Transcription Factors (Transcription Factor)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Also Known As:
Transcription Factor; Factor, Transcription; Factors, Transcription
Networked: 20597 relevant articles (155 outcomes, 1407 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Aggarwal, Bharat B: 54 articles (01/2014 - 08/2002)
2. Johnson, Randall S: 48 articles (08/2015 - 03/2002)
3. Eckardt, Kai-Uwe: 36 articles (08/2015 - 05/2002)
4. Stein, Gary S: 34 articles (10/2015 - 12/2002)
5. Yamamoto, Masayuki: 33 articles (08/2015 - 05/2002)
6. Harris, Adrian L: 31 articles (10/2015 - 02/2002)
7. Lian, Jane B: 30 articles (10/2015 - 12/2002)
8. Tenen, Daniel G: 28 articles (10/2015 - 01/2002)
9. van Wijnen, Andre J: 26 articles (10/2015 - 02/2005)
10. Ratcliffe, Peter J: 26 articles (06/2015 - 07/2002)

Related Diseases

1. Neoplasms (Cancer)
05/28/2001 - "This approach is now rendered possible by major advances along several lines of investigation: (i) the possibility of analysing gene expression through high throughput methods; (ii) a more detailed knowledge of the regulatory regions and of the transcription factors that control gene expression also facilitated in the future by a comprehensive whole genome comparative analysis of these regulatory sequences; (iii) the ability of modulating gene expression at the single gene level through various approaches both pharmacological and biochemical; (iv) the opportunity of directly antagonizing the aberrant activities of oncogenic transcription factors through a detailed knowledge of their abnormal transcriptional function; (v) the possibility of validating, in vivo, in animal models the relevance for neoplastic transformation of specific transcriptional events as well as of testing the efficacy of 'transcription therapy' in faithful animal models of human cancer. "
01/01/2015 - "Targeting pluripotency transcription factors, SOX2, OCT4, and Nanog homeobox, demonstrates promising therapeutic potential that if applied in isolation or together with current treatments may improve overall survival, reduce tumor relapse, and achieve a cure for these patients. "
09/01/2013 - "Importantly, OCT4, NANOG, and SOX2 provide great promise for clinical applications because reducing their expression or blocking the pathways in which they function may inhibit tumor growth and turn-off the cancer "switch." In the future, a clear understanding of transcription factor regulation will be essential for elucidating the roles of OCT4, NANOG, and SOX2 in tumorigenesis, as well as exploring their use for diagnostic and therapeutic purposes. "
06/15/2004 - "Improved understanding of how transcription factors affect cancer biology may lead to improved ability to predict clinical outcome and discovery of novel therapeutic strategies. "
02/01/2014 - "Recently, a large number of drugs have been identified that inhibit one or both transcription factors with promising results in terms of controlling tumor progression. "
2. Inflammation
3. Anoxia (Hypoxia)
4. Shock
5. Bipolar Disorder (Mania)

Related Drugs and Biologics

1. NF-kappa B (NF-kB)
2. Cytokines
3. Proteins (Proteins, Gene)
4. Transcription Factor AP-1 (Transcription Factor AP 1)
5. Transcription Factors (Transcription Factor)
6. Lithium
7. Oxygen
8. STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
9. Enzymes
10. Curcumin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Transplants (Transplant)
3. Immunotherapy
4. Radiotherapy
5. Homologous Transplantation (Allograft)