Thiohydantoins

01/01/2016 - "Design, Synthesis and Biological Evaluation of Thiohydantoin Derivatives as Novel Anti-prostate Cancer Agents."
09/05/2023 - "Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer."
01/01/2021 - "Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer."
01/01/2016 - "A series of novel thiohydantoin derivatives were synthesized and evaluated for the abilities of inhibiting cell proliferation and prostate specific antigen (PSA) expression in prostate cancer cells. "
08/12/2021 - "Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer."

10/01/2019 - "A new series of hybrid structures 14a-l containing thiohydantoin as anti-cancer moiety and pyrazole core possessing SO2Me pharmacophore as selective COX-2 moiety was designed and synthesized to be evaluated for both anti-inflammatory and anti-cancer activities. "
10/01/2019 - "Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities."
10/11/2016 - "Neither the IDO1 inhibitor methyl-thiohydantoin-DL-tryptophan (MTH-trp) nor IFNα alone inhibited RENCA tumor growth, however the combination of MTH-trp and IFNα reduced tumor growth compared to IFNα. "

01/01/2022 - "Our results indicate that thiohydantoins are cytotoxic to breast tumor cells, and this effect is linked to the increase in ROS production. "
01/01/2022 - "The treatment with micromolar doses of thiohydantoins promoted a decrease in the viability of MCF-7 breast tumor cells. "
01/01/2022 - "Patterns of Cell Death Induced by Thiohydantoins in Human MCF-7 Breast Cancer Cells."
09/18/2015 - "One of the thiohydantoin compounds with substituted thiophenyl as the central moiety (compound 15) exhibited potent inhibition of human Top1 (HTop1) through stabilization of Top1-DNA cleavage complexes and showed selective anticancer activity against human cervical carcinoma (HeLa) and breast carcinoma (MCF-7) cell lines. "
01/01/2022 - "Thiohydantoins are biologically active heterocyclic compounds reported for several biological activities, including anticarcinogenic properties, etc. This work aims to assess the use of thiohydantoin as a potential antitumor agent against MCF-7 breast cancer cells. "

05/18/2011 - "A novel series of rhodanin (RH) and thiohydantoin (TH) derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease (AD). "
12/01/2019 - "Then in the next step, the detailed description is followed on their applications in the fields of anticancer activity, drug discovery, and an innovative type of rhodanine (RH) and thiohydantoin (TH) derivatives were created and combined in order to recognize tau pathology in the brains of patients with Alzheimer's disease (AD). "

01/01/1962 - "[Relation of anti-spastic properties and toxicity to the chemical structure of thiohydantoin and rhodanine derivatives]."