|1.||Lichtman, Aron H: 18 articles (09/2015 - 08/2002)|
|2.||Guzmán, Manuel: 12 articles (11/2015 - 04/2002)|
|3.||Velasco, Guillermo: 12 articles (06/2015 - 04/2002)|
|4.||Huestis, Marilyn A: 11 articles (11/2014 - 11/2004)|
|5.||Haney, Margaret: 11 articles (09/2013 - 08/2002)|
|6.||Martin, Billy R: 11 articles (04/2008 - 07/2002)|
|7.||Sim-Selley, Laura J: 10 articles (09/2015 - 10/2002)|
|8.||Lorente, Mar: 10 articles (06/2015 - 08/2007)|
|9.||Wiley, Jenny L: 10 articles (07/2014 - 06/2003)|
|10.||Selley, Dana E: 9 articles (09/2015 - 02/2008)|
12/01/1998 - "On the other hand, THC and its synthetic derivatives have been shown to be effective in most animal models of pain. "
08/01/2007 - "We observed a significant improvement of SSS with active drug (P=0.001) in the seven subjects who received oral THC in Phase 1 and placebo in Phase 3. Major reasons for drop out were increase of pain and psychological side effects. "
11/01/2009 - "Considerable preclinical research has demonstrated the efficacy of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of animal models of pain, but few studies have examined other phytocannabinoids. "
09/01/2013 - "We tested the hypothesis that THC is more effective in females than males using a model of longer-lasting, inflammatory pain. "
08/01/2014 - "Several pharmaceutical products with defined natural or synthesized Δ9-THC content have been developed, resulting in increasing numbers of clinical trials investigating the analgesic efficacy of dronabinol in various pain conditions. "
07/15/2002 - "Treatment of EL-4 tumor-bearing mice with THC in vivo led to a significant reduction in tumor load, increase in tumor-cell apoptosis, and increase in survival of tumor-bearing mice. "
07/15/2002 - "Exposure of murine tumors EL-4, LSA, and P815 to delta-9-tetrahydrocannabinol (THC) in vitro led to a significant reduction in cell viability and an increase in apoptosis. "
11/01/1991 - "In both HIV and cancer patients, dronabinol improved appetite at a dose which was well tolerated for chronic administration."
06/01/2015 - "Using a strict approach where only concentrations and/or models relevant to the clinical situation are considered, the current preclinical data do not yet provide robust evidence that systemically administered Δ(9) -THC will be useful for the curative treatment of cancer. "
04/01/2015 - "In univariate analysis, THC was significantly correlated with the following prognostic factors: tumor size (P < .001), histologic grade (P < .001), ER (P < .05), PR (P < .001), and c-erbB-2 (P < .05). "
05/01/2001 - "The lowest significantly effective antiemetic dose of Delta(9)-THC for the latter emesis parameters was 2.5 mg/kg. Although Delta(9)-THC reduced the frequency of vomits up to 98%, it failed to completely protect all tested shrews from vomiting (80% protection). "
08/01/2008 - "The present study indicates that Delta(9)-THC, acting via the CB(1) receptors, is anti-emetic to motion, and that CBD has no effect on motion-induced emesis in Suncus murinus."
10/01/2013 - "In S. murinus, THCA (0.05 and 0.5 mg·kg(-1) ) reduced LiCl-induced vomiting, an effect that was reversed with SR. A comparatively low dose of THC (0.05 mg·kg(-1) ) did not suppress conditioned gaping to a LiCl-paired flavour or context. "
11/24/2010 - "The inhibition of 5-HT(3) receptors by THC may contribute to its pharmacological actions in nociception and emesis."
01/01/2004 - "The effects of THC and CBD on vomiting were dose dependent; with THC the effect was linear, but with CBD the effect was biphasic."
12/01/2015 - "Combined subthreshold doses of THC:CBDA are particularly effective as a treatment for acute nausea. "
02/01/1995 - "Dronabinol was associated with increased appetite above baseline (38% vs 8% for placebo, P = 0.015), improvement in mood (10% vs -2%, P = 0.06), and decreased nausea (20% vs 7%; P = 0.05). "
12/01/2015 - "However, higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 μg/kg) alone, as well as these combined doses, also reduced anticipatory nausea. "
12/01/2015 - "On the other hand, combined subthreshold doses of THC (0.01 and 0.1 mg/kg) and CBDA (0.01 and 0.1 μg/kg) did not suppress contextually elicited conditioned gaping in a test for anticipatory nausea. "
12/01/2015 - "Higher doses of THC (1.0, 10 mg/kg) or CBDA (1.0, 10 μg/kg) alone, as well as these combined doses also reduced acute nausea. "
02/01/2004 - "Delta(9)-THC alone produced slightly greater antinociception, and significantly greater catalepsy in females than males. "
09/01/2014 - "On the morning or afternoon of day 8 or day 9, vehicle or THC (100 μg) was administered i.c.v. Paw pressure, tail withdrawal, locomotor activity and catalepsy tests were conducted over a 3-h period. "
04/15/2012 - "Enhanced tolerance to THC-induced catalepsy was observed in βarr2-KO mice. "
09/01/2011 - "THC alone also produced paw pressure antinociception and decreased locomotor activity, but did not produce catalepsy. "
01/24/2008 - "Bilateral microinjection of THC into the NAc region induced catalepsy-like immobilization. "
|5.||Blood Glucose (Blood Sugar)
|6.||Opioid Analgesics (Opioids)
|8.||Cannabinoid Receptors (Cannabinoid Receptor)
|1.||Drug Therapy (Chemotherapy)
|5.||Estrogen Replacement Therapy