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Tetrahydrofolates

Compounds based on 5,6,7,8-tetrahydrofolate.
Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Beveridge, Susan: 1 article (12/2011)
2. Bray, Patrick G: 1 article (12/2011)
3. O'Neill, Paul M: 1 article (12/2011)
4. Ochong, Edwin: 1 article (12/2011)
5. Krishna, Sanjeev: 1 article (12/2011)
6. Johnson, David: 1 article (12/2011)
7. Ward, Stephen A: 1 article (12/2011)
8. Salcedo-Sora, J Enrique: 1 article (12/2011)
9. Biagini, Giancarlo A: 1 article (12/2011)
10. Nzila, Alexis: 1 article (12/2011)

Related Diseases

1. Adenocarcinoma
06/01/1988 - "Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma."
06/15/1990 - "Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts."
01/01/1989 - "Four hr infusions i.v. of [6RS]5-formyltetrahydrofolate ([6RS]5-CHO-H4PteGlu; 500 mg/m2) and [6RS]5-methyltetrahydrofolate ([6RS]5-CH3-H4PteGlu; 500 mg/m2) were compared for their relative effects on expansion of pools of 5,10-methylenetetrahydrofolates (CH2-H4PteGlun) and tetrahydrofolates (H4PteGlun) in two human colon adenocarcinoma xenografts in mice. "
06/15/1990 - "Using preclinical models of human colon adenocarcinomas as xenografts in immune-deprived mice, the effect of the rate of administration of racemic [6RS]leucovorin on the concentration-time profile of reduced folates in plasma, size of intratumor pools of 5,10-methylenetetrahydrofolates (CH2-H4PteGlun) and tetrahydrofolates (H4PteGlun), and the distribution of their polyglutamate species have been examined. "
07/01/1990 - "Using preclinical models of human colon adenocarcinomas in immune-deprived mice, the influence of dose of [6RS]leucovorin ([6RS]LV, 20 to 1000 mg/m2) administered by 24-h i.v. infusion was determined on the following parameters: (a) plasma concentrations of the active [6S] and inactive [6R] isomers of [6RS]LV and the biologically active diastereoisomer of 5-methyltetrahydrolate (5-CH3-H4PteGlu); (b) expansion of intratumor pools of 5,10-methylenetetrahydrofolates (CH2-H4PteGlun) and tetrahydrofolates (H4PteGlun), that may influence the binding of 5-fluorodeoxyuridylate to thymidylate synthase; (c) the distribution of polyglutamate forms of CH2-H4PteGlun and H4PteGlun; and (d) (5-fluorouracil (FUra)-mediated thymidylate synthase inhibition in Hx-ELC2, HxGC3, HxVRC5, and HxHC1 tumors. "
2. Neoplasms (Cancer)
3. Malaria
4. Non-Hodgkin Lymphoma (Lymphosarcoma)
5. Leukemia L1210

Related Drugs and Biologics

1. Leucovorin (Folinic Acid)
2. Polyglutamic Acid (Polyglutamate)
3. Thymidylate Synthase
4. Folic Acid (Vitamin M)
5. Fluorouracil (Carac)
6. 5,6,7,8-tetrahydrofolic acid (tetrahydrofolate)
7. 5-methyltetrahydrofolate

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)