Thymopoietins (TP 49)

Two closely related polypeptides (molecular weight 7,000) isolated from the thymus gland. These hormones induce the differentiation of prothymocytes to thymocytes within the thymus. They also cause a delayed impairment of neuromuscular transmission in vivo and are therefore believed to be the agent responsible for myasthenia gravis.

Also Known As:

Networked: 58 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Horie-Inoue, Kuniko: 2 articles (07/2020 - 12/2019)
2.	Ikeda, Kazuhiro: 2 articles (07/2020 - 12/2019)
3.	Inoue, Satoshi: 2 articles (07/2020 - 12/2019)
4.	Mitobe, Yuichi: 2 articles (07/2020 - 12/2019)
5.	Bao, Xing: 1 article (01/2022)
6.	Liu, Jidong: 1 article (01/2022)
7.	Tang, Tao: 1 article (01/2022)
8.	Xin, Le: 1 article (01/2022)
9.	Yan, Yukuang: 1 article (01/2022)
10.	Ye, Jinjun: 1 article (01/2022)

Related Diseases

1.	Infections 07/01/1987 - "[Efficacy and tolerability of thymopoietin in patients at risk of infection]." 07/01/1992 - "Thymopentin, a pentapeptide with thymopoietin activity, dramatically increases the resistance to Leishmania major infection in aged mice. " 05/01/1991 - "The effect on peripheral T-lymphocytes of Thymopentin (TP-5), asynthetic pentapeptide reproducing the biological activity of Thymopoietin, is known in Herpes Simplex infections and in Rheumatoid Arthritis. " 11/01/1990 - "A reinfection study on a sample of 40 children (treated and untreated with a pentapeptide identical to the active site of the thymic hormone thymopoietin) seemed to indicate that immunological factors play a significant role in modulating the population dynamics of infection in endemic communities." 01/01/1990 - "In vitro studies with peptides of thymopoietin and splenin justify the assumption that these peptides have therapeutic effects in recurrent herpes simplex infections."
2.	Rheumatoid Arthritis 05/01/1982 - "Thymopoietin in rheumatoid arthritis." 08/01/1981 - "Effects of synthetic thymopoietin II fragments on E-rosette forming cells of a rheumatoid arthritis patient." 01/01/1980 - "14 patients with classical or definite rheumatoid arthritis and a low number of E-rosette forming cells were given single doses of 5 mg and 50 mg of thymopoietin intravenously. " 02/01/1983 - "This supports the conclusions of clinical studies reported elsewhere that levamisole and thymopoietin do not act in the same way in rheumatoid arthritis." 05/01/1982 - "In a controlled study involving 36 patients, thymopoietin was shown to be more effective than levamisole and as effective as penicillamine in improving the clinical status of patients with rheumatoid arthritis. "
3.	Myasthenia Gravis 08/09/1975 - "These data provide further support for the view that myasthenia gravis is a consequence of thymic disease associated with systemic release of thymopoietin, with ensuing neuromuscular block. " 12/01/1983 - "M2 (45Kd protein) was synthesized in thymocytes treated with thymopoietin, in cells from a patient with myasthenia gravis, and in a human T cell line. " 09/15/1971 - "Thymin: a thymic polypeptide causing the neuromuscular block of myasthenia gravis." 09/01/2006 - "Further studies can shed light on the physiological importance of actin filament aggregation with the peptides of thymopoietin, the systematic release of which from the thymus produces the phenomena characteristic for the serious neuromuscular disease myasthenia gravis." 08/09/1975 - "Thymopoietin and myasthenia gravis: neostigmine-responsive neuromuscular block produced in mice by a synthetic peptide fragment of thymopoietin."
4.	Lymphoma (Lymphomas) 01/01/1983 - "Eight patients with cutaneous T-cell lymphomas (6 patients with mycosis fungoides, 1 patient with Sézary's syndrome, 1 patient with low-grade malignant lymphoma, unclassified) were treated with TP-5, a synthetic pentapeptide having the same biologic activity as the thymic hormone thymopoietin. " 05/01/1991 - "Studies of the effect of short-term, intense treatment with thymic hormone on mitogen response, cytotoxicity to EL-4 lymphoma and natural killer cell (NK) activity was investigated Balb/c nude mice (about 12-16-week-old) were treated 5 times per week for 3 weeks with: Facteur Thymic Serique (FTS) and Thymopentin (TP5, Thymopoietin 32-36) at 1 microgram and 10 ng; TM4 1 ng (an enzyme resistant variant of FTS); Thymosin Fraction V (TF5), 10 and 1 microgram; and 0.1 ml saline, and killed 2 days after the last treatment. "
5.	Herpes Simplex 05/01/1991 - "The effect on peripheral T-lymphocytes of Thymopentin (TP-5), asynthetic pentapeptide reproducing the biological activity of Thymopoietin, is known in Herpes Simplex infections and in Rheumatoid Arthritis. " 01/01/1990 - "In vitro studies with peptides of thymopoietin and splenin justify the assumption that these peptides have therapeutic effects in recurrent herpes simplex infections."

Related Drugs and Biologics

1.	Hormones (Hormone)
2.	Thymopentin
3.	Peptides (Polypeptides)
4.	Levamisole (Decaris)
5.	Therapeutic Uses
6.	Enzymes
7.	Penicillamine (Cuprimine)
8.	Mitogens
9.	Immunologic Factors (Immunomodulators)
10.	thymosin fraction 5

Related Therapies and Procedures

1.	Thymectomy