|1.||Coy, Johannes F: 10 articles (01/2013 - 01/2005)|
|2.||Zhang, Song: 5 articles (01/2009 - 04/2007)|
|3.||Cascante, Marta: 4 articles (01/2011 - 02/2006)|
|4.||Frederiks, Wilma M: 4 articles (06/2009 - 02/2006)|
|5.||Kämmerer, Ulrike: 3 articles (01/2015 - 12/2007)|
|6.||Lonsdale, Derrick: 3 articles (01/2015 - 08/2002)|
|7.||Obrenovich, Mark E: 3 articles (01/2015 - 03/2003)|
|8.||Coy, J F: 3 articles (01/2013 - 02/2006)|
|9.||Stickeler, Elmar: 3 articles (12/2011 - 04/2007)|
|10.||Zur Hausen, Axel: 3 articles (12/2011 - 04/2007)|
08/23/1979 - "Thus, thiamine deficiency, established as a significant reduction of red blood cell transketolase activity, seems to have a deleterious effect on the peripheral nerves and muscles. "
02/01/2015 - "Erythrocyte transketolase testing has shown that thiamine deficiency is widespread. "
01/01/2014 - "Downregulation of transketolase activity is related to inhibition of hippocampal progenitor cell proliferation induced by thiamine deficiency."
01/01/2011 - "Blood samples taken from 16 cases prior to treatment showed increased levels of erythrocyte transketolase activation coefficient, consistent with thiamine deficiency. "
10/01/2010 - "Confirming thiamine deficiency is problematic and relies on demonstrating reduced red blood cells transketolase activity, or indirect methods including urinary organic acid analysis and dietary analysis. "
01/01/2011 - "Based on studies performed with a selected mouse monoclonal anti-transketolase- like (TKTL)-1 antibody (clone JFC12T10), overexpression of TKTL-1 has been shown to be correlated with poor survival and increased metastatic spread in several human tumor entities. "
02/05/2010 - "In this study, we investigated the effect of inhibition of the transketolase pathway on signaling pathways in MIA PaCa cancer cells using in-house proteomic techniques. "
11/01/2015 - "It is well known that tumor cells mainly depend on the nonoxidative pathway of the pentose phosphate pathway (PPP), and transketolase-like 1 (TKTL1), a kind of crucial metabolism enzyme, participates in the regulation of PPP; notably, overwhelming evidence has demonstrated that TKTL1 plays pivotal roles in the development and progression of multiple tumors. "
09/01/2013 - "Transketolase-like protein 1 (TKTL1), which has an important role in controlling the nonoxidative pentose-phosphate pathway, is significantly overexpressed in several different tumor entities. "
03/01/2013 - "Until recently it was assumed that the transketolase-like protein (TKTL1) detected in the tumor tissue, is catalytically active mutant form of human transketolase (hTKT). "
10/01/1985 - "Feeding of a thiamine-deficient diet to adult rats resulted in 5-7 weeks in ataxia and loss of righting reflex accompanied by decreased blood transketolase activities. "
08/01/1987 - "There were no laboratory or physiological markers for ataxia, including hemoglobin A1a + b, red blood cell transketolase, liver function enzymes, and measures of reaction time and hand-eye coordination. "
03/01/2010 - "This includes evidence of abnormal pyruvate metabolism reversed by thiamine in patients with TAN, evidence from erythrocyte transketolase activity indicating significant thiamine deficiency in patients with TAN compared to controls, and a placebo-controlled trial of therapeutic doses of thiamine which showed a clinically dramatic and statistically significant improvement in ataxia. "
|4.||Wernicke Encephalopathy (Wernicke's Encephalopathy)
01/01/1986 - "Recent data demonstrating normal levels of erythrocyte transketolase in patients presenting with Wernicke's encephalopathy has led some to question the link between thiamin deficiency, and the development of the syndrome, despite the fact that virtually all patients with Wernicke's encephalopathy will respond favorably to parenteral thiamin, and the evidence that rats deprived of thiamin develop lesions that are characteristic of the disease. "
11/01/1986 - "We found that the above-mentioned patient and one of the diabetic kindreds with no history of Wernicke's encephalopathy had abnormal transketolase as determined by its Km for TPP. "
11/30/1990 - "The relationship between erythrocyte transketolase activity and the 'TPP effect' in Wernicke's encephalopathy and other thiamine deficiency states."
07/01/2002 - "Both patients were diagnosed with Wernicke's encephalopathy on clinical ground since there were no laboratory facilities to measure red cell transketolase and thiamine pyrophosphate levels. "
07/01/1999 - "Also discussed are new findings on the molecular genetics of the thiamine-dependent enzyme transketolase in patients with Wernicke encephalopathy. "
|5.||Chronic Kidney Failure (Chronic Renal Failure)
06/01/2000 - "No correlation between erythrocyte TDP concentration and transketolase activity and/or alpha-ETK was observed in ESRD patients, either before or 10 h after administration. "
07/01/1984 - "[Catalytic activity of transketolase in erythrocytes in chronic kidney failure]."
11/01/1971 - " findings demonstrate that in patients with chronic renal failure, low molecular weight factors accumulate and inhibit nervous tissue transketolase. "
06/01/2000 - "Compared with thiamine nitrate, the oral administration of benfotiamine leads to higher TDP concentrations in erythrocytes accompanied with a significant improvement of the erythrocyte transketolase activity in ESRD patients."
01/01/2000 - "[The effect of cocarboxylase treatment on erythrocyte transketolase and blood thiamine in patients with end stage renal disease undergoing maintenance hemodialysis]."
|3.||Pyruvic Acid (Pyruvate)
|5.||Transcription Factors (Transcription Factor)
|6.||Poly Adenosine Diphosphate Ribose
|2.||Renal Dialysis (Hemodialysis)
|3.||Protein-Restricted Diet (Diet, Protein Restricted)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Transplantation (Transplant Recipients)