Tetrahydropapaveroline

A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.

Also Known As:

Norlaudanosoline; Tetrahydroxypapaveroline; 6,7-Isoquinolinediol, 1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-

Networked: 20 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Surh, Young-Joon: 4 articles (09/2010 - 11/2003)
2.	Jang, Jung-Hee: 3 articles (12/2007 - 11/2003)
3.	Shin, Mi-Hyun: 2 articles (05/2004 - 11/2003)
4.	Soh, Yunjo: 2 articles (11/2003 - 06/2003)
5.	Brown, R A: 2 articles (01/2001 - 06/2000)
6.	Pavlik, M L: 2 articles (01/2001 - 06/2000)
7.	Ren, J: 2 articles (01/2001 - 06/2000)
8.	Kim, Hyun-Jung: 1 article (09/2010)
9.	Cha, Young-Nam: 1 article (12/2007)
10.	Li, Mei-Hua: 1 article (12/2007)

Related Diseases

1.	Glioma (Gliomas) 11/01/2003 - "Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline." 06/01/2003 - "Protective effects of quinic acids from Aster scaber on tetrahydropapaveroline (THP)-induced cell toxicity were evaluated in rat C6 glioma cells. " 06/01/2003 - "Protective effects of quinic acid derivatives on tetrahydropapaveroline-induced cell death in C6 glioma cells."
2.	Alcoholism (Alcohol Abuse) 09/11/1970 - "Alcohol addiction and tetrahydropapaveroline." 09/11/1970 - "Alcohol addiction and tetrahydropapaveroline." 01/01/2004 - "Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler." 05/01/1999 - "Since the 1970s tetrahydropapaveroline (THP) and other tetrahydroisoquinoline alkaloids have been implicated in the etiology of alcoholism. " 09/01/2010 - "Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. "
3.	Parkinson Disease (Parkinson's Disease) 05/01/1974 - "[Preliminary clinical trial of tetrahydropapaveroline in Parkinson's disease]." 01/01/2004 - "Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler." 11/01/2003 - "Tetrahydropapaveroline [THP; 6,7-dihydroxy-1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline], a dopamine-derived tetrahydroisoquinoline alkaloid, has been reported to inhibit mitochondrial respiration and is considered to contribute to neurodegeneration implicated in Parkinson's disease. " 09/01/2010 - "Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. "
4.	Hypertension (High Blood Pressure) 02/01/2002 - "Influence of hypertension on tetrahydropapaveroline-induced vasorelaxation in rat thoracic aorta." 01/01/2001 - "Loss of cardiac contractile response to tetrahydropapaveroline with advanced age and hypertension." 06/01/2000 - "Diminished cardiac contractile response to tetrahydropapaveroline in hypertension: role of beta-adrenoceptors and intracellular Ca(2+)."
5.	Parkinsonian Disorders (Parkinsonism) 12/01/2007 - "Tetrahydropapaveroline (THP), a dopaminergic isoquinoline neurotoxin, has been reported to contribute to neurodegeneration in parkinsonism. " 05/01/2004 - "Tetrahydropapaveroline (THP), a dopamine-derived tetrahydroisoquinoline catechol, has been suspected to be dopaminergic neurotoxin that elicits parkinsonism and neurobehavioral abnormalities associated with chronic alcoholism. "

Related Drugs and Biologics

1.	Quinic Acid (Quinate)
2.	Acids
3.	Alkaloids
4.	1,2,3,4-tetrahydroisoquinoline
5.	Dopamine (Intropin)
6.	2- methyl- 4- carboxy- 5- hydroxy- 3,4,5,6- tetrahydropyrimidine
7.	Neurotoxins
8.	Morphine (MS Contin)
9.	catechol (pyrocatechol)
10.	Benzylisoquinolines