|3.||Neuralgia (Stump Neuralgia)
|5.||Migraine Disorders (Migraine)
|1.||Li, Shi-Ting: 13 articles (11/2015 - 11/2004)|
|2.||Zakrzewska, Joanna M: 13 articles (01/2013 - 02/2002)|
|3.||Zhong, Jun: 11 articles (10/2014 - 09/2008)|
|4.||Burchiel, Kim J: 10 articles (01/2011 - 01/2002)|
|5.||Zhu, Jin: 8 articles (10/2014 - 04/2011)|
|6.||Sindou, Marc: 7 articles (07/2011 - 12/2007)|
|7.||Matsushima, Toshio: 6 articles (04/2015 - 04/2003)|
|8.||Bae, Yong C: 6 articles (08/2012 - 07/2009)|
|9.||Ahn, Dong K: 6 articles (08/2012 - 07/2009)|
|10.||Broggi, Giovanni: 6 articles (06/2012 - 01/2004)|
|1.||Carbamazepine (Tegretol)FDA LinkGeneric
02/01/2015 - "Carbamazepine was found to be highly effective in trigeminal neuralgia. "
01/01/1985 - "Carbamazepine is considered the drug of choice and is initially very effective in treating trigeminal neuralgia. "
12/01/2014 - "Carbamazepine (CBZ) formed the gold standard drug in trigeminal neuralgia (TN) treatment but faces high therapeutic failure. "
01/01/1985 - "Trigeminal neuralgia was diagnosed, and carbamazepine therapy was initiated with good results. "
01/01/1997 - "Is carbamazepine less effective in the treatment of trigeminal neuralgia when prescribed by oral and maxillofacial surgeons?"
|2.||Anticonvulsants (Antiepileptic Drugs)IBA
01/01/2007 - "Anticonvulsants are effective in treating trigeminal neuralgia; however, few studies with high levels of evidence were found. "
09/01/2010 - "Antiepileptic drugs (AEDs) are considered as first-line treatment for trigeminal neuralgia, although their use is often limited due to incomplete efficacy and tolerability. "
01/01/2006 - "The objective was to review systematically the efficacy of non-antiepileptic drugs for trigeminal neuralgia. "
01/01/2013 - "There is insufficient evidence from randomised controlled trials to show significant benefit from non-antiepileptic drugs in trigeminal neuralgia. "
01/01/2011 - "There is insufficient evidence from randomized controlled trials to show significant benefit from non-antiepileptic drugs in trigeminal neuralgia. "
12/01/1991 - "Oral baclofen, the most often prescribed antispastic drug, has been shown to be effective in trigeminal neuralgia. "
11/01/1987 - "Our results suggest that L-baclofen represents a significant improvement over racemic baclofen in the treatment of trigeminal neuralgia, and support our laboratory observations indicating that D-baclofen antagonizes the action of L-baclofen."
12/01/1980 - "Our results suggest that baclofen may be a useful drug in the treatment of trigeminal neuralgia and that our experimental model may successfully predict the efficacy of a drug in the treatment of this condition."
05/01/1985 - "Drugs that depress afferent excitation and facilitate segmental inhibition but do not depress the reticular system (baclofen) are effective against trigeminal neuralgia but do not have clinical antiepileptic properties. "
01/01/1984 - "These results substantiate that baclofen is useful in the treatment of trigeminal neuralgia and other painful conditions."
|4.||lamotrigine (Lamictal)FDA LinkGeneric
06/13/2000 - "There have been anecdotal reports of efficacy of lamotrigine in the treatment of painful neuropathy and trigeminal neuralgia. "
11/01/1997 - "Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial."
08/01/1997 - "Lamotrigine control of trigeminal neuralgia: an expanded study."
06/01/1997 - "Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia."
12/01/1995 - "Lamotrigine control of idiopathic trigeminal neuralgia."
|5.||Glycerol (Glycerine)FDA LinkGeneric
03/01/2015 - "The objective of this study was to determine the long-term efficacy of percutaneous glycerol rhizolysis of the trigeminal ganglion for treating patients with trigeminal neuralgia and search for predictors associated with (long-term) benefit to improve patient selection. "
03/01/2015 - "The present study demonstrates that involvement of the third branch is a negative predictor for long-term outcome in percutaneous glycerol rhizolysis of the trigeminal ganglion in patients with classical trigeminal neuralgia. "
02/01/1995 - "The aim of the present study was to evaluate the influence of previous treatment on outcome and sensory disturbance after a retrogasserian glycerol injection for trigeminal neuralgia. "
01/23/1994 - "The authors of the present study report on their results with glycerol gained over the past 9 years in 142 cases of trigeminal neuralgia. "
03/01/2015 - "A retrospective study in 60 consecutive patients treated with percutaneous glycerol rhizolysis of the trigeminal ganglion for trigeminal neuralgia. "
|6.||gabapentin (Neurontin)FDA LinkGeneric
11/01/2001 - "In the treatment of trigeminal neuralgia, gabapentin has been shown to be effective in an open-label study. "
04/01/2002 - "The present study suggests that gabapentin can be effective as first or second line treatment of trigeminal neuralgia, even in cases resistant to traditional treatment modalities."
02/01/2008 - "Gabapentin for refractory idiopathic trigeminal neuralgia."
04/01/2002 - "Defining the role for gabapentin in the treatment of trigeminal neuralgia: a retrospective study."
08/01/1998 - "Gabapentin may be a valuable addition to pharmacologic therapy in trigeminal neuralgia, particularly in patients with MS and in refractory cases."
|7.||Phenytoin (Dilantin)FDA LinkGeneric
05/01/1958 - "[Fifteen years of trial therapy of essential trigeminal neuralgia: the place of diphenylhydantoin and its derivatives]."
01/01/2012 - "Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigeminal neuralgia. "
11/01/2011 - "The case of a patient who was successfully treated with i.v. phenytoin for an acute exacerbation of refractory trigeminal neuralgia (TN) is reported. "
11/01/2011 - "Treatment of refractory trigeminal neuralgia with intravenous phenytoin."
12/01/2003 - "The case of a nonepileptic patient who developed psychosis following phenytoin treatment for trigeminal neuralgia is described. "
|8.||oxcarbazepine (Trileptal)FDA LinkGeneric
04/01/1989 - "It is concluded that oxcarbazepine has potent antineuralgic properties in the absence of significant side effects and therefore may be useful in the management of intractable trigeminal neuralgia."
02/01/2002 - "This study therefore aimed to assess long-term outcome in patients with intractable trigeminal neuralgia treated with oxcarbazepine and later with surgery. "
11/21/2007 - "After months of successful analgesic therapy with oxcarbazepine, a 52-year old woman with trigeminal neuralgia suddenly experienced episodes of heavy trigeminal attacks regularly in the evening at about the same time. "
02/01/2002 - "Long-term cohort study comparing medical (oxcarbazepine) and surgical management of intractable trigeminal neuralgia."
01/01/1990 - "Oxcarbazepine, a new drug with antineuralgic properties has been evaluated in a long-term follow-up of 6 patients (2 males, 4 females; aged 42-77 years; mean 61 years), previously reported on with trigeminal neuralgia. "
|9.||Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
01/01/2013 - "Therapeutic efficacy and safety of botulinum toxin type A in trigeminal neuralgia: a systematic review."
07/07/2015 - "Botulinum toxin type A is safe and effective in the treatment of idiopathic trigeminal neuralgia for the patients older than 70 years and the dosages of it are approximate to the patients under 60 years old."
01/01/2014 - "Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial."
04/01/2012 - "Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial."
05/09/2006 - "An open study of botulinum-A toxin treatment of trigeminal neuralgia."
|10.||Lidocaine (Xylocaine)FDA LinkGeneric
02/01/2008 - "This study was undertaken to investigate the clinical outcome of trigeminal nerve block with 10% lidocaine in the management of trigeminal neuralgia (TN). "
05/01/2014 - "Immediate analgesic effect of 8% lidocaine applied to the oral mucosa in patients with trigeminal neuralgia."
01/01/2010 - "Lidocaine is a local anesthetic frequently used to relieve the symptoms of trigeminal neuralgia. "
02/01/2008 - "Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia."
02/01/2007 - "Lidocaine intranasal spray for treatment of trigeminal neuralgia."
09/01/2013 - "Trigeminal neuralgia (TN) surgical treatment with microvascular decompression is highly effective and safe, but for a percentage of patients who undergo this procedure, no vascular compression is found. "
03/01/2002 - "Trigeminal neuralgia is known to be caused by vascular compression at the trigeminal root entry zone (REZ) and microvascular decompression provides good outcome in most of cases. "
01/01/2015 - "Microvascular decompression of the TN is an effective treatment for trigeminal neuralgia, however in some cases, in which vascular compression is not evident when exploring the cerebellopontine angle, it is important to note that association of a prominent ST can hide a vascular compression of the nerve in this region."
01/01/2015 - "Despite the proven efficacy and safety of microvascular decompression (MVD) for the treatment of trigeminal neuralgia, some physicians are reluctant to perform the procedure in elderly patients because of potential complications. "
10/01/2014 - "The microvascular decompression procedure has proven to be a safe and effective option in the surgical management of neurovascular compression syndromes in general and trigeminal neuralgia in particular. "
01/01/2006 - "Frame-based radiosurgical rhizotomy has been shown in clinical studies to be effective for managing trigeminal neuralgia (TN). "
01/01/1985 - "Among the 26 recurrent trigeminal neuralgia following retrogasserian rhizotomy, RFTC was effective in 23 cases (88.5%), and in 3 cases (11.5%) RFTC was effective for a short period. "
06/01/2003 - "The purpose of this study was to evaluate the efficacy of radiofrequency trigeminal rhizotomy in treating 135 patients harboring trigeminal neuralgia, and to introduce a technical modification to guide the puncture of the foramen ovale. "
07/23/1982 - "Treatment by PRGI is a valid alternative therapy for tic douloureux, with the additional benefit of a much-reduced incidence of facial sensory loss when compared with differential thermal rhizotomy by a radiofrequency-induced lesion technique. "
03/01/2015 - "BACKGROUND/STUDY AIMS: Percutaneous radiofrequency trigeminal rhizotomy (RTR) is a standardized treatment for trigeminal neuralgia, yet it has been associated with serious complications related to the cannulation of the foramen ovale. "
08/01/2012 - "The clinical efficacy of radiofrequency thermocoagulation in the treatment of idiopathic trigeminal neuralgia is good and reliable. "
09/01/2009 - "CT fluoroscopy-guided percutaneous radio-frequency thermocoagulation of the Gasserian ganglion was safe, quick, and effective for patients with intractable idiopathic trigeminal neuralgia."
01/01/1980 - "Trigeminal thermocoagulation is safe and effective in relieving recurrent trigeminal neuralgia in patients who have had a previous intra-cranial operation for their symptoms."
09/01/2014 - "To investigate the clinical efficacy of X-ray imaging combined with skin stimulation potential-guided percutaneous radiofrequency thermocoagulation of the Gasserian ganglion for treatment of primary trigeminal neuralgia. "
08/01/2012 - "To analyze the clinical efficacy of radiofrequency thermocoagulation in the treatment of idiopathic trigeminal neuralgia, and discuss the method, skill of radiofrequency thermocoagulation and complications. "
|4.||Drug Therapy (Chemotherapy)
12/01/2004 - "Although antiepileptic drug therapy may be beneficial in the treatment of trigeminal neuralgia, up to one-half of the patients become refractory or intolerant to these medications. "
05/01/1985 - "Trigeminal neuralgia nearly always can be relieved initially with drug therapy. "
06/01/2015 - "Idiopathic trigeminal neuralgia (iTN) is a neurological condition treated with pharmacotherapy or neurosurgery. "
06/01/2012 - "Drug therapy is considered to be the first-line of treatment for trigeminal neuralgia. "
02/01/2012 - "Stereotactic radiosurgery is one of a number of recognised treatments for the management of trigeminal neuralgia refractory to drug therapy. "
01/01/2015 - "The results suggest that stereotactic radiosurgery with linear accelerators could constitute an effective and safe therapeutic alternative for drug-resistant trigeminal neuralgia. "
11/01/2004 - "Linear accelerator-based radiosurgery with the Novalis device is a safe and effective method of managing trigeminal neuralgia and may become the preferred means at centers where the technology is available."
10/01/2003 - "Dedicated linear accelerator-based stereotactic radiosurgery that uses a 5-mm collimator to deliver 90 Gy to the nerve root entry zone is a safe and effective method for the treatment of essential trigeminal neuralgia. "
09/01/2003 - "In this study the authors evaluate the efficacy of and complications associated with dedicated linear accelerator (LINAC) radiosurgery for trigeminal neuralgia (TN). "
01/01/2011 - "The objective of this study was to retrospectively evaluate our institutional results in the management of patients with idiopathic trigeminal neuralgia treated with linear accelerator SRS. "