|1.||Friedman, Mendel: 4 articles (04/2015 - 12/2007)|
|2.||Mustafa, Mohd Rais: 3 articles (11/2013 - 01/2011)|
|3.||Wong, Pooi-Fong: 3 articles (11/2013 - 01/2011)|
|4.||Lee, Sui-Ting: 3 articles (11/2013 - 01/2011)|
|5.||Du, Zhiyun: 2 articles (06/2015 - 01/2015)|
|6.||He, Yan: 2 articles (06/2015 - 01/2015)|
|7.||Li, Dongli: 2 articles (06/2015 - 01/2015)|
|8.||Zheng, Xi: 2 articles (06/2015 - 01/2015)|
|9.||Goodin, Susan: 2 articles (06/2015 - 01/2015)|
|10.||Huang, Huarong: 2 articles (06/2015 - 01/2015)|
|1.||Prostatic Neoplasms (Prostate Cancer)
01/01/2011 - "These results suggest that α-tomatine may be beneficial for protection against prostate cancer development and progression."
01/01/2013 - "Our study provides first evidence for in vivo antitumor efficacy of α-tomatine against the human androgen-independent prostate cancer. "
01/01/2013 - "The potential usefulness of α-tomatine in prostate cancer prevention and therapy requires further investigation."
01/01/2011 - "α-tomatine induces apoptosis and inhibits NF-κB activation on prostate cancer cells. "
01/01/2011 - "Treatment of highly aggressive human prostate cancer PC-3 cells with α-tomatine resulted in a concentration-dependent inhibition of cell growth with a half-maximal efficient concentration (EC(50)) value of 1.67±0.3 µM. "
05/01/2013 - "α-Tomatine has numerous potential health benefits including the ability to inhibit cancer cell growth in in vitro studies. "
01/01/2013 - "Analysis of tumor material indicates that the tumor suppressing effects of α-tomatine were accompanied by increased apoptosis and lower proliferation of tumor cells as well as reduced nuclear translocation of the p50 and p65 components of NF-κB. "
01/01/2013 - "Our data indicate that intraperitoneal administration of α-tomatine significantly attenuates the growth of PC-3 cell tumors grown at both sites. "
01/01/2013 - "We also evaluated the antitumor activity of α-tomatine against PC-3 cell tumors grown subcutaneously and orthotopically in mice. "
01/01/2013 - "However, the precise mechanism by which α-tomatine suppresses NF-κB nuclear translocation is yet to be elucidated and the anti-tumor activity of this agent in vivo has not been examined. "
01/01/2010 - "Further characterization of tomatine as an adjuvant in malaria vaccine development is indicated."
01/01/2010 - "Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+ T cell release of IFN-gamma."
07/20/2001 - "These findings merit further work to optimise the use of tomatine as an adjuvant in malaria vaccine development."
06/23/2004 - "Here we describe Tomatine, a glycoalkaloid based adjuvant, capable of stimulating potent antigen-specific humoral and cellular immune responses that contribute to protection against malaria, Francisella tularensis and regression of experimental tumors. "
01/01/2010 - "The glycoalkaloid tomatine, derived from the wild tomato, can act as a powerful adjuvant to elicit an antigen-specific cell-mediated immune response to the circumsporozoite (CS) protein, a major pre-erythrocytic stage malaria vaccine candidate antigen. "
12/01/2013 - "In the present study, we focused on the cytotoxic effect of α-tomatine in the MCF-7 human breast adenocarcinoma cell line, its mechanism of action, biotransformation and stability in the culture medium. "
01/01/2011 - "This study investigates the chemopreventive potential of α-tomatine on androgen-independent human prostatic adenocarcinoma PC-3 cells. "
05/01/2013 - "Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by α-tomatine through activating PKCα/ERK/NF-κB-dependent MMP-2/MMP-9 expressions."
12/01/2013 - "The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction."
06/01/2014 - "Protective effect of tomatine against hydrogen peroxide-induced neurotoxicity in neuroblastoma (SH-SY5Y) cells."
03/01/2014 - "The aim of this study was to investigate for the first time whether both extracts from tomato plant (Lycopersicon esculentum Mill.) leaves and their isolated steroidal alkaloids (tomatine and tomatidine) afford neuroprotective effect against glutamate-induced toxicity in SH-SY5Y neuroblastoma cells and to elucidate the mechanisms underlying this protection. "
01/01/1991 - "The effects of the potato glycoalkaloids alpha-chaconine, alpha-solanine and tomatine on the intracellular free Ca(2+) concentration were studied in undifferentiated mouse neuroblastoma x rat glioma hybrid NG 108-15 cells, mouse-skin fibroblastoma L-929 cells and mouse Balb/3T3 cells by using the Ca(2+)-sensitive fluorescent dye Fura-2. "
|5.||Glutamic Acid (Glutamate)
|7.||Apolipoproteins E (ApoE)
|1.||Heterologous Transplantation (Xenotransplantation)