|1.||Gartel, Andrei L: 13 articles (01/2014 - 06/2008)|
|2.||Pandit, Bulbul: 5 articles (10/2011 - 06/2010)|
|3.||Halasi, Marianna: 4 articles (09/2012 - 01/2009)|
|4.||Bhat, Uppoor G: 4 articles (01/2011 - 06/2008)|
|5.||Newick, Kheng: 3 articles (01/2015 - 01/2012)|
|6.||Cunniff, Brian: 3 articles (01/2015 - 01/2012)|
|7.||Wang, Ming: 3 articles (09/2012 - 12/2011)|
|8.||Chen, Hongyan: 2 articles (06/2015 - 11/2014)|
|9.||Wang, Peng: 2 articles (06/2015 - 11/2014)|
|10.||Jiang, Lizhu: 2 articles (06/2015 - 11/2014)|
09/01/2013 - "Results from this study demonstrate a novel action of thiostrepton as inhibitor of the expression of the EWS/FLI1 oncoprotein in vitro and in vivo, and that it shows greater efficacy against EWS than against other tumor types, as it is active on EWS cells and tumors at concentrations lower than those reported to have effective inhibitory activity on tumor cells derived from other cancers. "
09/15/2012 - "Nanoparticle-encapsulated thiazole antibiotic, thiostrepton, has been shown to be an effective agent for inhibiting tumor growth in solid tumor models through the inhibition of proteasomal activity by the induction of apoptosis in cancer cells. "
11/01/2014 - "In a nude mice model, metastatic lung tumor nodules in HPV 18 E6-positive GNM or HPV 16 E6-positive TL-1-injected nude mice were markedly decreased in both cell types with E6 knockdown, FOXM1 knockdown, or treatment with FOXM1 inhibitor (thiostrepton). "
01/01/2014 - "We encapsulated thiostrepton into micelle-nanoparticles and after injection we detected accumulation of nanoparticles in tumors and in the livers of treated mice. "
01/01/2014 - "Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation."
|2.||Liver Neoplasms (Liver Cancer)
12/01/2011 - "In this study, we explored the potential in vivo anticancer properties of thiostrepton, delivered through nanoparticle encapsulation to xenograft models of breast and liver cancer. "
09/15/2012 - "Here, we show the efficacy of thiostrepton-micelles in inhibiting tumor growth in a DEN/PB-induced liver cancer model. "
09/15/2012 - "We also demonstrate an enhanced anticancer effect of the combination treatment of thiostrepton with bortezomib, another proteasome inhibitor in this liver cancer model."
|3.||Melanoma (Melanoma, Malignant)
05/01/2012 - "Using comparative gene expression-array analysis, the early cellular stress response induced by thiostrepton was examined in human A375 metastatic melanoma cells and primary melanocytes. "
05/01/2012 - "Guided by a differential phenotypic drug screen for novel lead compounds that selectively induce melanoma cell apoptosis without compromising viability of primary human melanocytes, we have focused on the cyclic pyridinyl-polythiazolyl peptide-antimicrobial thiostrepton. "
05/01/2012 - "Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes."
12/01/2008 - "Thiostrepton (1 microM) sensitized three out of five melanoma cell lines to ATO-mediated growth inhibition. "
12/01/2008 - "The mechanism of action for the most effective agent identified, thiostrepton, was examined in a panel of melanoma cells. "
|4.||Colonic Neoplasms (Colon Cancer)
06/01/2000 - "In our previous studies of the effects of thiostrepton, a polypeptide antibiotic from streptococcus spp., on erythrocytic schizongony of the human malaria P. "
08/01/1997 - "Although eukaryotes are not generally sensitive to thiostrepton, growth of the human malaria parasite Plasmodium falciparum is severely inhibited by the drug. "
04/01/2011 - "In conclusion, thiostrepton derivatives represent promising candidates for malaria therapy by dually acting on two independent targets, the parasite proteasome and the apicoplast, with the capacity to eliminate both intraerythrocytic asexual and transmission stages of the parasite."
12/01/2001 - "Micrococcin P1, also a potent inhibitor of the malaria parasite Plasmodium falciparum, is structurally related to thiostrepton, thiocillins and nosiheptide. "
08/01/1997 - "Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite."
|5.||Proteasome Endopeptidase Complex (Proteasome)
|6.||Anti-Bacterial Agents (Antibiotics)
|9.||Transcription Factors (Transcription Factor)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)