: 1 article (10/2015)|
01/01/1972 - "1. The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken.2. AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species.3. The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks.4. The convulsant effect was exerted primarily through supraspinal centres.5. Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures."
01/01/1984 - "However, trimethadione had anticonvulsant activity indicating that this model is only relatively specific for the above seizure types. "
02/01/1978 - "Trimethadione produced an inhibitory effect on both tonic and clonic convulsions. "
10/01/1952 - "Near fatal hemolytic anemia during anti-epileptiform convulsion therapy with tridione."
08/01/2014 - "A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice."
|2.||Absence Epilepsy (Absence Seizure)
05/01/1965 - "A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY."
08/01/1990 - "Trimethadione which has been used for the petit mal epilepsy should not be used because of the high potent of teratogenicity. "
06/01/1962 - "Trimethadione in serum of patients with petit mal epilepsy."
01/01/1951 - "The treatment of petit mal epilepsy with tridione; report of 21 cases."
05/01/1950 - "[Tridione therapy of petit mal epilepsy]."
01/01/1946 - "TRIDIONE: a modern drug effective in forms of epilepsy resistant to ordinary medication."
01/01/1977 - "[Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy]."
07/28/1955 - "Use of the dione drugs (propazone, tridione, paradione, dimedione and malidone) in the treatment of epilepsy of children."
04/17/1953 - "[Complications of tridione therapy of epilepsy in children]."
08/20/1952 - "[Tridione in therapy of epilepsy]."
02/01/1963 - "Trimethadione nephrosis."
01/01/1953 - "Attempts to produce experimental lipid nephrosis with tridione."
02/01/1952 - "[Tridione and nephrosis]."
02/05/1949 - "Nephrosis occurring during trimethadione therapy; report of a case."
08/01/1967 - "Successful therapy of trimethadione nephrosis with prednisone and cyclophosphamide. "
|5.||Wounds and Injuries (Trauma)
03/01/1992 - "We examined the possibility of predicting the extent of hepatic drug-oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. "
03/01/1992 - "In rats with liver injuries, total body clearance of caffeine and trimethadione showed a strong correlations (r = 0.99, P less than 0.01); also total body clearance of caffeine correlated well with the ratio of dimethadione/trimethadione after 1, 2, and 4 hr of trimethadione administration (r = 0.93, P less than 0.01; r = 0.97, P less than 0.01 and r = 0.97, P less than 0.01 respectively). "
08/14/1953 - "[Bone marrow injuries by modern anticonvulsants: hydantoins and tridione]."
03/01/1992 - "In rats with chemically induced liver injuries pretreated with carbon tetrachloride (CCl4: 0.25 ml/kg), alpha-naphthylisothiocyanate (ANIT: 40 mg/kg), or D-galactosamine (GalN: 400 mg/kg), the half-life (t1/2) of caffeine and trimethadione was significantly (P less than 0.01) prolonged compared to those of control groups total body clearance as dramatically reduced (P less than 0.01), whereas apparent volumes of distribution (Vds) were increased in ANIT and GalN groups. "
|1.||Anticonvulsants (Antiepileptic Drugs)
|5.||Valproic Acid (Valproate, Semisodium)
|2.||Lithotripsy (Extracorporeal Shockwave Lithotripsy)
|4.||Diet Therapy (Therapy, Diet)