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Ocular Toxoplasmosis

Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.
Also Known As:
Toxoplasmosis, Ocular; Ocular Toxoplasmoses; Toxoplasmoses, Ocular
Networked: 388 relevant articles (25 outcomes, 44 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Toxoplasmosis
2. Infections
3. Encephalitis (Encephalitis, Rasmussen)
4. Choroidal Neovascularization
5. Cysts

Experts

1. de-la-Torre, Alejandra: 11 articles (01/2021 - 10/2009)
2. Belfort, Rubens: 9 articles (01/2022 - 08/2003)
3. Smith, Justine R: 8 articles (01/2021 - 12/2002)
4. Candolfi, Ermanno: 8 articles (01/2019 - 08/2003)
5. Garweg, Justus G: 7 articles (10/2021 - 10/2004)
6. Pfaff, Alexander W: 7 articles (01/2019 - 04/2009)
7. Muccioli, Cristina: 7 articles (01/2018 - 08/2003)
8. Furtado, João M: 6 articles (01/2021 - 01/2013)
9. Rochet, Elise: 6 articles (01/2021 - 01/2019)
10. Villard, Odile: 6 articles (01/2019 - 08/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ocular Toxoplasmosis:
1. Clindamycin (Cleocin)FDA LinkGeneric
2. Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric
3. Pyrimethamine (Daraprim)FDA Link
4. Sulfadiazine (Sulphadiazine)FDA Link
5. Azithromycin (Zithromax)FDA LinkGeneric
6. Immunoglobulin G (IgG)IBA
7. AntibodiesIBA
8. Immunoglobulin M (IgM)IBA
9. Anti-Bacterial Agents (Antibiotics)IBA
10. Atovaquone (Mepron)FDA Link

Therapies and Procedures

1. Therapeutics
01/01/1993 - " The need for appropriate therapy for patients with ocular toxoplasmosis is a matter of continued debate: the majority of the medications used for treatment have potentially serious side effects and the efficacy of treatments has not been clarified in previous studies. "
06/01/2013 - "Intravitreal clindamycin+dexamethasone and conventional treatment with oral pyrimethamine+sulphadiazine had similar efficacy with regard to all outcome measures in ocular toxoplasmosis, and intravitreal therapy was found to be safe. "
03/05/2021 - "A systematic literature search was performed in NCBI/PubMed, Clinical Trials, Google Scholar and ScienceDirect to retrieve pro- and retrospective studies using the key terms "ocular toxoplasmosis" or "retinochoroiditis" and "immunocompetent" and "treatment" or "therapy" and "human." Of these, larger case series and prospective clinical studies and cross references identified from meta-analyses were selected by a manual search, and primary and secondary outcome parameters were extracted. "
03/01/1999 - "The murine model reproduces some features of ocular toxoplasmosis in humans and may be suitable for large-scale controlled studies of the pathogenesis and therapeutics of acquired ocular toxoplasmosis as well as for study of the mechanisms of immune privilege in the eye."
09/01/2022 - "In addition, laboratory analysis, comanagement with other specialists, and evaluating the response to antitoxoplasma therapy were all instrumental in the eventual diagnosis and treatment of ocular toxoplasmosis in this atypical case."
2. Intravitreal Injections
3. Vitrectomy
4. Intraocular Injections
5. Drug Therapy (Chemotherapy)