Tibial Fractures (Fracture, Tibial)

Fractures of the TIBIA.

Also Known As:

Fracture, Tibial; Segond Fracture; Tillaux Fracture; Toddler's Fracture; Fracture, Segond; Fracture, Tillaux; Fracture, Toddler's; Fractures, Tibial; Tibial Fracture; Toddler Fracture; Toddlers Fracture

Networked: 1458 relevant articles (64 outcomes, 240 trials/studies)

Relationship Network

Disease Context: Research Results

Wounds and Injuries: 176426
- Bone Fractures: 3857
  - Tibial Fractures: 1458
    - Tibial Plateau Fractures: 424
    - 'corner fracture' type Spondylometaphyseal dysplasia: 1
- Leg Injuries: 75
  - Tibial Fractures: 1458
    - Tibial Plateau Fractures: 424
    - 'corner fracture' type Spondylometaphyseal dysplasia: 1

Related Diseases

1.	Infections
2.	Wounds and Injuries (Trauma)
3.	Fat Embolism
4.	Pain (Aches)
5.	Femoral Fractures (Femoral Fracture)

Experts

1.	Bhandari, Mohit: 14 articles (01/2021 - 10/2002)
2.	Tornetta, Paul: 9 articles (02/2021 - 10/2002)
3.	Sprague, Sheila: 8 articles (01/2021 - 10/2002)
4.	Schemitsch, Emil H: 7 articles (08/2020 - 10/2002)
5.	Silveira, Landulfo: 6 articles (06/2020 - 09/2010)
6.	Khan, Umraz: 6 articles (04/2020 - 10/2017)
7.	O'Toole, Robert V: 5 articles (01/2022 - 12/2016)
8.	Li, Yize: 5 articles (01/2022 - 05/2020)
9.	Qian, Yanning: 5 articles (01/2022 - 01/2016)
10.	Yu, Yonghao: 5 articles (01/2022 - 05/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tibial Fractures:

1.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2016 - "Are antibiotic nails effective in the treatment of infected tibial fractures?" 11/01/2022 - "Large multicentric randomized controlled trials and a long term follow up are advised to further explore the role of PLA coated antibiotic nails in open tibial fractures." 10/01/2022 - "Therefore, we conducted this prospective randomized study to compare the functional and radiological outcomes of primary ring fixator versus antibiotic coated nail in open diaphyseal tibial fractures. " 12/01/2020 - "Our study shows good radiological and functional outcomes with prophylactic antibiotic-coated nailing of open tibial fractures of Grades II and IIIA. " 01/01/2016 - "We reviewed and evaluated all published clinical trials claiming or cited elsewhere as being authoritative regarding the duration of prophylactic antibiotic use in open tibial fracture management. "
2.	Gentamicins (Gentamicin)FDA LinkGeneric 02/10/2021 - "If proven effective, local gentamicin would be a low-cost strategy to reduce complications and disability from open tibial fractures that could impact care in both high- and low-income countries. " 02/10/2021 - "The results of this study will inform the design and feasibility of a definitive trial to address the use of local gentamicin in open tibial fractures. " 06/01/2023 - "This pilot study is among the first to evaluate locally administered gentamicin in open tibial fractures. " 06/01/2023 - "A pilot, masked, randomized controlled trial to evaluate local gentamicin versus saline in open tibial fractures (pGO-Tibia)." 10/01/2011 - "In this prospective, non-randomized case series, we investigated the clinical, laboratory and radiological outcomes of 21 patients who underwent surgical treatment in closed or open tibial fractures, as well as revisions with the UTN PROtect gentamicin-coated intramedullary nail. "
3.	Cefazolin (Ancef)FDA LinkGeneric 03/01/1997 - "Delayed local treatment of rabbit tibial fractures with biodegradable cefazolin microspheres." 01/01/2018 - "Appropriate weight-based dosing of cefazolin for prophylaxis in high-grade open tibial fractures reduces the frequency of infection due to cefazolin-sensitive organisms. " 05/01/1993 - "Evaluation of biodegradable cefazolin sodium microspheres for the prevention of infection in rabbits with experimental open tibial fractures stabilized with internal fixation." 05/01/1993 - "Rabbits with experimental tibial fractures that were contaminated with Staphylococcus aureus were treated with local application of cefazolin microspheres, an equivalent local dose of free Ancef powder, or systemic Ancef therapy. " 03/01/1997 - "The objective of this study was to compare the efficacy of biodegradable, poly (DL-lactide-co-glycolide) cefazolin microspheres and free cefazolin powder in Staphylococcus aureus contaminated rabbit tibial fractures when treatment was delayed for 2 hours. "
4.	Methylprednisolone FDA LinkGeneric 03/01/2004 - "The efficacy of a minimum dose of methylprednisolone for the prevention of posttraumatic hypoxaemia and fat embolism syndrome (FES) was prospectively studied in 87 patients with isolated, closed or grade I open, femoral and tibial fractures. " 01/01/1987 - "Fifty-five adults who had sustained a tibial fracture, or a femoral fracture, or both, were subjected to a double-blind randomised study to determine the efficacy of methylprednisolone in treating the fat embolism syndrome. "
5.	MetalsIBA 09/30/2023 - "Conclusions: Metal plate exposure after distal tibial fractures have been treated with minimally invasive metal plate fusion and can be successfully treated with retrograde nasogastric artery flaps, and several surgical techniques are used during flap surgery." 11/01/2023 - "Stabilization of Tibial Fractures at Risk of Complications With the Bactiguard Intramedullary Nail: Early to Medium Results With a Novel Metal-Coated Device." 01/01/2021 - "Therefore, they could be expected to replace traditional metal IN and become a more effective treatment option for tibial fractures." 12/01/1980 - "[Efficient approach to the use of metal screws and screws made of xenogeneic bone tissue in oblique and spiral tibial fractures]." 03/01/1996 - "Current estimates for the cost of treatment of tibial fractures with Thomas splint-cast combinations are $225.00 for calves and $410.00 for cattle if the metal splints are reused. "
6.	Proteins (Proteins, Gene)FDA Link 05/01/2013 - "Bone Morphogenic Proteins have been shown to be effective in fracture non union, and in open tibial fractures. " 01/01/2022 - "After tibial fracture surgery in mice, the hippocampus had increased levels of PeIF2α, ATF4, GADD34, and CHOP protein, ROS-positive cells, and average fluorescence intensity, SOD activity was decreased, and the MDA level was increased. " 01/01/2022 - "Postoperative models of tibial fracture in aged rats were established, including the control group, model group, CCL11 protein injection group, and saline injection group. " 03/30/2019 - "Another 24 male SD rats were randomly divided into control group, tibial fracture group, and tibia fracture with CX3CL1 antibody group, and the behavior indicators and hippocampal CX3L1 protein expression were evaluated after corresponding treatments. " 11/01/2005 - "Recombinant human bone morphogenic protein-2 (rhBMP-2) is an osteoinductive protein that is now available for the acute treatment of open tibial fracture. "
7.	Durapatite (Hydroxylapatite)IBA 01/01/2014 - "In the experiments performed on 16 dogs, an open comminuted tibial fracture was modeled, then wires with hydroxyapatite coating were inserted intramedullary, and osteosynthesis was performed using the Ilizarov fixator. " 01/01/1998 - "Three groups of seven patients had external fixation of middiaphyseal tibial fractures using uncoated pins, uncoated bicylindrical pins, and hydroxyapatite coated bicylindrical pins, respectively. " 12/14/2007 - "This study aimed to assess, through Raman spectroscopy, the incorporation of calcium hydroxyapatite (CHA approximately 958 cm(-1)) on the repair of complete tibial fractures in rabbits treated with wire osteosynthesis (WO); treated or not with laser therapy; and associated or not with the use of BMPs and/or Guided Bone Regeneration. " 01/01/2014 - "In conclusion, the results of the present investigation are important clinically as they are suggestive that the association of hydroxyapatite, and laser light resulted in a positive and significant repair of complete tibial fractures treated with miniplates." 01/01/1995 - "Tissue substitute materials of water and Perspex for soft tissue and aluminium and hydroxyapatite for bone have been combined into phantoms to simulate tibial fractures and have been used to assess the viability of using dual x-ray absorptiometry to quantitatively measure changes in bone density during fracture healing. "
8.	recombinant human bone morphogenetic protein-2IBA 12/01/2009 - "The purpose of this study was to determine the cost savings from a societal perspective for recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in grade III A and B open tibial fractures treated with a locked intramedullary nail and soft-tissue management in the UK, Germany, and France. " 12/01/2002 - "Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients." 06/01/2012 - "Recombinant human bone morphogenetic protein-2 (rhBMP-2) improves healing of open tibial fractures treated with intramedullary nail fixation. " 05/04/2011 - "Recombinant human bone morphogenetic protein-2 (rhBMP-2) improves healing of open tibial fractures treated with unreamed intramedullary nail fixation. " 06/01/2006 - "Recombinant human bone morphogenetic protein-2 in open tibial fractures. "
9.	CollagenIBA 05/04/2011 - "The healing of open tibial fractures treated with reamed intramedullary nail fixation was not significantly accelerated by the addition of an absorbable collagen sponge containing rhBMP-2." 02/01/2007 - "Osteoinduction with rhBMP-7 and bovine collagen was used in 20 patients with distal tibial fractures which had been treated by external fixation (BMP group). " 06/01/2006 - "A total of 510 patients with open tibial fractures were randomized to receive the control treatment (intramedullary nail fixation and routine soft-tissue management) or the control treatment and an absorbable collagen sponge impregnated with one of two concentrations of rhBMP-2. " 09/01/1998 - "We studied the effects of rhBMP-2 in an absorbable collagen sponge (ACS) on bone healing in a large animal tibial fracture model. " 01/01/1994 - "Collagen turnover after tibial fractures was examined in 16 patients with fracture of the tibial diaphysis and in 8 patients with fracture in the tibial condyle area by measuring sequential changes in serological markers of turnover of types I and III collagen for up to 26 weeks after fracture. "
10.	Analgesics (Analgesic Drugs)IBA 01/01/2023 - "To evaluate the analgesic effects of BLA on fracture, we generated tibial fracture mice here. " 01/01/2022 - "Response to: Comment on 'Analgesic effect of music during wound care among patients with diaphyseal tibial fractures: Randomized controlled trial'." 01/01/2021 - "Comment on "Analgesic effect of music during wound care among patients with diaphyseal tibial fractures: Randomized controlled trial"." 01/01/2021 - "Analgesic effect of music during wound care among patients with diaphyseal tibial fractures: Randomized controlled trial." 01/01/2021 - "To evaluate the analgesic effect of music on acute procedural pain during the care of surgical tibial fracture wounds. "

Therapies and Procedures

1.	Intramedullary Fracture Fixation 12/01/2012 - "Interlocking intramedullary nailing is currently the preferred treatment for most tibial fractures requiring operative treatment, with good results and a relatively low complication rate as reported in large clinical series. " 10/01/1999 - "Although the treatment groups are not fully comparable, the results indicate that intramedullary nailing is superior to external fixation in the treatment of most open tibial fractures." 03/01/2021 - "Intramedullary nailing of diaphyseal tibial fractures has become the gold standard method of fixation with high rates of union and low complication rates reported. " 01/01/2014 - "Intramedullary nailing has not yet shown such good outcomes in humeral as in tibial fractures. " 06/01/2004 - "Intramedullary nailing, with appropriate soft-tissue treatment, gives good results in the treatment of open tibial fractures."
2.	External Fixators 01/18/2023 - "The study shows that the distal femoral LCP has good biomechanical stability and adjustability and is superior to the tibial LCP as an external fixator for distal tibial fractures, as long as the technique is used in a standardized manner according to the anatomical studies in this article." 12/01/2011 - "The efficacy of treatment in Ilizarov was higher than that AO external fixator in treatment of open tibial fractures." 10/01/2023 - "The aim of this study is to investigate mechanical properties of minimally invasive plate osteosynthesis (MIPO), supracutaneousplating (SP), and unilateral external fixators (UEF) which can be performed for open tibial fractures. " 01/18/2023 - "Biomechanical study of the stiffness of the femoral locking compression plate of an external fixator for lower tibial fractures." 10/25/2021 - "To study the clinical effect of individualized controllable stress external fixator in the treatment of open tibial fractures. "
3.	Therapeutics 04/01/2001 - "Pulsing electromagnetic field therapy is an effective treatment for ununited tibial fractures with good blood supply to the bone ends." 12/01/2011 - "The VAC therapy may help to reduce the flap size and need for a flap transfer for type IIIB open tibial fractures. " 07/01/1999 - "Consequently, we have initiated a clinical research program to evaluate the safety and efficacy of rhBMP-2 therapy in open tibial fractures. " 11/01/1997 - "The purpose of this study was to identify factors to be considered when selecting the therapy for an isolated tibial fracture in cats and dogs. " 10/01/2017 - "Erratum to: Role of Negative Pressure Therapy as Damage Control in Soft Tissue Reconstruction for Open Tibial Fractures."
4.	Bone Transplantation (Bone Grafting) 11/01/2017 - "The combination of VAC and open bone grafting results in good outcome for patients with open tibial fractures and severe bone and soft-tissue defects." 12/01/1983 - "This treatment scheme used during the early phase of treatment is often effective in producing union of tibial fractures without bone grafting. " 01/01/2010 - "In a patient with multiple risk factors the tibial fracture was completely cured after two attempts of osteosynthesis and autologous bone grafting had failed. " 10/01/2017 - "Our study group was 59 patients with distal two-thirds tibial fractures treated with posterolateral bone grafting. " 07/01/2006 - "The present study suggests that rhBMP-2/allograft is safe and as effective as traditional autogenous bone-grafting for the treatment of tibial fractures associated with extensive traumatic diaphyseal bone loss. "
5.	Debridement 02/01/2023 - "Recent studies suggest pediatric Gustilo-Anderson type I fractures, especially of the upper extremity, may be adequately treated without formal operative debridement, though few tibial fractures have been included in these studies. " 02/03/2021 - "For debridement performed between 12 and 24 hours versus earlier than 12 hours, the OR was higher in tibial fractures (OR = 1.37, 95% CI = 1.00 to 1.87, p = 0.05, I2 = 19%, 12 studies, n = 2,065), and even more so in Gustilo type-IIIB tibial fractures (OR = 1.46, 95% CI = 1.13 to 1.89, p = 0.004, I2 = 23%, 12 studies, n = 1,255). " 12/01/2022 - "Variations in care were observed for timely surgery for severe open tibial fractures with debridement surgery affected by time of presentation and soft-tissue coverage affected by day of presentation and type of hospital. " 10/01/2022 - "We therefore present a technical note detailing the structured approach to the debridement of any open tibial fracture. " 10/01/2022 - "Three-vessel view debridement of the open tibial fracture: a surgical technique."