Tooth Resorption

Resorption of calcified dental tissue, involving demineralization due to reversal of the cation exchange and lacunar resorption by osteoclasts. There are two types: external (as a result of tooth pathology) and internal (apparently initiated by a peculiar inflammatory hyperplasia of the pulp). (From Jablonski, Dictionary of Dentistry, 1992, p676)

Also Known As:

Networked: 45 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Periodontal Diseases (Periodontal Disease)
2.	Ankylosis
3.	Infections
4.	Hypercementosis
5.	Peri-Implantitis

Experts

1.	Reiter, Alexander M: 3 articles (11/2014 - 07/2005)
2.	Harvey, Colin E: 2 articles (01/2009 - 06/2008)
3.	Lewis, John R: 2 articles (06/2008 - 07/2005)
4.	Okuda, Ayako: 2 articles (06/2008 - 07/2005)
5.	Campos, Marcio José da Silva: 1 article (04/2022)
6.	Mota Júnior, Sergio Luiz: 1 article (04/2022)
7.	Pinheiro, Isabela Sales: 1 article (04/2022)
8.	Reis, Luisa Gatti: 1 article (04/2022)
9.	Vitral, Robert Willer Farinazzo: 1 article (04/2022)
10.	Bereznowski, Andrzej: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tooth Resorption:

1.	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/01/2009 - "In addition, 10 cats with radiographic evidence of pre-existing tooth resorption (14 affected teeth) were treated with vehicle or 3.0 mg/kg alendronate per os once weekly for 22-weeks and, then, 9.0 mg/kg per os twice weekly for 27-weeks in a random, masked study. " 01/01/2009 - "Alendronate binds to tooth root surfaces and inhibits progression of feline tooth resorption: a pilot proof-of-concept study."
2.	Triamcinolone (Aristocort)FDA Link 07/01/1989 - "Recent studies have shown that application of a triamcinolone-containing medicament to the dental pulp cavity inhibits dentinoclast-mediated tooth resorption in vivo and in vitro. "
3.	Vitamin DFDA LinkGeneric 07/01/2005 - "Chronic excess dietary vitamin D may be the long-sought cause of multiple tooth resorption in domestic cats. " 02/01/2010 - "However, increased expression of VDR protein, and the relative gene expression levels of 1alpha-hydroxylase and the VDR-target gene, 24-hydroxylase, indicated the involvement of an active vitamin D signalling in the pathophysiology of tooth resorption in cats." 02/01/2010 - "Here, we investigated the expression of VDR, MSX2, and RANKL proteins, and the activity of the VDR-mediated signalling pathway (using the quantitative polymerase chain reaction on VDR target genes), in tooth resorption, and measured the serum levels of vitamin D metabolites in cats. " 02/01/2010 - "Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats."
4.	Messenger RNA (mRNA)IBA 11/01/2011 - "Changes in the expression of RANKL mRNA and the RANKL/OPG mRNA ratio are accompanied by a parallel alteration in the number of odontoclasts and tooth resorption, suggesting crucial involvement of RANKL and OPG in tooth resorption." 08/01/2002 - "The results also suggest that OPG and RANKL mRNA play a role in mediating inflammatory responses in gingival cells, and that OPG has an inhibiting effect on tooth resorption."
5.	NestinIBA 02/01/2021 - "The early neural progenitor markers nestin and Dlx2 were detected in most serum-free cultured dental pulp stem cells, regardless of the tooth resorption stage from which they were harvested. "
6.	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/03/2020 - "Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption."
7.	Calcitriol Receptors (Calcitriol Receptor)IBA 02/01/2010 - "Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats."
8.	NF-kappa B (NF-kB)IBA 03/16/2023 - "Here, we investigated the influence of SR on orthodontic tooth movement and tooth resorption in Sprague-Dawley rats and the relationship between the nuclear factor-kappa B (NF-κB) pathway, autophagy, and osteoclastogenesis after the administration of SR in vitro and in vivo. "
9.	CytokinesIBA 01/01/2019 - "Some cytokines differed between groups between day 0 and day 6 and were associated with the presence of tooth resorption and number of missing tooth and tooth fractures. "
10.	Interleukin-6 (Interleukin 6)IBA 04/01/2012 - "In conclusion, we propose that TR(+) PBMCs when cultured on bone are sensitive to 1,25(OH)(2)D, whereas the differentiation of TR(-) PMBCs on bone seem more sensitive to IL-6, suggesting that osteoclast precursors from cats with and without tooth resorption respond differently to osteoclast stimulating factors." 04/01/2012 - "Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25-dihydroxyvitamin D and interleukin-6." 04/01/2012 - "We studied the effect of 1,25-dihydroxycholecalciferol (1,25(OH)(2)D), and interleukin-6 (IL-6), on the formation and activity of feline osteoclasts, using peripheral blood mononuclear cells (PBMCs) from cats with and without tooth resorption (TR(+) and TR(-)) as a source of osteoclast precursors. "

Therapies and Procedures

1.	Transplantation 04/01/1987 - "Tooth resorption in the two-stage transplantation technique: a case report." 07/01/1983 - "Tooth resorption in the two-stage transplantation technique--a case report."
2.	Tooth Extraction (Tooth Extractions) 12/01/2023 - "This tooth was not only partially transposed, but it also had ankylosis, external and internal tooth resorption, which indicated the need for tooth extraction. " 11/01/2014 - "Tooth extraction is predominantly performed in cats with tooth resorption, chronic gingivostomatitis and periodontal disease. "
3.	Therapeutics 07/01/2021 - "In case of infection-induced tooth resorption, endodontic therapy needs to be carried out to decrease bacterial load within the pulp space and facilitate repair of resorbed tooth structure. " 03/01/2007 - "Infection induced tooth resorptions require the removal of the invading micro-organisms by endodontic therapy including intra-canal medication which can also facilitate repair of the resorbed tooth structure. "
4.	Replantation 01/01/2014 - "MTA may be a viable clinical option for filling teeth submitted to delayed replantation, and is an acceptable option for treating replanted permanent teeth in order to prevent tooth resorption, particularly when dressing changes are not possible. " 03/01/2021 - "Denosumab 60 mg/mL reducted ankylosis (p < 0.0001), replacement resorption (p < 0.0001), and tooth resorption, 60 days after replantation, compared to untreated replanted teeth (p < 0.005). "
5.	Orthodontic Extrusion 06/01/2008 - "Significant association between tooth extrusion and tooth resorption in domestic cats."