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Tricarboxylic Acids

Organic compounds that are acyclic and contain three acid groups. A member of this class is citric acid which is the first product formed by reaction of pyruvate and oxaloacetate. (From Lehninger, Principles of Biochemistry, 1982, p443)
Also Known As:
Acid, Tricarboxylic; Acids, Tricarboxylic; Tricarboxylic Acid
Networked: 423 relevant articles (6 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rabinowitz, Joshua D: 5 articles (11/2022 - 08/2010)
2. Pacak, Karel: 5 articles (01/2018 - 08/2015)
3. Frezza, Christian: 4 articles (10/2017 - 03/2013)
4. Gottlieb, Eyal: 4 articles (12/2015 - 05/2007)
5. Chen, Yibing: 4 articles (09/2015 - 12/2014)
6. Xing, Jinliang: 4 articles (09/2015 - 12/2014)
7. Guo, Jessie Yanxiang: 3 articles (11/2022 - 03/2011)
8. Newgard, Christopher B: 3 articles (03/2021 - 03/2002)
9. DeBerardinis, Ralph J: 3 articles (01/2021 - 11/2018)
10. Fan, Jing: 3 articles (12/2020 - 03/2011)

Related Diseases

1. Obesity
2. Sepsis (Septicemia)
3. Body Weight (Weight, Body)
12/01/1981 - "At the highest dose of 6AN used (35 mg/kg body weight) there was a significant decrease in the 14CO2 yields via the pentose phosphate pathway, the glycolytic route, tricarboxylic acid (TCA) cycle, and via the glutamate-gamma-aminobutyric acid pathway. "
12/01/2017 - "In the absence of UCP1, beige fat dynamically expends glucose through enhanced glycolysis, tricarboxylic acid metabolism and pyruvate dehydrogenase activity for ATP-dependent thermogenesis through the SERCA2b pathway; beige fat thereby functions as a 'glucose sink' and improves glucose tolerance independently of body weight loss. "
07/14/2020 - "IOE and IOP effectively improved the obesity of mice, including the adjustment of body weight gain, energy intake, energy efficiency, liver glucose metabolism and triglyceride metabolism, tricarboxylic acid (TCA) cycle, and degradation of three major nutrients (carbohydrate, lipid, and protein). "
01/01/1988 - "A rise in blood and liver acetaldehyde concentrations following an intragastric administration of ethanol to rats was significantly inhibited when the quinone derivatives 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone (ubidecarenone, coenzyme Q10), 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) were injected intraperitoneally, prior to ethanol load, at a dose of 10, 11.5 and 30 mg/kg of body weight, respectively. "
02/01/2011 - "B(a)P (50 mg/kg body weight)-induced mitochondrial abnormalities was evident from alterations in mitochondrial lipid peroxides, antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, reduced glutathione, vitamin E, and vitamin C), major tricarboxylic acid (TCA) cycle enzyme activities (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase), electron transport chain (ETC) complexes activities and ATP levels. "
4. Colonic Neoplasms (Colon Cancer)
5. Acidosis

Related Drugs and Biologics

1. Lipids
2. Enzymes
3. Lactic Acid (Lactate)
4. Glucose (Dextrose)
5. Pyruvic Acid (Pyruvate)
6. Triglycerides (Triacylglycerol)
7. Proteins (Proteins, Gene)
8. Adenosine Triphosphate (ATP)
9. Carbohydrates
10. Azoxymethane

Related Therapies and Procedures

1. Ketogenic Diet
2. Therapeutics
3. Punctures
4. Ligation
5. Lasers (Laser)