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Tetanus Toxin

Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Also Known As:
Tetanus Toxins; Neurotoxin, Clostridial; Toxin, Clostridium tetani; Toxin, Tetanus; Toxins, Tetanus; Clostridial Neurotoxin; Clostridium tetani Toxin
Networked: 397 relevant articles (12 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Stevenson, Freda K: 7 articles (09/2013 - 01/2005)
2. Jefferys, J G R: 4 articles (12/2014 - 01/2002)
3. Rice, Jason: 4 articles (09/2013 - 05/2005)
4. Kwok, William W: 4 articles (04/2010 - 09/2005)
5. Cook, Mark J: 3 articles (10/2015 - 01/2009)
6. Barbieri, Joseph T: 3 articles (10/2014 - 07/2008)
7. Ottensmeier, Christian H: 3 articles (08/2011 - 11/2009)
8. Finnerty, G T: 3 articles (12/2002 - 04/2000)
9. Halliday, Amy J: 2 articles (10/2015 - 01/2013)
10. Lai, Alan: 2 articles (10/2015 - 01/2009)

Related Diseases

1. Tetanus
2. Diphtheria
3. Seizures (Seizure)
4. Epilepsy (Aura)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Antibodies
2. Antigens
3. T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)
4. Carbamazepine (Tegretol)
5. etiracetam (levetiracetam)
6. Vaccines
7. Monoclonal Antibodies
8. Single-Chain Antibodies
9. Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)
10. Synthetic Vaccines (Recombinant Vaccines)

Related Therapies and Procedures

1. Microspheres (Microsphere)
2. Injections
3. Tenotomy
4. Microelectrodes
5. Intramuscular Injections