Thiamylal (Surital)

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)

Also Known As:

Networked: 103 relevant articles (6 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Jono, Hirofumi: 2 articles (09/2021 - 01/2021)
2.	Morioka, Motohiro: 2 articles (09/2021 - 01/2021)
3.	Negoto, Tetsuya: 2 articles (09/2021 - 01/2021)
4.	Orito, Kimihiko: 2 articles (09/2021 - 01/2021)
5.	Saito, Hideyuki: 2 articles (09/2021 - 01/2021)
6.	Takeshige, Nobuyuki: 2 articles (09/2021 - 01/2021)
7.	Yamakawa, Yukako: 2 articles (09/2021 - 01/2021)
8.	Yoshitomi, Munetake: 2 articles (09/2021 - 01/2021)
9.	Maruyama, Azusa: 2 articles (08/2020 - 07/2014)
10.	Nagase, Hiroaki: 2 articles (08/2020 - 07/2014)

Related Diseases

1.	Ischemia 04/01/2000 - "This study investigated the effects of thiamylal on the activities of KATP channels in isolated rat ventricular myocytes during simulated ischemia. " 03/01/2001 - "Clinical doses of propofol had no significant effect on myocardial function and [Ca2+]i before and after ischemia, whereas thiamylal suppressed the increase in [Ca2+]i during ischemia and reperfusion. " 03/01/2001 - "Effects of propofol on ischemia and reperfusion in the isolated rat heart compared with thiamylal." 07/01/1990 - "These results indicate that thiamylal, ketamine and nicardipine have different effects on the ischemia of hippocampus." 04/01/2001 - "Thiopental (400 microM), thiamylal (400 microM), and ketamine (100 microM), but not propofol (100 microM) and etomidate (10 microM), improved the recovery of PS after 6 and 7.5 mins ischemia; the degrees of their protection were comparable to that of 5 microM CPP. "
2.	Pain (Aches) 06/01/1994 - "Pain on injection was observed in 5 cases of thiamylal group but in no cases of combination group. " 06/01/1994 - "Midazolam has a slow onset of action, while thiamylal causes pain on injection and circulatory changes. " 12/01/1981 - "These findings indicate that the antianalgesic action of thiamylal is induced at the spinal cord level: although this anesthetic agent does have a direct intraspinal depressant action, the multisynaptic neural network of the supraspinal pain inhibition system is more susceptible to the actions of anesthetics, and the depression of this descending system by thiamylal results in a release of spinal cord nociceptive neural mechanisms from the supraspinal control." 01/04/2021 - "The number of additional injections of thiamylal sodium to manage discomfort and pain during ablation were significantly lower in the fentanyl group. " 08/01/1997 - "However, the fact that only 23 of the present 39 cases (59.0%) of thalamic and suprathalamic pain were sensitive to the thiamylal or ketamine test reflects the complex pharmacological background and the difficulties associated with treating central post-stroke pain."
3.	Hypoxia (Hypoxemia) 09/01/2009 - "Both thiopental and thiamylal reversibly suppressed hypoxia-induced HIF-1 activation in the neuronal and the non-neuronal cells in a dose-dependent manner. " 06/01/1991 - "Arterial ketone body ratio (AKBR), which indicates the mitochondrial energy charge level, decreased with the development of hypoxia, and in the hypoxia-halothane group, the decrease of AKBR was significantly greater than in the hypoxia-thiamylal group at FIO2 0.08. " 06/01/1991 - "These results suggest that, compared with halothane, thiamylal could suppress the exaggerated reaction to hypoxic hypoxemia, maintain hepatic circulation and hepatic oxygen metabolism and therefore maintain the hepatic mitochondrial redox state in better condition." 06/01/1991 - "In the hypoxia-halothane group, however, the increase of norepinephrine was significantly higher than in the hypoxia-thiamylal group at FIO2 0.08. " 06/01/1991 - "In the hypoxia-halothane group, portal venous blood flow (FIO2 0.15-0.10), portal venous oxygen content (FIO2 0.10-0.08) and hepatic oxygen consumption (FIO2 0.08) significantly decreased compared with the hypoxia-thiamylal group. "
4.	Temporomandibular Joint Disorders (Temporomandibular Joint Disorder) 03/01/2004 - "In the operating room her mouth opening was ascertained to be 5 cm. Anesthesia was induced with thiamylal 250 mg, fentanyl 0.1 mg and vecuronium 6 mg i.v. Her mouth opening was found reduced to 2 cm that was not improved by additional vecuronium 2 mg. A consulted oral surgeon diagnosed temporomandibular disorder. "
5.	Myoclonus (Nocturnal Myoclonus) 08/01/2002 - "Thiamylal, propofol and benzodiazepines were effective in the prevention of myoclonus-like seizure. "

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	Ketamine
3.	Halothane (Fluothane)
4.	Thiopental (Pentothal)
5.	Vecuronium Bromide (Vecuronium)
6.	Lidocaine (Xylocaine)
7.	Fentanyl (Sublimaze)
8.	Morphine (MS Contin)
9.	Benzodiazepines
10.	Citric Acid (Citrate)

Related Therapies and Procedures

1.	Therapeutics
2.	Anesthesia
3.	General Anesthesia
4.	Intravenous Administration
5.	Artificial Respiration (Mechanical Ventilation)