Toxocariasis

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172 relevant articles (10 outcomes, 16 trials/studies) found for this Disease

Description: Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man.

Also Known As:

Toxocariases

Relationship Network

Disease Context: Research Results

Parasitic Diseases: 561

Helminthiasis: 275

Nematode Infections: 411

Secernentea Infections

Ascaridida Infections

Toxocariasis: 172

Visceral Larva Migrans: 63

Animal Helminthiasis: 1

Toxocariasis: 172

Animal Parasitic Diseases

Animal Helminthiasis: 1

Toxocariasis: 172

Animal Diseases: 119

Animal Parasitic Diseases

Animal Helminthiasis: 1

Toxocariasis: 172

Related Diseases

1.	Visceral Larva Migrans
2.	Folliculitis (Sycosis)
3.	Infection
4.	Eosinophilia
5.	Retinal Detachment (Retinal Detachments)

Experts

1.	Fabre, R: 2 articles (12/2006 - 12/2002)
2.	Morassin, B: 2 articles (12/2006 - 12/2002)
3.	Magnaval, J-F: 2 articles (12/2006 - 12/2002)
4.	Chieffi, Pedro Paulo: 2 articles (03/2004 - 01/2004)
5.	Watthanakulpanich, Dorn: 1 article (05/2008)
6.	Whalley, Anthony J: 1 article (05/2008)
7.	Billington, David: 1 article (05/2008)
8.	Hobbs, Glyn: 1 article (05/2008)
9.	Smith, Huw V: 1 article (05/2008)
10.	Zarnowska, H: 1 article (03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Toxocariasis:

1.	AntigensIBA 05/01/1998 - "Larger scale studies are underway to investigate the efficacy of rTc-CPL-1 as a diagnostic antigen for human toxocariasis, the current test for which relies on whole excretory/secretory antigens of cultured parasites." 03/01/2007 - "Thus, ELISA based on TcES-57 antigen was proven to be an effective tool in the diagnosis of toxocariasis and studies on the role of T. " 06/01/1996 - "A study on the seroprevalence of toxocariasis, using ELISA with Toxocara larval excretory-secretory antigens, was carried out on human populations in two regions of Spain. " 01/01/1996 - "Three serological tests: Immunodiffusion (ID), Counterimmunoelectrophoresis (CIEP) and Enzyme-linked immunosorbent assay (ELISA) were used to study the role of crude adult worm antigen (CAWA) of Toxocara canis and each of its purified fractions in the serodiagnosis of human toxocariasis. " 01/01/1985 - "This study was designed to compare the sensitivity and specificity of enzyme linked immunosorbent assay (ELISA) for the serodiagnosis of ocular toxocariasis using Toxocara canis embryonated egg antigen (TEE) and toxocara excretory-secretory or exoantigen (TEX) produced in vitro. " Order ALL the reference details at left...
2.	Immunoglobulin G (IgG)IBA 05/01/2009 - "In conclusion, the EITB-IgG test is a very useful tool to confirm the serological diagnosis of human toxocariasis." 05/01/2009 - "Additionally, when the results of the EITB-IgG test were compared to those of the ELISA-IgG test, a 100% concordance was observed for positive results in human toxocariasis cases. " 12/15/2009 - "When a more thorough history revealed frequent intake of raw cow liver, we diagnosed pulmonary toxocariasis by ELISA for specific serum IgG antibody." 06/01/2009 - "Combined use of rTES-120 and rTES-30 IgG4 ELISA for the diagnosis of toxocariasis provided 100% sensitivity. " 09/01/2008 - "Therefore, it is suggested that the recombinant-AK based IgG-ELISA could be applied for immunodiagnosis of human toxocariasis. " Order ALL the reference details at left...
3.	Mebendazole (Vermin)FDA Link 03/01/1992 - "The authors discuss the results of a double-blind, placebo-controlled, randomised study on the efficacy of mebendazole versus placebo in the treatment of human toxocariasis in 45 and 43 patients respectively, who exhibited evocative clinical and biological symptoms and a seropositivity. " 03/01/1992 - "[Double blind study of the efficacy of mebendazole in minor forms of human toxocariasis]" 01/01/2008 - "In children with toxocariasis its covert form was diagnosed and mebendazole was administered. " 05/01/1995 - "We have studied the action of mebendazole on experimental murine toxocariasis using different formulations and vehicles. " 05/01/1995 - "Evaluation by larval recovery of mebendazole activity in experimental murine toxocariasis." Order ALL the reference details at left...
4.	AntibodiesIBA 05/01/2008 - "A major problem in the serodiagnosis of human toxocariasis in tropical countries is cross-reaction with antibodies to other helminthic diseases and a lack of sensitivity. " 07/01/2005 - "The titers of serum Toxocara antibodies, being 1:800 or higher, may suggest that more than 50% of the total number of the examinees might be, in terms of clinical signs, patients with toxocariasis." 09/01/2004 - "Seroprevalence of Toxocara antibodies among patients suspected of ocular toxocariasis in Slovenia." 12/01/2003 - "Antibody titers in intraocular fluids led to a diagnosis of ocular toxocariasis in eight seronegative cases of 33 cases examined for antibodies in both serum and intraocular fluid samples. " 01/01/2001 - "The significance of the level of antibodies in the evaluation of the effects of treatment of toxocariasis." Order ALL the reference details at left...
5.	Thiabendazole (Mintezol)FDA Link 01/01/2006 - "A serological follow-up study was carried out on 27 children (1-12 years old) with visceral and/or ocular toxocariasis, after treatment with thiabendazole. " 07/01/1996 - "With the hypothesis of Toxocariasis (visceral larva migrans) we administered thiabendazole that brought complete clinical and laboratory remission. " 10/01/1987 - "[Comparative efficacy of thiabendazole and mebendazole in the treatment of toxocariasis]" 10/01/1989 - "Thiabendazole vs. albendazole in treatment of toxocariasis: a clinical trial." 11/01/1983 - "Larval toxocariasis was confirmed by a high level of specific antibodies which failed to decrease even after administration of Mintezol antithelmintic. " Order ALL the reference details at left...
6.	Diethylcarbamazine (Hetrazan)FDA Link 01/01/1993 - ""Covert toxocariasis" in a child treated with low-dose diethylcarbamazine." 01/01/1993 - "A girl aged 2.5 years with "covert toxocariasis" was treated with low-dose diethylcarbamazine because of supposed noticeable disseminated Toxocara canis infection without ocular or visceral manifestations. " 06/01/1995 - "Comparative efficacy of diethylcarbamazine and mebendazole for the treatment of human toxocariasis." 02/01/1982 - "There is no effective specific therapy for toxocariasis, however, treatment with thiabendazole and diethylcarbamazine may be helpful. " 06/01/1995 - "An open randomized study was carried out to assess the efficacy of diethylcarbamazine (DEC) and mebendazole (MBZ) across, respectively, 39 and 41 patients, all exhibiting clinical and biological features evocative of toxocariasis, together with a positive immunodiagnosis by Western blot using Toxocara larvae excretory-secretory antigens. " Order ALL the reference details at left...
7.	Ivermectin (Mectizan)FDA Link 10/01/1998 - "Apparent weak efficacy of ivermectin for treatment of human toxocariasis." 02/01/1987 - "Anthelmintic effect of levamisole hydrochloride or ivermectin on tissue toxocariasis of mice." Order ALL the reference details at left...
8.	Immunoglobulin E (IgE)IBA 01/01/2008 - "The determination of immunoglobulin E and eosinophilic cationic protein concentration may be useful for toxocariasis therapy monitoring." 12/01/2002 - "Western-blot coupled with specific anti-Toxocara IgE detection appeared therefore to be an accurate procedure for the immunodiagnosis of ocular toxocariasis, provided the testing was simultaneously performed on the serum and AF." 12/01/1996 - "The estimation of the immune response included IgE level (antibody mediated mechanism) and the absolute eosinophils count (a manifestation of cell mediated immune response) since eosinophil/IgE/mast cell axis represents a specialized immune mechanism that may contribute directly to parasite damage in toxocariasis (Knight, 1982). " 01/01/1993 - "IgE ELISA might be an interesting complementary method in the diagnosis of toxocariasis." 01/01/1993 - "[Utilization of ELISA IgE method in diagnosis of Toxocariasis in humans]" Order ALL the reference details at left...
9.	TESIBA 12/01/2003 - "The assayed sera were from patients with: cysticercosis (n = 18); toxocariasis (n = 40); schistosomiasis (n = 19) and hydatidosis (n = 50) with proven clinical and laboratory diagnosis, and sera from rabbits immunized with Tso, Tcra-VF, TES and Eg. " 09/01/2008 - "The most common method available for serodiagnosis of toxocariasis is an enzyme-linked immunosorbent assay (ELISA) test using Toxocara excretory-secretory antigen (TES). " 05/01/2002 - "CONCLUSION: A positive antibody response to TES antigen in 6.4% subjects residing in a rural area near Chandigarh and in 23.3% of patients clinically suspected to have toxocariasis indicates that human toxocariasis may be endemic in certain regions of northern India. " 05/01/2002 - "To assess the extent of this problem in northern India, we tested the antibody response to the TES antigen by ELISA technique in subjects residing in a rural area near Chandigarh and in patients attending Nehru hospital, Chandigarh and clinically suspected to have toxocariasis. " 06/01/2009 - "Diagnosis of human toxocariasis currently relies on serologic tests that use Toxocara excretory-secretory (TES) antigen to detect immunoglobulin G (IgG) antibodies to the larvae. " Order ALL the reference details at left...
10.	Peroxidase (Myeloperoxidase)IBA 05/01/2008 - "The majority of tests currently available use total IgG and, in this study, the use of peroxidase-conjugated anti-human IgG subclass antibodies (IgG1-4) was compared with total IgG for the diagnosis of human toxocariasis by using Toxocara excretory-secretory (TES) antigens in an enzyme-linked immunosorbent assay (ELISA) format. " Order ALL the reference details at left...

Therapies and Procedures

1.	Vitrectomy 09/01/2003 - "[Importance of pars plana vitrectomy in the diagnosis of ocular toxocariasis]" 01/01/2001 - "[Pars plana vitrectomy in treatment of ocular toxocariasis complications--case report]" 04/01/1999 - "Pars plana vitrectomy and subretinal surgery for ocular toxocariasis." 01/01/1983 - "Vitrectomy for complications of ocular toxocariasis." 12/01/1982 - "Vitrectomy in ocular toxocariasis." Order ALL the reference details at left...
2.	Traction 01/01/2000 - "Vitrectomy update for macular traction in ocular toxocariasis." 01/01/2000 - "PURPOSE: To study the results of modern vitrectomy in traction and combined traction-rhegmatogenous retinal detachment involving the macula in cases of ocular toxocariasis. " 07/15/1989 - "Surgical management of retinal traction caused by toxocariasis." 01/01/2008 - "Toxocariasis, also caused by a parasite, is second in importance, giving rise to choroidal granulomas and retinal tractions." 05/01/1990 - "Pars plana vitrectomy has been used in cases of ocular toxocariasis to remove vitreous opacities due to chronic inflammation and to relieve vitreo-retinal traction causing macular distortion and retinal detachment. " Order ALL the reference details at left...
3.	Aftercare (After-Treatment) 06/01/2008 - "In about 40% of the children whose households were not contaminated, a decrease in the antibody level was observed 2 years after treatment for toxocariasis, while there was no such decline in those living in contaminated places. " 01/01/1992 - "A quarter of patients with covert toxocariasis have no eosinophilia and, although symptoms regress after treatment, they may persist for months or years. " 01/01/2006 - "A serological follow-up study was carried out on 27 children (1-12 years old) with visceral and/or ocular toxocariasis, after treatment with thiabendazole. " 01/01/1999 - "One month after treatment eosinophilia decreased to 2.590 x mm3 and ELISA IgG for toxocariasis descended to 1:128. " Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 11/01/1994 - "A biometrical view on chemotherapy of toxocariasis." 07/01/2006 - "Toxocariasis was diagnosed in 3 out of 22 children (14%) treated in our center with high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT). " 07/01/2006 - "The authors conclude that toxocariasis should be taken into consideration in the differential diagnosis of eosinophilia in children undergoing high-dose chemotherapy and HSCT, especially if they are coming from rural areas." 01/01/2006 - "A serological follow-up of toxocariasis patients after chemotherapy based on the detection of IgG, IgA, and IgE antibodies by enzyme-linked immunosorbent assay." Order ALL the reference details at left...
5.	Light Coagulation 12/01/1995 - "Treatment of ocular toxocariasis can include a combination of cryopexy and photocoagulation, with vitrectomy surgery utilized in the more serious cases." 05/01/1987 - "[A case of ocular toxocariasis treated by xenon photocoagulation]" Order ALL the reference details at left...

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