Trichodermin

Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and antineoplastic; used as tool in cellular biochemistry.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lee, Tzong-Huei: 3 articles (09/2022 - 10/2013)
2.	Wang, Shih-Wei: 3 articles (09/2022 - 10/2013)
3.	Chen, Hsien-Lin: 1 article (09/2022)
4.	Lee, Chien-Hsing: 1 article (09/2022)
5.	Leung, Wan: 1 article (09/2022)
6.	Lin, Chieh-Liang: 1 article (09/2022)
7.	Lin, In-Pin: 1 article (09/2022)
8.	Lin, Mei-Ying: 1 article (09/2022)
9.	Lo, Yi-Hao: 1 article (09/2022)
10.	Chen, Yi Charlie: 1 article (05/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2013 - "This is the first study to investigate the anti-tumor activity of trichodermin (trichothec-9-en-4-ol, 12,13-epoxy-, acetate), an endophytic fungal metabolite from N. " 05/09/2021 - "In addition, trichodermin decelerated tumor growth in BALB/c nude mice, proving its effectiveness in vivo. " 05/09/2021 - "Normal ovarian IOSE 346 cells were much less susceptible to trichodermin than the cancer cell lines. " 01/01/2021 - "Trichodermin has also been shown to selectively induce cell apoptosis in several cancer cell lines and thus can act as a potential lead compound for developing anticancer therapeutics. " 05/09/2021 - "Trichodermin Induces G0/G1 Cell Cycle Arrest by Inhibiting c-Myc in Ovarian Cancer Cells and Tumor Xenograft-Bearing Mice."
2.	Mitochondrial Diseases (Mitochondrial Disease) 09/01/2022 - "Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling." 10/15/2013 - "Trichodermin induces cell apoptosis through mitochondrial dysfunction and endoplasmic reticulum stress in human chondrosarcoma cells." 10/15/2013 - "Together, this study demonstrates that trichodermin is a novel anti-tumor agent against human chondrosarcoma cells both in vitro and in vivo via mitochondrial dysfunction and ER stress. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2017 - "Trichodermin exhibited antiproliferative effects against pancreatic cancer cells, especially p53-mutated cells (MIA PaCa-2 and BxPC-3) rather than normal pancreatic epithelial cells. " 01/01/2017 - "Based on these findings, trichodermin is a potential therapeutic agent worthy of further development into a clinical trial candidate for treating cancer, especially the mutant p53 pancreatic cancer." 01/01/2017 - "In this study, trichodermin, an endophytic fungal metabolite from Nalanthamala psidii, was identified as a potent and selective antitumor agent in human pancreatic cancer. " 01/01/2017 - "Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts." 01/01/2017 - "Importantly, we demonstrated that trichodermin with efficacy similar to gemcitabine, profoundly suppressed tumor growth through inducing intratumoral DNA damage and JNK activation in orthotopic pancreatic cancer model. "
4.	Ovarian Neoplasms (Ovarian Cancer) 05/09/2021 - "In this study, trichodermin (0.5 µM or greater) significantly decreased the proliferation of two ovarian cancer cell lines A2780/CP70 and OVCAR-3. " 05/09/2021 - "These findings suggested that trichodermin has the potential to contribute to the treatment of ovarian cancer." 05/09/2021 - "Overexpression of c-Myc attenuated trichodermin's anti-ovarian cancer activity. " 05/09/2021 - "Trichodermin predominantly inhibited ovarian cancer cells by inducing G0/G1 cell cycle arrest rather than apoptosis. " 05/09/2021 - "However, whether trichodermin is able to suppress ovarian cancer or not was unclear. "
5.	Chondrosarcoma 10/15/2013 - "We demonstrated that trichodermin induced cell apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353 cells) instead of primary chondrocytes. " 10/15/2013 - "Trichodermin induces cell apoptosis through mitochondrial dysfunction and endoplasmic reticulum stress in human chondrosarcoma cells." 10/15/2013 - "Together, this study demonstrates that trichodermin is a novel anti-tumor agent against human chondrosarcoma cells both in vitro and in vivo via mitochondrial dysfunction and ER stress. " 10/15/2013 - "Furthermore, trichodermin induced the upregulation of Bax and Bid, the downregulation of Bcl-2, and the dysfunction of mitochondria, which released cytochrome c and activated caspase-3 in human chondrosarcoma. "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)
2.	Proteins (Proteins, Gene)
3.	Caspase 3 (Caspase-3)
4.	JNK Mitogen-Activated Protein Kinases
5.	Cytochromes c (Cytochrome c)
6.	Sodium Azide
7.	2,4-Dinitrophenol (2,4 Dinitrophenol)
8.	Uncoupling Agents
9.	Sesquiterpenes
10.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)

Related Therapies and Procedures

1.	Therapeutics