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Thymidylate Synthase

An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
Also Known As:
Thymidylate Synthetase; Synthase, Thymidylate; Synthetase, Thymidylate; 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Networked: 1572 relevant articles (57 outcomes, 216 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Fukushima, Masakazu: 25 articles (01/2015 - 01/2002)
2. Peters, G J: 17 articles (11/2011 - 03/2000)
3. Danenberg, Peter V: 15 articles (05/2014 - 03/2002)
4. Lenz, Heinz-Josef: 13 articles (05/2014 - 01/2002)
5. Danenberg, Kathleen D: 13 articles (01/2014 - 03/2002)
6. Peters, Godefridus J: 12 articles (06/2014 - 01/2002)
7. Fukushima, M: 12 articles (08/2011 - 01/2000)
8. Scagliotti, Giorgio V: 10 articles (09/2015 - 02/2006)
9. Kawakami, Kazuyuki: 10 articles (11/2006 - 09/2002)
10. Marverti, Gaetano: 9 articles (11/2015 - 08/2009)

Related Diseases

1. Colorectal Neoplasms (Colorectal Cancer)
2. Neoplasms (Cancer)
3. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
4. Stomach Neoplasms (Stomach Cancer)
5. Neoplasm Metastasis (Metastasis)

Related Drugs and Biologics

1. Fluorouracil (Carac)
2. Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
3. Thymidine Phosphorylase
4. raltitrexed (D 1694)
5. Enzymes
6. oxaliplatin (Eloxatin)
7. Orotate Phosphoribosyltransferase
8. Leucovorin (Folinic Acid)
9. Messenger RNA (mRNA)
10. pemetrexed (MTA)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Adjuvant Chemotherapy
3. Heterologous Transplantation (Xenotransplantation)
4. Radiotherapy
5. Aftercare (After-Treatment)