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Transposition of Great Vessels (Great Vessels Transposition)

A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Also Known As:
Great Vessels Transposition; Dextro-Looped Transposition of the Great Arteries; Transposition of Great Arteries; Dextro Looped Transposition of the Great Arteries; Great Arteries Transposition; Great Arteries Transpositions; Great Vessels Transpositions
Networked: 132 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Bronchitis
2. Tetralogy of Fallot (Fallot Tetralogy)
3. Hypoplastic Left Heart Syndrome
4. Ventricular Heart Septal Defects (Ventricular Septal Defect)
5. Double Outlet Right Ventricle

Experts

1. Choudhary, Shiv Kumar: 3 articles (01/2012 - 11/2002)
2. Kothari, Shyam Sunder: 3 articles (01/2012 - 11/2002)
3. Czeizel, Andrew E: 2 articles (10/2015 - 10/2013)
4. Vereczkey, Attila: 2 articles (10/2015 - 10/2013)
5. Morgan, John: 2 articles (09/2015 - 02/2008)
6. Sharma, Rajesh: 2 articles (04/2015 - 11/2002)
7. Sípek, A: 2 articles (10/2012 - 12/2008)
8. Langhammer, P: 2 articles (10/2012 - 12/2008)
9. Gregor, V: 2 articles (10/2012 - 12/2008)
10. Saxena, Anita: 2 articles (01/2012 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Transposition of Great Vessels:
1. Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link
2. PlasticsIBA
3. Hereditary renal agenesisIBA
12/01/2008 - "Mean incidences (per 10,000 live births) and prenatal diagnostics rate (%, in brackets) were as follows: anencephaly 2.81 (95.65), spina bifida 4.13 (61.12), encephalocele 0.99 (77.04), congenital hydrocefalus 4.32 (49.61), omfalocele 2.59 (54.97), gastroschisis 2.88 (77.30), diafragmatic hernia 2.40 (22.02), cystic kidney 5.16 (24.80), renal agenesis/hypoplasia 5.02 (25.97), transposition of great vessels 6.93 (7.85), tetralogy of Fallot 6.28 (5.87), hypoplastic left heart syndrome 4.63 (39.86) and coarctation of aorta 8.46 (3.80). "
01/01/2005 - "Included were all live births, fetal deaths and terminations of pregnancy diagnosed with one or more of the following malformations: anencephalus, encephalocele, spina bifida, hydrocephalus, transposition of great arteries, hypoplastic left heart, limb reduction defect, bilateral renal agenesis, diaphragmatic hernia, omphalocele and gastroschisis. "
12/01/2008 - "Following total numbers of particular birth defects were registered during the 1994-2007 period: anencephaly 380, spina bifida 559, encephalocele 1134, congenital hydrocefalus 584, omfalocele 351, gastroschisis 389, diafragmatic hernia 325, cystic kidney 698, renal agenesis/hypoplasia 679, transposition of great vessels 797, tetralogy of Fallot 723, hypoplastic left heart syndrome 533 and coarctation of aorta 973. "
12/01/2008 - "Total numbers and mean incidences of selected types of defects (anencephaly, spina bifida, encephalocele, congenital hydrocefalus, omfalocele, gastroschisis, diafragmatic hernia, cystic kidney, renal agenesis/hypoplasia, transposition of great vessels, tetralogy of Fallot, hypoplastic left heart syndrome and coarctation of aorta) during the period under the study were analyzed. "
4. Neural tube defects X-linkedIBA
5. 1,2-didecanoyl-3-phosphatidic acid (PA(10))IBA
6. beta-cyclodextrin tetradecasulfate (CTDS)IBA
7. Pulmonary venous return anomalyIBA
8. Coarctation of the aortaIBA
9. Complete atrioventricular septal defectIBA
01/01/1998 - "Two-stage correction of transposition of great arteries with complete atrioventricular canal."
06/01/1992 - "[Biventricular repair for right isomerism associated with transposition of great arteries and common atrioventricular canal]."
12/01/2001 - "The numbers describe in the following order patient years (y), number of patients (n), and freedom from reoperation at follow-up interval (%), respectively: atrial septal defect (15,864y, n=1198, 99+/-0/99+/-0/99+/-0), partial atrioventricular septal defect (2506y, n=234, 95+/-2/93+/-2/93+/-2), total anomalous pulmonary venous connection (742y, n=141, 93+/-1/91+/-0/91+/-0), complete atrioventricular septal defect (1715y, n=377, 81+/-3/76+/-3/72+/-4), tetralogy of Fallot <1 year (1503y, n=197, 94+/-4/85+/-1/74+/-3), transposition of great arteries (1459y, n=375, 88+/-2/83+/-4/73+/-7), interrupted aortic arch (IAA) (481y, n=98, 63+/-6/52+/-7/45+/-8), common arterial trunk (CAT) (599y, n=109, 64+/-6/24+/-6/11+/-5). "
06/01/1992 - "A 5-years old boy, whose thoracic situs was right isomerism, was diagnosed as transposition of great arteries, common atrioventricular canal (intermediate type), severe tricuspid valve regurgitation, pulmonary valve stenosis, bilateral superior vena cava and left sided inferior vena cava. "
01/10/2003 - "The experience of surgical treatment of 8 newborns with critical congenital heart diseases, including 3 cases of D-transposition of great arteries with intact ventricular septum, 2 cases of ventricular septal defect with artrial defect (ASD), one case of complete atrioventricular canal defect, 1 case of obstructed supracardiac total anomalous pulmonary venous drainage with ASD, and 1 case of patent ductus arteriosus (PDA). "
10. Conotruncal cardiac defectsIBA
01/01/2014 - "Conotruncal cardiac defects except transposition of great arteries were strongly associated with 22q11.2 deletion. "
05/01/2012 - "We studied 31 normal fetuses and 28 fetuses with congenital heart disease (6 with double-outlet right ventricle, 5 with complete transposition of great arteries, 8 with tetralogy of Fallot, 3 with right aortic arch, 2 with persistent left superior vena cava, 3 with truncus arteriosus communis, and 1 with interruption of aortic arch) at gestation ages ranging from 18 to 39 weeks using transabdominal 4D B-flow sonography with STIC (4D BF-STIC). "
10/01/2008 - "We prospectively enrolled 214 children with conotruncal defects: 126 with tetralogy of Fallot (TOF), 18 with pulmonary atresia-ventricular septal defect (PA-VSD), 15 with truncus arteriosus communis (TAC) type I, one with interrupted aortic arch (IAA) type B, and 54 with the transposition of great arteries, who were consecutively hospitalized at the Pediatric Cardiology Department between 2003 and 2005. "
04/01/1997 - "The CCVDs comprised complex conotruncal defects such as tetralogy of Fallot, double outlet right ventricle, transposition of great arteries and truncus arteriosus communis, or anomalies of the derivatives of the branchial arch arteries in association with a ventricular septal defect, including one case of atresia of the ductus arteriosus with pulmonary artery aneurysm and resulting in fetal hydrops. "
01/01/2000 - "Cardiac diagnoses included patent ductus arteriosus (PDA) (N = 21, 28.7%), ventricular septal defect (VSD) (N = 9, 12.3%), transposition of great arteries (TGA) (N = 10, 13.7%), tetralogy of Fallot (TOF) (N = 7, 9.6%), double-outlet right ventricle (DORV) (N = 4, 5.5%), truncus arteriosus communis (TAC) (N = 4, 5.5%), hypoplastic left heart syndrome (HLHS) (N = 4, 5.5%), coarctation of aorta (CoAo) (N = 6, 8.2%), total anomalous pulmonary venous return (TAPVR) (N = 2, 2.7%), aortic stenosis (AoVS) (N = 3, 4.1%), interrupted aortic arch (IAA) (N = 1, 1.4%), pulmonary atresia (PA) (N = 1, 1.4%) and common atrioventricular canal (CAVC) (N = 1, 1.4%). "

Therapies and Procedures

1. Fontan Procedure (Fontan Operation)
2. Patient Readmission
3. Transplants (Transplant)
4. Heart Transplantation (Grafting, Heart)
5. Palliative Care (Palliative Medicine)