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Tiletamine

Proposed anesthetic with possible anticonvulsant and sedative properties.
Also Known As:
2-(Ethylamino)-2-(2-thienyl)cyclohexanone; CI-634; Tiletamine Hydrochloride; CI 634; CI634; Hydrochloride, Tiletamine; Cyclohexanone, 2-(ethylamino)-2-(2-thienyl)-
Networked: 17 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Owen, Patricia A: 1 article (01/2014)
2. Nelson, O Lynne: 1 article (01/2014)
3. Robbins, Charles T: 1 article (01/2014)
4. Farley, Sean D: 1 article (01/2014)
5. Madel, Michael J: 1 article (01/2014)
6. Erlenbach, Joy A: 1 article (01/2014)
7. Teisberg, Justin E: 1 article (01/2014)
8. Hilderbrand, Grant V: 1 article (01/2014)
9. Lee, Jae Y: 1 article (03/2012)
10. Kim, Myung C: 1 article (03/2012)

Related Diseases

1. Seizures (Seizure)
10/04/1988 - "At higher doses, however, tiletamine induced convulsions by itself. "
10/01/1999 - "Tiletamine is a disassociative anesthetic similar to ketamine and phencyclidine, and zolazepam is a diazepine derivative tranquilizer used to minimize the muscle hypertonicity and seizures associated with tiletamine. "
10/04/1988 - "Tiletamine-induced convulsions were antagonized by the broad spectrum excitatory amino acid antagonist, gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS), and were potentiated by the competitive NMDA antagonist, 2-amino-7-phosphonohepatanoate (AP7). "
10/04/1988 - "Intracerebroventricular (i.c.v.) injection of tiletamine, 0.001 mumol, a presumed non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, protected mice from convulsions induced by NMDA and quinolinate, but not from those induced by excitatory amino acids interacting preferentially with non-NMDA receptors. "
07/18/1989 - "The ED50 values for protection against sound-induced clonic seizures 15 min following the intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration are: MK-801, ED50 = 0.5 nmol (i.c.v.); 0.14 mumol/kg (i.p.); phencyclidine, ED50 = 14 nmol (i.c.v.); 1.9 mumol/kg (i.p.); dextrorphan, ED50 = 35 nmol (i.c.v.); 18.5 mumol/kg (i.p.); tiletamine, ED50 = 40 nmol (i.c.v.); 5.6 mumol/kg (i.p.); SKF-10047, ED50 = 50 nmol (i.c.v.); 23.5 mumol/kg (i.p.); dextromethorphan, ED50 = 70 nmol (i.c.v.); 28.0 mumol/kg (i.p.); ketamine, ED50 = 110 nmol (i.c.v.); 15.5 mumol/kg (i.p.). "
2. Anoxia (Hypoxia)
3. Body Weight (Weight, Body)
4. Bradycardia
5. Ataxia (Dyssynergia)

Related Drugs and Biologics

1. Ketamine
2. Phencyclidine (Angel Dust)
3. Dizocilpine Maleate (Dizocilpine)
4. Dextrorphan
5. Dextromethorphan (Levomethorphan)
6. SK&F 10047
7. Zolazepam
8. Medetomidine
9. Oxygen
10. Xylazine (Xylazin)

Related Therapies and Procedures

1. Anesthesia
2. Intramuscular Injections