Tetrabenazine (Nitoman)

A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.

Also Known As:

Nitoman; Xenazine; 2H-Benzo(a)quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-

Networked: 357 relevant articles (48 outcomes, 35 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolizines: 1
      - Tetrabenazine: 357
        valbenazine: 85
        deutetrabenazine: 83
        dihydrotetrabenazine: 62
        florbenazine F 18: 10
        (11C)-(+)-alpha-dihydrotetrabenazine: 2
        5-O-methyldihydrotetrabenazine: 1
        2-N-((3'-iodo-4'-azidophenyl)propionyl)tetrabenazine
        9-benzyloxy-alpha-dihydrotetrabenazine
        9-fluoroethyldihydrotetrabenazine
        N-(3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizin-2-yl)-4-((4-azido-2-nitrophenyl)amino)butanamide

Experts

1.	Jankovic, Joseph: 19 articles (03/2019 - 11/2002)
2.	Frank, Samuel: 8 articles (01/2017 - 05/2008)
3.	Ondo, William G: 8 articles (08/2012 - 11/2002)
4.	Claassen, Daniel O: 7 articles (03/2022 - 01/2017)
5.	Hunter, Christine: 7 articles (01/2017 - 01/2007)
6.	Ferreira, Joaquim J: 4 articles (01/2022 - 01/2017)
7.	Rodrigues, Filipe B: 4 articles (01/2022 - 01/2017)
8.	Sampaio, Cristina: 4 articles (01/2022 - 07/2009)
9.	Killoran, Annie: 4 articles (02/2019 - 09/2014)
10.	Schultz, Jordan L: 4 articles (02/2019 - 01/2018)

Related Diseases

1.	Chorea (Rheumatic Chorea) 12/01/2011 - "The antichorea efficacy of tetrabenazine was maintained in an 80-week extension study (n = 75), with the adjusted mean UHDRS total maximum chorea score significantly (p < 0.001) reduced from baseline (score of 14.9) by 4.6 points (primary outcome). " 03/01/2015 - "On the basis of some research evidence and clinical experience, tetrabenazine may be effective in treating chorea. " 01/01/2012 - "This pilot study demonstrates tetrabenazine's potential effects beyond improvement in chorea." 01/01/2022 - "Tetrabenazine improved chorea. " 01/01/2013 - "Tetrabenazine treatment was associated with long-term improvement in chorea. "
2.	Tardive Dyskinesia 04/01/2011 - "Small trials indicate tetrabenazine may be effective for the treatment of tardive dyskinesia. " 04/01/1985 - "Although tetrabenazine masked symptoms in 5 of 7 patients to whom it was administered, none was able to achieve remission of tardive dyskinesia when taken off the drug. " 08/01/2019 - "These agents were pharmacologically modified from tetrabenazine, a VMAT2 inhibitor used off-label in the treatment of tardive dyskinesia. " 05/01/2013 - "As might be anticipated from its pharmacological profile, tetrabenazine has the potential to cause tardive dyskinesia. " 05/01/2013 - "Tardive dyskinesia caused by tetrabenazine."
3.	Dyskinesias (Dyskinesia) 04/01/2017 - "Most patients were resistant to drug intervention, although tetrabenazine was effective in partially controlling dyskinesia for 2/7 patients. " 04/01/1972 - "Tetrabenazine is an effective agent for the suppression of choreiform and ballistic involuntary movements. " 04/01/2017 - "Tetrabenazine and DBS were the most useful treatments for dyskinesia." 01/01/2017 - "Tetrabenazine and subthalamic stimulation in graft-induced dyskinesias." 05/01/2013 - "Generalized choreiform dyskinesia developed after 10 months of conventional-dosage tetrabenazine treatment, persisting for several weeks after the drug was discontinued. "
4.	Hyperkinesis 01/01/2008 - "In clinical studies, tetrabenazine has been found to be effective in a wide range of hyperkinetic movement disorders, including small numbers (<50) of patients with TS in some studies. " 01/01/1982 - "In a double-blind crossover trial of tetrabenazine versus placebo, 19 patients with a variety of hyperkinetic movement disorders were evaluated. " 01/01/2020 - "Predictive factors for tolerability of tetrabenazine in patients with hyperkinetic movement disorders." 05/01/2017 - "Orodispersible films (ODF) were formulated to facilitate tetrabenazine (TBZ) administration to paediatric population for the treatment of hyperkinetic movement disorders. " 02/01/2017 - "Tetrabenazine (TBZ) is commonly used in hyperkinetic movement disorders. "
5.	Huntington Disease (Huntington's Disease) 01/01/2018 - "Physician perception versus true efficacy of tetrabenazine for Huntington's disease." 01/01/2012 - "Clinical assessment of the effect of tetrabenazine on functional scales in huntington disease: a pilot open label study." 06/01/2023 - "These findings proved, tetrabenazine as one of the potential therapeutic agent for treatment of Huntington's disease. " 11/01/2020 - "Tardive Syndrome Associated With Tetrabenazine in Huntington Disease: A Case Report." 01/01/2019 - "Author response: Evaluating depression and suicidality in tetrabenazine users with Huntington disease."

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	deutetrabenazine
3.	Trihexyphenidyl (Artane)
4.	Levodopa (L Dopa)
5.	Haloperidol (Haldol)
6.	Amantadine (Aman)
7.	Tiapride Hydrochloride
8.	Antipsychotic Agents (Antipsychotics)
9.	Botulinum Toxins (Botulinum Toxin)
10.	Clonidine (ST 155)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)
5.	Nerve Block (Nerve Blocks)