Thiamine Pyrophosphatase

An enzyme that hydrolyzes thiamine pyrophosphate to thiamine monophosphate plus inorganic phosphate. EC 3.6.1.-.

Also Known As:

Thiamine Pyrophosphate Phosphohydrolase; Phosphohydrolase, Thiamine Pyrophosphate; Pyrophosphatase, Thiamine; Pyrophosphate Phosphohydrolase, Thiamine; TPPase

Networked: 25 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Pyrophosphatases: 171
        Nudix Hydrolases: 42
        Thiamine Pyrophosphatase: 25

Related Diseases

1.	Ulcer 06/01/1987 - "Using electron microscopic studies the location of thiamine pyrophosphatase (TPPase) activity in the epithelial cells of duodenal mucosa was investigated in 39 patients with ulcer exacerbation and during the disease remission. "
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 06/01/1992 - "Thiamin-pyrophosphatase (TPPase) and thiamin-monophosphatase (TMPase) were determined using a spectrophotometric method at various pH values (5.5, 7.5, and 9.0) in brain tissue obtained at autopsy from amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) patients from Guam and from Guamanian patients who died from other diseases (controls). " 06/01/2023 - "Homogenates of brain tissue from the frontal cortex at autopsy in patients with amyotrophic lateral sclerosis (ALS) showed dramatically reduced levels of the enzyme thiamine pyrophosphatase (TPPase), the enzyme responsible for the conversion of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). "
3.	Stomach Neoplasms (Stomach Cancer) 11/01/1995 - "The distribution of ALPase, ACPase, G6Pase TPPase and CCOase of gastric cancer and normal gastric epithelium were studied ultrastructurally. " 06/15/1997 - "To study the ultrastructural localization of five marker enzymes (ALPase, ACPase, G6Pase, TPPase and CCOase) in gastric cancer signet ring cells to demonstrate their biologic behaviors. " 06/15/1997 - "The number of corresponding organelles and the activities of marker enzymes, especially ACPase and TPPase, increased, leading to stronger mucus synthesis, secretion and digestion in gastric cancer signet ring cells. "
4.	Hepatocellular Carcinoma (Hepatoma) 10/01/1989 - "Dynamic distribution of the Golgi marker thiamine pyrophosphatase is modulated by brefeldin A in rat hepatoma cells." 10/01/1989 - "Cytochemical electron microscopy of cultured rat hepatoma cells (AH-130) demonstrated that thiamine pyrophosphatase (TPPase) activity was localized in the Golgi complex. " 01/01/1983 - "A cytochemical study of acid phosphatase, thiamine pyrophosphatase and horseradish peroxidase in the Golgi-GERL complex of hepatoma ascites cells."
5.	Ascites 01/01/1983 - "A cytochemical study of acid phosphatase, thiamine pyrophosphatase and horseradish peroxidase in the Golgi-GERL complex of hepatoma ascites cells." 01/01/1982 - "Thiamine pyrophosphate (TPP) content, activities of thiamine pyrophosphokinase (TPKase), thiamine pyrophosphatase, transketolase (TK), pyruvate (PDG) and oxoglutarate dehydrogenases (OGDG) were measured in the liver and cells of Ehrlich ascites carcinoma (EAC) on the 5th, 10th and 15th day after transplantation of the tumor to mice fed a thiamine-deficient diet. "

Related Drugs and Biologics

1.	Thiamine Pyrophosphatase
2.	Enzymes
3.	Thiamine Pyrophosphate
4.	Thymidine Monophosphate (TMP)
5.	Thiamine Monophosphate
6.	Acid Phosphatase
7.	Horseradish Peroxidase
8.	Thiamine (Aneurin)
9.	Oxidoreductases (Dehydrogenase)
10.	5'-Nucleotidase (5' Nucleotidase)

Related Therapies and Procedures

1.	Transplantation