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Transposition of Great Vessels (Great Vessels Transposition)

A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Also Known As:
Great Vessels Transposition; Dextro-Looped Transposition of the Great Arteries; Transposition of Great Arteries; Dextro Looped Transposition of the Great Arteries; Dextro TGA; Dextro-TGAs; Great Arteries Transposition; Great Arteries Transpositions; Great Vessels Dextrotransposition; Great Vessels Dextrotranspositions; Great Vessels Levotransposition; Great Vessels Levotranspositions; Great Vessels Transpositions; Levo Looped Transposition of the Great Arteries; Levo TGA; Levo-TGAs; Dextro-TGA; Dextrotransposition of Great Vessels; Levo-Looped Transposition of the Great Arteries; Levo-TGA; Levotransposition of Great Vessels
Networked: 253 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Ventricular Heart Septal Defects (Ventricular Septal Defect)
2. Tetralogy of Fallot (Fallot Tetralogy)
3. Atrial Heart Septal Defects (Atrial Septal Defect)
4. Hypoplastic Left Heart Syndrome
5. Pulmonary Hypertension

Experts

1. Choudhary, Shiv Kumar: 6 articles (11/2016 - 11/2002)
2. Kothari, Shyam Sunder: 6 articles (11/2016 - 11/2002)
3. Saxena, Anita: 6 articles (11/2016 - 11/2002)
4. Talwar, Sachin: 5 articles (02/2019 - 03/2011)
5. Chauhan, Sandeep: 5 articles (01/2016 - 12/2010)
6. Sharma, Rajesh: 4 articles (12/2022 - 11/2002)
7. Airan, Balram: 4 articles (11/2016 - 03/2011)
8. Juneja, Rajnish: 4 articles (11/2016 - 11/2002)
9. Aggarwal, Sanjeev: 3 articles (12/2022 - 10/2015)
10. Bhan, Anil: 3 articles (12/2022 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Transposition of Great Vessels:
1. Oxygen (Dioxygen)IBA
2. Brain Natriuretic Peptide (Natrecor)FDA Link
3. beta-cyclodextrin tetradecasulfate (CTDS)IBA
4. Lamotrigine (Lamictal)FDA LinkGeneric
5. 1,2-didecanoyl-3-phosphatidic acid (PA(10))IBA
6. Anesthetics (Anesthetic Agents)IBA
7. Coenzyme A (CoA)IBA
11/12/2013 - "60 age- and BSA-matched subjects--20 post-aortic coarctation (CoA) repair, 20 transposition of great arteries post arterial switch operation (ASO) and 20 healthy controls--had a three-dimensional (3D), whole heart magnetic resonance angiography (MRA) at 1.5 Tesla, 3D geometric reconstructions created from the MRA. "
11/15/2023 - "The CHD noted in these twin pairs included ToF (n = 2), CoA (n = 4), corrected transposition of great arteries (ccTGA) (n = 2), truncus arteriosus (n = 2), complete common atrioventricular canal (CCAVC) (n = 2), hypoplastic left heart syndrome (HLHS) (n = 2), Shone's complex (n = 1), and hypoplastic right heart syndrome (HRHS) (n = 1). "
11/08/2017 - "Three hundred and fifty-four cases of four major CHDs, including functionally univentricular heart (FUH, N=132), d-transposition of great arteries (d-TGA, N=85), tetralogy of Fallot (TOF, N=60) and coarctation of aorta (CoA, N=77). "
10/01/2002 - "The FMCG was analysed and compared to the postnatal ECG in eight cases of CHD: atrial septal defect ASDII (three cases), a combination of atrioventricular-septal-defect (AVSD) and Tetralogy of Fallot (TOF) (one case ), complete transposition of great arteries (d-TGA) (two cases), coarctation of aorta (COA) (one case), stenosis of the pulmonary artery (PS) and right ventricular hypoplasia (one case). "
05/01/2010 - "Ventricular septal defect (VSD; 4.0) was the most common defect, followed by secundum atrial septal defect (ASDII; 3.2), patent ductus arteriosus (PDA; 2.0), pulmonary stenosis (PS; 1.2), tetralogy of Fallot (TOF; 0.63), coarctation of aorta (CoA; 0.25), transposition of great arteries (TGA; 0.21), endocardial cushion defect (ECD; 0.20), double outlet of right ventricle (DORV; 0.15), total anomalous pulmonary venous return (TAPVR; 0.11), aortic stenosis (0.09), hypoplastic left heart syndrome (HLHS; 0.062), Ebstein anomaly (0.047), and tricuspid atresia (0.046). "
8. Biomarkers (Surrogate Marker)IBA
9. Tretinoin (Retinoic Acid)FDA LinkGeneric
10. ProstaglandinsIBA

Therapies and Procedures

1. Arterial Switch Operation
2. Therapeutics
3. Fontan Procedure (Fontan Operation)
4. Patient Readmission
5. Heart Transplantation (Grafting, Heart)