Tobacco Use Disorder (Nicotine Dependence)

Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.

Also Known As:

Nicotine Dependence; Dependence, Nicotine; Tobacco-Use Disorder; Addiction, Nicotine; Dependence, Tobacco; Disorder, Nicotine Use; Disorder, Tobacco Use; Disorder, Tobacco-Use; Nicotine Addictions; Nicotine Use Disorders; Tobacco Use Disorders; Nicotine Addiction; Nicotine Use Disorder; Tobacco Dependence

Networked: 3728 relevant articles (205 outcomes, 632 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Substance-Related Disorders (Drug Abuse)
2.	Alcoholism (Alcohol Abuse)
3.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
4.	Schizophrenia (Dementia Praecox)
5.	Mental Disorders (Mental Disorder)

Experts

1.	Tyndale, Rachel F: 55 articles (01/2021 - 02/2002)
2.	Lerman, Caryn: 46 articles (01/2020 - 09/2003)
3.	Benowitz, Neal L: 40 articles (01/2022 - 11/2003)
4.	Li, Ming D: 40 articles (01/2020 - 05/2005)
5.	Le Foll, Bernard: 34 articles (01/2021 - 04/2005)
6.	Ebbert, Jon O: 31 articles (01/2018 - 08/2002)
7.	Bierut, Laura J: 29 articles (11/2021 - 01/2006)
8.	Ma, Jennie Z: 27 articles (01/2015 - 05/2005)
9.	Payne, Thomas J: 26 articles (01/2017 - 10/2003)
10.	Saccone, Nancy L: 25 articles (11/2021 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tobacco Use Disorder:

1.	Nicotine FDA Link 03/01/2018 - "Adherence to transdermal nicotine patches, one of the most popular and effective treatment for nicotine dependence, remains very low and is a strong predictor of cessation rates. " 01/01/2009 - "The Hooked on Nicotine Checklist (HONC) test proved to be the most useful for the group of teenagers whereas for adults the CAGE questionnaire, the Four C test, the Fagerström Test for Nicotine Dependence (FTND) and Heaviness of Smoking Index (HIS) gave the best results. " 03/01/1996 - "Nicotine transdermal patches were most effective for smokers with moderate nicotine dependence and for younger smokers. " 10/01/2019 - "Cured tobacco products with a significantly reduced nicotine content helps people to overcome their nicotine addiction. " 01/01/2019 - "Sexual minorities who experienced high levels of past-year sexual orientation discrimination had significantly greater probability of cigarette smoking, any tobacco/nicotine use and DSM-5 tobacco use disorder."
2.	Bupropion (Wellbutrin)FDA LinkGeneric 10/01/2023 - "We identified CUD patients with co-occurring nicotine dependence and observed that patients prescribed bupropion displayed a higher rate of CUD remission compared to matched individuals prescribed other drugs for nicotine dependence: 1.38 (95% CI: 1.11-1.71). " 02/01/2004 - "Bupropion SR has been shown to be effective for the treatment of nicotine dependence in adults. " 01/01/2002 - "Bupropion SR has also been found to be a useful treatment of tobacco dependence in various special populations of smokers who often experience difficulty in overcoming tobacco addiction. " 01/01/2004 - "The aim of the study was a one year evaluation of the efficacy of bupropion SR supported by an educational program in the treatment of nicotine dependence and analysis of the reasons of relapses. " 10/01/2023 - "Our findings suggest that bupropion might be considered a treatment for improving CUD remission in patients with CUD and co-occurring depression or nicotine dependence."
3.	Varenicline (Chantix)FDA Link 05/01/2016 - "Varenicline, a nicotinic partial agonist, is the most effective treatment for tobacco use disorder. " 05/01/2006 - "Phase II and III trials have yielded promising results suggesting that varenicline could be an important advance in the treatment of nicotine dependence." 10/01/2012 - "Varenicline represents a major advance in the treatment of nicotine addiction and has been shown to be safe and effective to promote abstinence. " 09/01/2009 - "Varenicline, an alpha4beta2-nicotinic partial agonist, is effective for nicotine dependence. " 01/01/2018 - "Identifying predictors of treatment outcome for nicotine use disorders (NUDs) may help improve efficacy of established treatments, like varenicline. "
4.	SmokeIBA 09/01/2011 - "Further studies and interventions should explore the efficacy of tobacco treatment interventions in a larger segment of the population, notably in the subpopulations of people with nicotine dependence who smoke fewer than 10 cigarettes per day or who have comorbid depression." 01/01/1992 - "Demographic characteristics (age, sex, site of employment) and smoking variables (number of years smoked, pretreatment number of cigarettes smoked per day, and nicotine dependence) failed to predict compliance, but complaint participants reported significantly greater confidence at their ability to not smoke in various challenging situations as measured by the Smoking Self Efficacy Questionnaire. " 06/01/2005 - "Smokers treated for nicotine dependence who stop smoking for a year report more improvement in-quality-of-life compared with those who continue to smoke." 01/01/2021 - "Public health interventions that have proved particularly effective in reducing smoking prevalence (tobacco tax increases, smoke-free environment legislation, antismoking mass media campaigns) are expected to also contribute to a decline in population-level nicotine dependence." 01/01/2018 - "The main findings suggest a comprehensive smoke-free hospital environment can strengthen the tobacco-free workplace culture within a hospital setting among HCPs where support for tobacco reduction is amplified, patient care and interactions regarding tobacco dependence are improved, and staff morale is enhanced. "
5.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 06/05/2009 - "Our analysis reveals significant evidence for at least four distinct loci in the nicotinic receptor subunit genes that each influence the transition from smoking to nicotine dependence and may inform the development of improved smoking cessation treatments and prevention initiatives." 01/01/2020 - "Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the α5, α3, and β4 nicotinic acetylcholine receptor (nAChR) subunits, to nicotine addiction. " 10/22/2018 - "Meta-analysis of large-scale human genome-wide association studies (GWASs) identified a frequent non-synonymous SNP in the gene coding for the α5 subunit of nicotinic acetylcholine receptors (α5SNP), which significantly increases the risk for tobacco dependence and delays smoking cessation. " 01/01/2018 - "This study evaluated the relationship between CHRNA5, a nicotinic receptor subunit gene, and smoking in predicting IBD-related surgery as well as the relationship between CHRNA5 and nicotine dependence. " 01/01/2017 - "Although numerous studies have revealed significant associations between variants in the nicotinic acetylcholine receptors (nAChR) subunits and nicotine dependence (ND), only few studies were performed in Chinese subjects. "
6.	Dopamine (Intropin)FDA LinkGeneric 01/01/2018 - "This study adds to the growing literature about cigarette versus nondrug reward processing in nicotine dependence and the role of dopamine in cigarette-seeking behavior. " 06/01/2014 - "This paper provides a review for recent advance in studies on dopamine system related genetic polymorphisms associated with nicotine dependence. " 06/01/2014 - "[Advance in studies on dopamine system related genetic polymorphisms associated with nicotine dependence]." 08/01/2011 - "Several studies have provided evidence for associations of polymorphisms located in and near dopamine-related genes and nicotine dependence and other smoking-related phenotypes, including pharmacogenetic interactions. " 09/30/2010 - "The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. "
7.	Opioid Analgesics (Opioids)IBA 01/01/2022 - "This qualitative study used four focus groups informed by the Promoting Action on Research Implementation in Health Services framework to identify barriers and facilitators to receiving opioid, alcohol, and tobacco use disorder care in HIV clinics. " 06/01/2018 - "As such, the present study aims to explore the association between nicotine dependence and physical health among participants of the Study to Assess Longer-Term Opioid Medication Effectiveness (SALOME) at baseline and six-months. " 03/17/2023 - "SB patients also had increased rates of nicotine dependence (OR 1.546, 95% CI 1.22-1.959) but not of alcohol or opioid disorders. " 02/10/2023 - "LCA was conducted using diagnoses and diagnostic criteria of alcohol, cannabis, opioid, and tobacco use disorders. " 01/01/2023 - "Findings are consistent with previous research on opioid use behavior in young adulthood and suggest that nicotine dependence and CUD criteria among urban young people predict onset of OUD and OUD criteria in young adulthood."
8.	Cocaine (Cocaine HCl)IBA 11/30/2016 - "To our knowledge, this is the first study to evaluate the effects of a multi-week exercise program in individuals with concurrent cocaine and tobacco-use disorder. " 11/01/2008 - "Furthermore, three studies examining rTMS as a potential treatment in cocaine and nicotine addiction report decreases in the level of cravings and in the number of cigarettes smoked following rTMS administration to the dorsal lateral prefrontal cortex. " 01/01/2023 - "Diagnosis of anxiety, depression, nicotine use disorder, and stimulant/cocaine use disorder, and insurance and race can influence retention in MT. " 01/01/2023 - "Factors positively associated with retention were diagnosis of anxiety, depression, and nicotine use disorder, White race, private insurance, and Medicaid insurance; however, stimulant/cocaine use disorder was negatively associated (one-year follow-up, p ≤ .028; two-year follow-up, p ≤ .017). " 10/16/2022 - "Results: Young CUD+ had higher prevalence of HC (0.7%, n = 4675) than CUD- (0.5%, n = 92,755), with higher odds when adjusted for patient/hospital-characteristics, comorbidities, alcohol and tobacco use disorder, cocaine and stimulant use (aOR 1.15, 95%CI:1.06−1.24, p = 0.001). "
9.	Biomarkers (Surrogate Marker)IBA 01/01/2017 - "However, the remission from tobacco dependence group exhibited no significant changes in any of the biomarkers examined. " 04/01/2009 - "Resting-state dACC-striatum functional connectivity may serve as a circuit-level biomarker for nicotine addiction, and the development of new therapeutic agents aiming to enhance the dACC-striatum functional pathways may be effective for nicotine addiction treatment." 11/05/2021 - "Predicted biomarker associations helped define genetically influenced components of nicotine dependence. " 10/01/2023 - "In the present study, we identified biochemical and genetic biomarkers of nicotine dependence detected by the Fagerström Test for Nicotine Dependence (FTDN) in Mexican smokers. " 01/01/2017 - "While extensive efforts have been made to study the pathophysiology of nicotine addiction, more limited works were developed to find imaging biomarkers. "
10.	VaccinesIBA 01/01/2013 - "We reviewed the current status of vaccines against nicotine addiction that are undergoing clinical trials or are in preclinical development. " 09/01/2019 - "The four elements of the Tobacco Control Vaccine are access to treatment for tobacco dependence, smoke-free policies, increased tobacco taxes, and media campaigns. " 11/17/2015 - "Therapeutic vaccines for nicotine addiction show pre-clinical efficacy. " 01/01/2014 - "Thus, there is undoubtedly an urgent need for developing novel vaccines against nicotine addiction. " 08/01/2013 - "[Recent progress in vaccines against nicotine addiction]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/2015 - "While pharmacotherapies are recommended as a first-line treatment for nicotine dependence, the few studies that have investigated their effectiveness in this population have shown dramatically poorer outcomes compared to the general population. " 06/01/2013 - "Recommendations for future research include examining underlying factors that contribute to persistent smoking and barriers to abstinence, identifying ways to increase motivation for quit attempts, increasing the number of multicentered 2-arm tobacco dependence treatment trials, and using highly efficacious first-line pharmacotherapy in tobacco dependence treatment intervention studies. " 01/01/2014 - "Despite the proven efficacy of current pharmacotherapies for tobacco dependence, relapse rates continue to be high, indicating that novel medications are needed. " 04/16/2010 - "Seven first-line pharmacotherapies are currently available and recommended by the United States Public Health Service (USPHS) clinical practice guideline for treating tobacco dependence, all of which have been proven to be effective for increasing tobacco abstinence rates when used as monotherapy. " 01/01/2008 - "The training of health professions in the area of nicotine addiction must also be improved, so that they may better assist smokers in their quit attempts and advise patients on, and prescribe, effective smoking cessation pharmacotherapies."
2.	Nicotine Replacement Therapy 12/01/2005 - "Nicotine replacement therapies (NRT) are an effective treatment for tobacco dependence, yet most smokers do not quit or remain abstinent. " 01/01/2008 - "Nicotine replacement therapies are effective in the treatment of tobacco dependence and withdrawal, but do not meet the needs of all tobacco users. " 01/01/2001 - "Currently available nicotine replacement therapy (NRT) medications provide effective treatment for tobacco dependence, typically doubling success rates compared with placebo. " 01/01/2019 - "Pharmacological treatments for tobacco dependence, such as nicotine replacement therapy (NRT), have been shown to be safe and effective interventions for smoking cessation. " 02/23/2015 - "Pharmacological treatments for tobacco dependence, such as nicotine replacement therapy (NRT), have been shown to be safe and effective interventions for smoking cessation. "
3.	Therapeutics 07/01/2015 - "Therapies aimed at enhancing this reward-based deficit may be beneficial in the treatment of both nicotine dependence and MDD. " 01/01/2019 - "Smoking cessation therapeutics are only marginally effective, and by identifying cellular/receptor mechanisms of nicotine dependence, our results take a step toward improved therapeutic approaches for this disorder." 07/01/2006 - "Efficacious therapy for tobacco dependence exists, and nurses have been shown to be effective tobacco cessation interventionists. " 11/28/2022 - "Results of the present study suggest that VCO has the potential to be a safe and effective adjunct therapy for the management of nicotine dependence." 01/25/2023 - "We will conduct a randomized controlled study in treatment-seeking individuals with tobacco use disorder applying either chess-based cognitive remediation training (N = 30) or implicit computer-based habit-modifying training (N = 30) as add on therapy compared to the standard smoking cessation group therapy (N = 30) only. "
4.	Tobacco Use Cessation Devices 01/01/2005 - "The effect of active NRT treatment did not differ significantly by smoking rate or nicotine dependence, with the exception that the nicotine patch was significantly more effective than placebo in highly dependent smokers. " 01/01/2020 - "The 4 mg nicotine lozenge provided a directionally significant improvement in smoking cessation rates compared with placebo in Chinese adult smokers with high nicotine dependence for the primary endpoint. " 08/01/2005 - "These effects have implications for the safety and efficacy of marihuana smokers who are self-medicating with the nicotine transdermal patch to manage their tobacco dependence." 01/01/2019 - "This trial aims to explore whether gradually transitioning to VLNC cigarettes plus nicotine patch or reducing CPD plus nicotine patch is more effective at decreasing nicotine dependence. " 12/01/2012 - "Twenty-four NC smokers and 20 smokers with SZ matched on nicotine addiction severity participated in a resting state fMRI study and were scanned during two separate sessions while receiving a placebo or nicotine patch, in a randomized, cross-over design. "
5.	Secondary Prevention 01/01/2011 - "It is concluded that the results of this pilot study are encouraging and suggest that NAC might be a promising new treatment option for relapse prevention in nicotine dependence." 12/01/2007 - "Finally, we point out the need for further investigations of the moderating role of individual differences in response to NA in the maintenance of nicotine dependence, and controlled randomized trials testing the efficacy of acceptance-based interventions in facilitating smoking cessation and relapse prevention." 01/01/2002 - "Consequently, active immunization may provide long-term protection against initiation of tobacco dependence, an effect that may prove particularly advantageous in relapse prevention." 01/01/2023 - "Secondary prevention must include treating tobacco dependence." 10/01/2018 - "In 2014, the Medical University of South Carolina (MUSC) implemented a Tobacco Dependence Treatment Service (TDTS) consistent with the Joint Commission (JC) standards recommending that hospitals screen patients for smoking, provide cessation support, and follow-up contact for relapse prevention within 1 month of discharge. "