Tooth Abnormalities

Congenital absence of or defects in structures of the teeth.

Also Known As:

Abnormalities, Teeth; Abnormalities, Tooth; Teeth Abnormalities; Abnormality, Teeth; Abnormality, Tooth; Odontomes; Teeth Abnormality; Tooth Abnormality; Odontome

Networked: 33 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Stomatognathic Diseases: 705
- Tooth Diseases: 33
  - Tooth Abnormalities: 33
- Stomatognathic System Abnormalities
  - Tooth Abnormalities: 33
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Stomatognathic System Abnormalities
    - Tooth Abnormalities: 33

Related Diseases

1.	Lipomatosis
2.	Congenital Abnormalities (Deformity)
3.	Brachydactyly
4.	Chloracne
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Experts

1.	Olczak-Kowalczyk, Dorota: 2 articles (08/2022 - 01/2016)
2.	Gozdowski, Dariusz: 1 article (08/2022)
3.	Pańczyk-Tomaszewska, Małgorzata: 1 article (08/2022)
4.	Piekoszewska-Ziętek, Paula: 1 article (08/2022)
5.	Biberoğlu, Gürsel: 1 article (07/2021)
6.	Buyan, Necla: 1 article (07/2021)
7.	Demir, Ercan: 1 article (07/2021)
8.	Ergin, Filiz Başak Cengiz: 1 article (07/2021)
9.	Ezgü, Fatih Süheyl: 1 article (07/2021)
10.	Okur, İlyas: 1 article (07/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tooth Abnormalities:

1.	Fenofibrate (CiL)FDA LinkGeneric 02/01/2013 - "Tooth abnormalities including accelerated tooth formation or eruption, macrodontia, and root hypoplasia are common in CIL-F." 02/01/2013 - "In total, 21 cases with tooth abnormalities in CIL-F were retrieved for analysis. " 02/01/2013 - "Tooth abnormalities in CIL-F documented in the English literature are also reviewed. " 02/01/2013 - "The aim of this study was to present a literature review and case series report of tooth abnormalities in congenital infiltrating lipomatosis of the face (CIL-F). "
2.	Antineoplastic Agents (Antineoplastics)IBA 01/01/2016 - "Antineoplastic chemotherapy and congenital tooth abnormalities in children and adolescents." 01/01/2016 - "Study objective is to assess the correlation between tooth abnormalities, early complications of multidrug chemotherapy, and chemotherapeutics used in different antineoplastic therapies in children and adolescents. "
3.	Phosphates (Orthophosphate)IBA 01/01/2015 - "Clinical features include skeletal deformities, teeth abnormalities, hearing impairments and variable serum phosphate level in patients of this family. " 12/01/2002 - "These findings suggest that while the Hyp bone and teeth abnormalities partially correct after PHEX gene transfer, additional factors and/or sites of PHEX expression are likely critical for the elaboration of the appropriate molecular signals that alter renal phosphate handling and vitamin D metabolism in this disorder." 01/01/2001 - "Characteristic phenotypic features (degree of leg deformities, growth failure, tooth abnormalities, tubular reabsorption of phosphate, serum phosphate and 1,25-dihydroxyvitamin D3 concentrations, head length and hearing defect in some cases) were assessed in relation to the type and localisation of 29 different PHEX gene mutations. "
4.	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 07/01/2021 - "Considering the wide spectrum of clinical signs and symptoms, HPP should be among the differential lists of bone, muscle, and tooth abnormalities at any age." 09/01/2012 - "Administration of mineral-targeting TNAP from birth increased survival and prevented the seizures, rickets, as well as all the tooth abnormalities, including dentin, acellular cementum, and enamel defects in this model of severe HPP. "
5.	Growth Differentiation Factor 5IBA 06/01/2004 - "Angel shaped phalangeal dysplasia, hip dysplasia, and positional teeth abnormalities are part of the brachydactyly C spectrum associated with CDMP-1 mutations."
6.	Connexin 43 (Connexin43)IBA 06/01/2010 - "To assess the role of Cx43 in tooth development we employ a mouse model of ODDD that harbors a G60S Cx43 mutant, Gja1(Jrt)/+, and appears to exhibit tooth abnormalities that mimic the human disease. "
7.	Biomarkers (Surrogate Marker)IBA 05/01/2013 - "Diagnosis occurs most frequently during adolescence and teeth abnormalities were the most frequent clinical marker of XLHED." 05/01/2013 - "Teeth abnormalities occurred in 79% of all cases and 52% of molecularly-confirmed cases as a primary clinical marker. "
8.	Vitamin D FDA LinkGeneric 12/01/2002 - "These findings suggest that while the Hyp bone and teeth abnormalities partially correct after PHEX gene transfer, additional factors and/or sites of PHEX expression are likely critical for the elaboration of the appropriate molecular signals that alter renal phosphate handling and vitamin D metabolism in this disorder."
9.	SolutionsIBA 10/01/2010 - "If, not long time ago, the simple prosthetic rehabilitation of an edentulous patient--with or without additional maxillary teeth abnormalities--was the only therapeutic solution, presently, the pre-prosthetic orthodontic treatment enabling the dental restoration treatment meets the basic requirements of any dental treatment, i.e. "
10.	SmokeIBA 05/01/2008 - "These included prenatal high-level methylmercury (CH(3)Hg) exposure (delayed developmental milestones and cognitive, motor, auditory, and visual deficits), high-level prenatal exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related toxicants (neonatal tooth abnormalities, cognitive and motor deficits), maternal active smoking (delayed conception, preterm birth, fetal growth deficit [FGD] and sudden infant death syndrome [SIDS]) and prenatal environmental tobacco smoke (ETS) exposure (preterm birth), low-level childhood lead exposure (cognitive deficits and renal tubular damage), high-level childhood CH(3)Hg exposure (visual deficits), high-level childhood exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (chloracne), childhood ETS exposure (SIDS, new-onset asthma, increased asthma severity, lung and middle ear infections, and adult breast and lung cancer), childhood exposure to biomass smoke (lung infections), and childhood exposure to outdoor air pollutants (increased asthma severity). "

Therapies and Procedures

1.	Therapeutics 11/15/2023 - "No correlation was observed between the treatment duration of an intensive therapy, the entire therapy, and the number of tooth abnormalities. " 01/01/2016 - "Study objective is to assess the correlation between tooth abnormalities, early complications of multidrug chemotherapy, and chemotherapeutics used in different antineoplastic therapies in children and adolescents. "
2.	Lasers (Laser) 03/01/2019 - "The aim of this study was to design a simple, effective, and non-invasive technique, employing a novel laser wavelength to classify and differentiate between various tooth abnormalities in-vitro, by estimating wavelengths, showing distinctive appearance for each tooth class. "
3.	Drug Therapy (Chemotherapy) 01/01/2016 - "Antineoplastic chemotherapy and congenital tooth abnormalities in children and adolescents." 01/01/2016 - "Study objective is to assess the correlation between tooth abnormalities, early complications of multidrug chemotherapy, and chemotherapeutics used in different antineoplastic therapies in children and adolescents. "
4.	Local Anesthesia 05/01/2017 - "The surgical extraction of odontome was performed under local anesthesia to allow eruption of underlying premolar tooth. " 01/01/2017 - "Under local anesthesia, the odontome was excised; the inverted tooth was swung and repositioned. "
5.	Chemoradiotherapy 12/01/2007 - "This clinical report describes the prosthodontic management of a young patient who received chemoradiotherapy for neuroblastoma and subsequently developed tooth abnormalities. "