|1.||Warkentin, Theodore E: 119 articles (12/2015 - 06/2002)|
|2.||Greinacher, Andreas: 89 articles (11/2015 - 03/2002)|
|3.||Bussel, James B: 59 articles (10/2015 - 08/2003)|
|4.||Hou, Ming: 47 articles (07/2015 - 03/2005)|
|5.||Hursting, Marcie J: 43 articles (01/2011 - 03/2002)|
|6.||George, James N: 42 articles (12/2015 - 01/2002)|
|7.||Greinacher, A: 42 articles (08/2015 - 03/2000)|
|8.||Walenga, Jeanine M: 41 articles (03/2015 - 01/2002)|
|9.||Aster, Richard H: 39 articles (10/2015 - 01/2002)|
|10.||Cines, Douglas B: 35 articles (06/2015 - 02/2002)|
|1.||Heparin (Liquaemin)FDA LinkGeneric
01/01/2008 - "Successful management of acute thromboembolic disease complicated with heparin induced thrombocytopenia type II (HIT II): a case series."
07/01/2007 - "Because of its high sensitivity, we believe the PF4 ENHANCED enzyme-linked immunosorbent assay should be used to identify heparin-induced thrombocytopenia in patients with multiple potential causes of thrombocytopenia, although false-positive results will not be uncommon."
08/01/2005 - "Heparin-induced thrombocytopenia Type II (HIT II) is the autoimmune-mediated severe form of the disease characterized by a significant reduction in platelets, and it carries a high risk of "paradoxical" serious thrombotic complications. "
01/01/2015 - "Safety and efficacy of therapeutic agents used for heparin-induced thrombocytopenia are not established in pregnancy. "
05/01/1997 - "The results of a series of clinical trials reveal that LMWHs are at least as safe and effective as UFH for initial treatment, with the additional advantage of the possibility of home treatment without the requirement of laboratory control and with a reduced risk of heparin-induced thrombocytopenia. "
|2.||Inosine Triphosphate (ITP)IBA
01/01/2015 - "Most children with immune thrombocytopenia (ITP) will have spontaneous remission regardless of therapy, while about 20% will go on to have chronic ITP. "
10/01/2010 - "For most women with ITP, pregnancy is uncomplicated, and even those with severe thrombocytopenia during pregnancy have good outcomes when under the strict care of a hematologist and gynecologist."
05/01/2015 - "pylori is an effective and durable first line treatment for persistent or chronic ITP with moderate thrombocytopenia with high ORR and rapid onset in this study."
01/01/1994 - "The spleen acts as a major site of clearance of antibody-coated platelets from circulation in immune thrombocytopenia (ITP). "
04/01/2003 - "When activity of these disorders is low, standard treatments for ITP are effective for thrombocytopenia. "
11/01/2011 - "She was treated successfully with intravenous immunoglobulin with complete resolution of the thrombocytopenia and no subsequent recurrences."
02/01/1990 - "This thrombocytopenia which had not responded to conventional therapy improved after the third of anti-Rhesus D immunoglobulin infusion, but the efficacy of this treatment could not be proven in this case report. "
09/01/1994 - "High-dose intravenous immunoglobulin was effective in correcting the thrombocytopenia in this second instance. "
09/01/1985 - "In limited experience the administration of high-dose immunoglobulin appears to be effective for antepartum use in patients with immunologic thrombocytopenia. "
10/01/2007 - "Picogram doses of lipopolysaccharide exacerbate antibody-mediated thrombocytopenia and reduce the therapeutic efficacy of intravenous immunoglobulin in mice."
|4.||Intravenous Immunoglobulins (IVIG)FDA Link
03/01/1998 - "The thrombocytopenia improved dramatically after IVIG therapy. "
10/01/2007 - "The therapeutic efficacy of IVIg in antibody-mediated thrombocytopenia was significantly reduced in presence of LPS. "
06/01/2015 - "Anti-CD44 is ineffective at inhibiting thrombocytopenia in B6;129S FcγRIIb-deficient mice but, like IVIG, is effective in splenectomized mice and FcγRIIb-deficient mice on the BALB/C and C57BL/6 background. "
05/01/2005 - "IVIg was first demonstrated to be effective in autoimmune disorders, two decades ago, in the treatment of acute immune thrombocytopenia. "
11/01/2002 - "The authors conclude that IVIG in the dose of 1 g/kg for 1-2 days is an effective treatment for NLE with severe thrombocytopenia especially when corticosteroid is contraindicated."
02/01/2012 - "Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIbα antibodies."
05/01/1998 - "Detailed immunologic studies of antibodies from patients in whom immune thrombocytopenia develops after receiving oral GPIIb/IIIa antagonists may also provide insight into the mechanism by which activated platelets are normally cleared from the circulation."
03/01/2013 - "PTR was observed in patients with anti-HLA class I antibodies and only HLA-matched platelet concentrate (HLA-matched PC) relieved thrombocytopenia. "
10/21/2010 - "Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia."
12/01/2002 - "Measurement of drug-dependent antibodies may be helpful in determining the basis for acute thrombocytopenia in fiban-treated patients and possibly for identification of patients at risk to develop thrombocytopenia."
12/01/2008 - "Randomized trials have shown the short-term efficacy of eltrombopag in elevating the platelet count of most adult patients with immune thrombocytopenia unresponsive to at least one standard treatment. "
03/01/2015 - "Successful discontinuation of eltrombopag after complete remission in patients with primary immune thrombocytopenia."
01/01/2010 - "Based on the current and emerging evidence, a review of the pharmacologic basis, pharmacokinetics, therapeutic efficacy, safety profile and future considerations of eltrombopag in the context of HCV-related thrombocytopenia is given in this article. "
03/01/2010 - "Eltrombopag has shown promising results in the treatment of thrombocytopenia. "
03/01/2015 - "Eltrombopag: a new treatment option for chronic refractory adult immune thrombocytopenia."
|7.||rituximab (Mabthera)FDA Link
02/01/2009 - "Rituximab may be particularly effective for individuals with steroid-refractory cGVHD manifesting as thrombocytopenia or with sclerodermatous, cutaneous, and rheumatologic involvement."
02/01/2009 - "We previously showed in a prospective study that rituximab appears to be effective in some children and adolescents with severe chronic immune thrombocytopenia. "
10/01/2007 - "Our data confirm that rituximab is well tolerated and effective in refractory and relapsed immune thrombocytopenias; however, response duration was short, and only about one fifth of our patients enjoyed a long-lasting remission."
02/01/2015 - "Rituximab is commonly used as a treatment for primary immune thrombocytopenia to induce and maintain remission. "
11/20/2014 - "Safety and efficacy of rituximab in adult immune thrombocytopenia: results from a prospective registry including 248 patients."
|8.||Immunoglobulin G (IgG)IBA
03/01/1996 - "Indirect immunoglobulin G was significantly greater in the 85 women with idiopathic immune thrombocytopenia than in the 129 women with gestational thrombocytopenia (p<0.001). "
08/01/1987 - "To study this question, we measured the in vivo clearance of anti-Rho(D) IgG antibody-sensitized 51Cr-labeled autologous red cells in five homosexual men with thrombocytopenia without an evident cause. "
01/01/2011 - "Enrichment of sialylated IgG by lectin fractionation does not enhance the efficacy of immunoglobulin G in a murine model of immune thrombocytopenia."
11/01/2004 - "Since anti-H/PF4 Abs are mainly IgG1 and IgG3, clearance of sensitized platelets may be increased in patients homozygous for the FcgammaRIIIa-158V allotype, thus contributing to the development of thrombocytopenia."
06/01/2004 - "The severe thrombocytopenia improved drastically after the combination treatment, accompanied with the decrease of the PA IgG titer. "
|9.||Thrombopoietin (c-mpl Ligand)IBA
04/01/2000 - "Identification of TPO, the c-Mpl ligand, as the primary physiologic regulator of megakaryocyte and platelet development offers important promise for treatment of thrombocytopenia. "
09/01/2001 - "Therefore, when transfused into patients with thrombocytopenia, platelets collected from healthy donors undergoing thrombopoietin therapy were safe and resulted in significantly greater platelet count increments and longer transfusion-free intervals than platelets obtained from donors treated with placebo."
01/01/2012 - "However, recent disclosure that an oral thrombopoietin mimetic is effective in increasing platelet count in patients with MYH9-related thrombocytopenia opened new therapeutic perspectives. "
05/01/1995 - "Thrombopoietin also accelerates the recovery of platelets in myelosuppressed animals, suggesting that it will be clinically useful for the treatment of thrombocytopenia."
01/01/2012 - "We report an extended study of 23 pediatric and adult patients suffering from thrombocytopenia with absent radii syndrome in order to scrutinize thrombopoietin signal transduction by immunoblotting and gel electrophoretic shift assays. "
|10.||Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/1986 - "The subsequent recurrent thrombocytopenia was mild and asymptomatic and only partially controlled by corticosteroids but finally resolved completely after 5 months."
03/01/2008 - "After 29 years the biologic exam realized for a generalized purple, relieved a severe thrombocytopenia (2,500/mm3) being necessary the administration of thrombocytes transfusion and high doses of corticosteroids in emergency. "
06/01/2013 - "Corticosteroids as initial therapy for primary immune thrombocytopenia achieve a low rate of sustained remission. "
09/01/2011 - "<title/> Adult patients with primary immune thrombocytopenia requiring first-line treatment typically receive corticosteroids, which are associated with low response rates and many potential side effects. "
11/01/2014 - "The patient was prescribed corticosteroids that are not indicated for drug-induced thrombocytopenia. "
12/01/1999 - "Splenectomy controlled thrombocytopenia with complete remission achieved in 80% (4 from 5) of the patients and 20% (1 from 5) were refractory to this therapy after a medium follow-up time of 6.5 years. "
08/01/1998 - "After splenectomy, six of nine patients with SLE and all three patients with PAPS gained complete remission of thrombocytopenia. "
01/15/1987 - "Twenty-two of the 23 patients with thrombocytopenia less than 100,000/mm3 had complete remission after splenectomy. "
10/01/1982 - "Splenectomy plays an important role in the management of chronic thrombocytopenia when medical treatment is without effect. "
07/01/1978 - "These findings suggest that splenectomy is beneficial in cases where anaemia and thrombocytopenia are not very severe; in severe cytopenia the operation does not increase the life expectancy."
|2.||Drug Therapy (Chemotherapy)
04/01/1986 - "There was a significant increase of urinary Meg-CSF activity during the period of thrombocytopenia after chemotherapy in patients with acute leukaemia who were in complete remission. "
04/01/2000 - "The identification of a safe and effective platelet growth factor could significantly improve the management of severe chemotherapy-induced thrombocytopenia. "
08/01/1996 - "Mice receiving AdCMV.TPO 3 days before receiving irradiation and chemotherapy achieved a platelet nadir fourfold higher, and had significant reduction in duration of thrombocytopenia, than mice receiving the control Ad vector. "
01/01/1990 - "Though the patient tolerated intensive chemotherapy and achieved complete remission, thrombocytopenia persisted after consolidation chemotherapy. "
07/01/1986 - "The combined regimen was more toxic than chemotherapy alone resulting in significantly greater dose reductions and more pronounced thrombocytopenia. "
|3.||Platelet Transfusion (Blood Platelet Transfusions)
11/01/1992 - "Of the 2 responders with marked thrombocytopenia, 1 showed an improvement in the platelet count (7-37 x 10(9)/l) and her regular need for red cell and platelet transfusions ceased. "
08/01/2008 - "Platelet transfusion is the mainstay of treatment for severe thrombocytopenia. "
02/01/2002 - "Improved practice requires definition of a safe lower limit for platelet count in stable neonates; effective platelet transfusion strategies for sick neonates; and improved therapies for conditions precipitating severe thrombocytopenia."
10/01/2013 - "Efficacy of HLA-matched platelet transfusions for patients with hypoproliferative thrombocytopenia: a systematic review."
07/01/2012 - "Thus, we analyzed thrombocytopenia in neonates, its prevalence, and relationship if any, between clinical condition and platelet transfusion in neonates, which would have been helpful in developing guidelines and/or protocols for platelet transfusion (and reducing the donor exposure) in neonates. "
12/01/2002 - "She received early plasma exchange and it markedly improved her thrombocytopenia without sequelae. "
05/01/2009 - "Renal function and thrombocytopenia improved gradually after intensive treatment of plasma exchange (PE) and high-dose steroid therapy. "
12/01/2002 - "Plasma exchange led to recovery from thrombocytopenia and improvement in renal function. "
12/01/2013 - "Here, we report a patient with the clinical presentation of thrombotic microangiopathic thrombocytopenia, normal ADAMTS13, prolonged regimen of therapeutic plasma exchanges (TPEs), bone marrow biopsy showing adequate tri-lineage hematopoiesis, and low immature platelet fraction (%-IPF) (<1.0%). "
04/01/2010 - "The thrombocytopenia and organ failure had resolved after 3 days of plasma exchange therapy. "
|5.||Renal Dialysis (Hemodialysis)
07/01/2012 - "A number of chronic hemodialysis patient cases have been reported in which a marked decrease in platelet count (50% or more) during dialysis was observed, resulting in mild degrees of predialysis thrombocytopenia. "
01/01/2013 - "Regular hemodialysis (3 times per week) improved the patient's thrombocytopenia and thromboasthenia. "
03/01/2013 - "Significant thrombocytopenia following hemodialysis with electron-beam (e-beam) sterilized membranes has been recently reported in a large-scale Canadian study. "
09/01/2009 - "The clinical consequences of HIT in hemodialysis patients remain unclear, with several studies reporting no clinical sequelae and others describing complications such as thrombocytopenia or clotting of the extracorporeal circuit. "
01/01/2016 - "Thrombocytopenia in hemodialysis patients has recently been reported to be commonly caused by electron-beam sterilization of dialysis filters. "