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Thecoma (Thecomas)

A gonadal stromal neoplasm composed only of THECA CELLS, occurring mostly in the postmenopausal OVARY. It is filled with lipid-containing spindle cells and produces ESTROGENS that can lead to ENDOMETRIAL HYPERPLASIA; UTERINE HEMORRHAGE; or other malignancies in postmenopausal women and sexual precocity in girls. When tumors containing theca cells also contain FIBROBLASTS, they are identified as thecoma-fibroma tumors with less active hormone production.

Also Known As:

Thecomas; Theca Cell Tumors; Tumor, Theca Cell; Tumors, Theca Cell; Theca Cell Tumor

Networked: 81 relevant articles (1 outcomes, 3 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Peritonitis
2.	Neoplasms (Cancer)
3.	Fibroma (Fibromatosis)
4.	Granulosa Cell Tumor
5.	Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor)

Experts

1.	Suzuki, Takashi: 2 articles (12/2007 - 05/2007)
2.	Prat, Jaime: 2 articles (07/2005 - 09/2004)
3.	Catasus, Lluis: 2 articles (07/2005 - 09/2004)
4.	Taya, Kazuyoshi: 2 articles (06/2003 - 06/2003)
5.	Osawa, Takeshi: 2 articles (06/2003 - 06/2003)
6.	Miyake, Yoh-Ichi: 2 articles (06/2003 - 06/2003)
7.	Hoque, Shafiqul: 2 articles (06/2003 - 06/2003)
8.	Derar, Refaat Ibrahim: 2 articles (06/2003 - 06/2003)
9.	Perretta, Rosanna C: 1 article (07/2009)
10.	Noyes, Nicole: 1 article (07/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thecoma:

1.	Toremifene (Fareston)FDA Link 03/01/2005 - "Ovarian luteinized thecoma with sclerosing peritonitis in an adult woman treated with leuprolide and toremifene in complete remission at 5 years." Order ALL the reference details at left...
2.	Leuprolide (Lupron)FDA LinkGeneric 03/01/2005 - "Ovarian luteinized thecoma with sclerosing peritonitis in an adult woman treated with leuprolide and toremifene in complete remission at 5 years." Order ALL the reference details at left...
3.	Inhibins (Inhibin)IBA 11/01/1999 - "Dimeric inhibin concentrations in mares with granulosa-theca cell tumors." 12/01/1997 - "In contrast, 10 of 14 (71%) ovarian fibroma-thecomas and 17 of 18 (94%) other sex cord-stromal proliferations were positive for inhibin. " 09/01/2001 - "Previous studies of inhibin-alpha-positive lesions reported in the literature include sex cord stromal tumors (granulosa cell tumors, luteinized thecomas, Leydig cell tumors), placental and gestational trophoblastic lesions, and adrenal cortical tumors. " 12/01/1997 - "The results of this study show that although it is not completely specific and cannot reliably distinguish granulosa cell tumors from fibroma-thecomas or other ovarian sex cord-stromal proliferations, inhibin can be used to help distinguish sex cord-stromal neoplasms from most primary and metastatic non-SCST. " 09/01/2008 - "Immunostaining for inhibin was positive in 66% of granulosa cell tumor, in 50% of Sertoli-Leydig cell tumor and in 54% of thecoma-fibroma group. " Order ALL the reference details at left...
4.	Estrogens (Estrogen)FDA Link 03/01/2004 - "Seven patients were on unopposed estrogen, four on combined estrogen-progestin therapy, and one patient had a synchronous ovarian thecoma. " 10/01/2004 - "Our patient was found to have estrogen-producing thecoma accompanied by accumulation of ascites in an early phase of pregnancy. " 01/01/1997 - "Women at high risk, as a result of excess estrogenic stimulation are those with polycystic ovaries, long-standing estrogen users and functioning granulosa cell tumors and thecomas. " 12/01/1983 - "Long-term culture of human ovarian theca cell tumor, an estrogen-producing tumor." 11/01/1975 - "Breast carcinomas required the largest amount of estrogen for growth, whereas ovarian thecomas would grow in normal females but not in males. " Order ALL the reference details at left...
5.	Testosterone (Sustanon)FDA Link 07/01/2000 - "A testosterone-producing thecoma was found on histopathology. " 07/01/2000 - "Testosterone-producing thecoma in a female cat." 06/01/2002 - "The simultaneous occurrence of a virilizing ovarian steroid cell tumor and an apparently non-functioning thecoma within the contralateral ovary emphasizes the potential pitfalls that may exist in the preoperative evaluation of patients with markedly increased testosterone production." 01/01/1990 - "Immunoreactivity of steroids was not observed in thecomas except for testosterone immunoreactivity in one case. " 01/01/1980 - "A case of a progressive virilizing solid granulosa-theca cell tumor producing high testosterone levels that were suppressed to normal by a course of oral contraceptives is presented. " Order ALL the reference details at left...
6.	Progesterone FDA LinkGeneric 01/01/1990 - "Immunohistochemical study of estrogen, progesterone, and testosterone was also performed in serial sections of thecomas and fibromas. " 01/01/1990 - "3 beta-Hydroxysteroid dehydrogenase (3 beta-HSD), which converts pregnenolone to progesterone, was localized immunohistochemically in 18 thecomas, 23 fibromas, 5 granulosa-cell tumors, 5 sclerosing stromal tumors, and 2 steroid-cell tumors. " Order ALL the reference details at left...
7.	HormonesIBA 01/01/1995 - "By caval-portal shunt, ovarian hormones enter directly into the portal blood stream and no typical granulosa-theca cell tumors were produced, owing to the fact that the liver cannot degrade all the hormones secreted by both ovaries. " 01/01/1987 - "A very rare extraovarian hormone-producing thecoma, originated from the broad ligament, is described. " 01/01/1987 - "A hormone-producing thecoma of broad ligament." 12/01/1986 - "These results are compatible with the concept that in granulosa-theca cell tumor, both granulosa and theca cells can produce a wide range of steroid hormones." 07/01/2009 - "Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis." Order ALL the reference details at left...
8.	VimentinIBA 05/01/1992 - "Two sclerosing stromal tumors and both thecomas were vimentin positive. " 08/01/1987 - "Thecomas and fibromas expressed vimentin only. " 05/01/1994 - "In neoplasia, the GCTs, thecomas, fibromas, and sclerosing stromal tumors expressed vimentin only.(ABSTRACT TRUNCATED AT 250 WORDS)" 08/01/1987 - "The expression of the intermediate filaments cytokeratin and vimentin were studied immunohistochemically in a series of ovarian sex cord-stromal tumours (26 adult and juvenile granulosa cell tumours, 11 thecomas, six fibromas, three Sertoli-Leydig cell tumours and 1 sex cord tumour with annular tubules). " 05/01/1994 - "A total of 30 sex cord-stromal tumors including 9 adult type and 5 juvenile type granulosa cell tumors (GCTs), 4 Sertoli-Leydig cell tumors (SLTs), 1 gynandroblastoma, 5 thecomas, 2 fibromas and 3 sclerosing stromal tumors were immunohistochemically evaluated by means of cytokeratins of different molecular weight, vimentin and laminin with regard to the histogenesis of these tumors and to the embryogenesis of the sex cord and stroma of developing gonads. " Order ALL the reference details at left...
9.	SteroidsIBA 09/15/2006 - "Granulosa-theca cell tumors (GTCTs) are able to secrete variable amounts of sex steroids and immunoreactive inhibin (ir-INH). " 01/01/1990 - "Immunoreactivity of steroids was not observed in thecomas except for testosterone immunoreactivity in one case. " 03/01/1977 - "Eighty-one patients took oral contraceptives; six were associated with pregnancy; three had taken estrogens for long periods of time; one had a thecoma; four never took sex steroids; and in five the history was unknown. " Order ALL the reference details at left...
10.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 12/01/2008 - "Luteinized thecoma associated with sclerosing peritonitis--conservative surgical approach followed by corticosteroid and GnRH agonist treatment--a case report." 09/15/2006 - "Gonadotropin secretion and pituitary responsiveness to GnRH in mares with granulosa-theca cell tumor." 03/01/2005 - "DISCUSSION: Antiestrogens plus LHRH agonists might be a noninvasive, effective and well-tolerated therapy for sclerosing peritonitis in patient operated for luteinized thecomas." Order ALL the reference details at left...

Therapies and Procedures

1.	Ovariectomy (Oophorectomy) 01/01/2008 - "A 65-year-old woman presenting with a SCST underwent a bilateral oophorectomy, the histology was unusual but likely to be a luteinized thecoma with suspicious features for invasion. " 06/01/2003 - "Spontaneous repair of the atrophic contralateral ovary without ovariectomy in the case of a granulosa theca cell tumor (GTCT) affected mare." 07/01/2007 - "An ovariectomy was performed and histological examination revealed a thecoma fibroma. " Order ALL the reference details at left...
2.	Radiotherapy 02/01/2002 - "The prognosis of malignant thecomas is poor, postoperative systemic chemotherapy or radiotherapy to the patients with malignant thecomas can improve their survival." 02/01/2002 - "Among 8 patients with malignant thecoma, 4 patients without postoperation therapy or with non-standard chemotherapy died in 2 years postoperation, the other 4 patients received operation, postoperational radiotherapy or (and) chemotherapy, 1 of 4 patients died of irradiation intestinal fistule 4 years later; two patients are alive without disease more than 10 years, another one for 2 years. " 01/01/1980 - "Nineteen women with granulosa-cell tumor and 4 with thecoma had received radiotherapy earlier in life for benign lesions. " Order ALL the reference details at left...
3.	Transplants (Transplant) 01/01/1995 - "As to the ovarian transplants, granulosa-theca cell tumors may transform into malignancies if followed for a prolonged period as intrasplenic ovaries, and high doses (15 to 20 mg/kg b.w.) of azathioprine can produce such malignant tumors in a shorter period. " Order ALL the reference details at left...
4.	Rejuvenation 11/20/1954 - "[Theca cell tumor with prolonged hemorrhage in the menopause and fibromyoma the uterus in a 69 year old patient with appearance of rejuvenation.]" Order ALL the reference details at left...
5.	Laparotomy 07/01/1992 - "At laparotomy, a luteinized thecoma and cytologically benign ascites were found. " Order ALL the reference details at left...

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