Testolactone (Teslac)

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44 relevant articles (11 outcomes, 6 trials/studies) found for this Drug

Description: An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.

Also Known As:

Teslac; 1-Dehydrotestolactone; Bristol-Myers Squibb Brand of Testolactone; delta(1)-Testolactone; 1 Dehydrotestolactone; Bristol Myers Squibb Brand of Testolactone; D-Homo-17a-oxaandrosta-1,4-diene-3,17-dione

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 58

1,2,4,5-tetrahydrotestolactone

4,5-dihydrotestolactone

1,2,4,5-tetrahydrotestolactone

4,5-dihydrotestolactone

Experts

1.	Kutlu, Alev Oguz: 1 article (01/2005)
2.	Kara, Cengiz: 1 article (01/2005)
3.	Apaydin, Sema: 1 article (01/2005)
4.	Tosun, Mahya Sultan: 1 article (01/2005)
5.	Senel, Ferda: 1 article (01/2005)
6.	Strain, Gladys W: 1 article (09/2003)
7.	Miller, Lorraine K: 1 article (09/2003)
8.	Zumoff, Barnett: 1 article (09/2003)
9.	Hill, S: 1 article (03/2000)
10.	Jones, J V: 1 article (03/2000)

Related Diseases

1.	Precocious Puberty 06/01/1997 - "Precocious puberty was treated initially with testolactone and later with oophorectomy" 01/01/2004 - "The first-generation agent, testolactone, has been demonstrated to be tolerable and effective in the treatment of familial male precocious puberty, while mixed results with testolactone have been achieved in girls with McCune-Albright syndrome" 10/30/1986 - "We conclude that testolactone is an effective treatment of precocious puberty in the McCune-Albright syndrome." 09/01/1993 - "Long-term testolactone therapy for precocious puberty in girls with the McCune-Albright syndrome." 06/01/1985 - "Testolactone may be an effective therapy of precocious puberty in girls with McCune-Albright syndrome." Get all the results and reference details, order at left...
2.	Polyostotic Fibrous Dysplasia (McCune Albright Syndrome) 03/01/1998 - "Girls with McCune-Albright syndrome, given testolactone, respond similarly" 06/01/1987 - "Short-term effects of testolactone compared to other treatment modalities on longitudinal growth and ovarian activity in a girl with McCune-Albright syndrome." 01/01/2004 - "The first-generation agent, testolactone, has been demonstrated to be tolerable and effective in the treatment of familial male precocious puberty, while mixed results with testolactone have been achieved in girls with McCune-Albright syndrome" 10/30/1986 - "We conclude that testolactone is an effective treatment of precocious puberty in the McCune-Albright syndrome." 09/01/1993 - "Long-term testolactone therapy for precocious puberty in girls with the McCune-Albright syndrome." Get all the results and reference details, order at left...
3.	Oligospermia (Oligozoospermia) 05/01/1981 - "These data suggest that Teslac may be an effective treatment for men with idiopathic oligospermia" 05/01/1989 - "Subjects (n = 25) with infertility due to unexplained oligozoospermia were given testolactone (2 g/day) or placebo for 8 months followed by crossover to the other treatment for an additional 8 months" 01/01/1988 - "Tamoxifen and testolactone in therapy of oligozoospermia: results of a randomized study." 07/01/1987 - "In a pilot study, 13 subfertile men with idiopathic normogonadotropic oligozoospermia were treated by the aromatase inhibitor testolactone for a period of 6 months" 07/01/1987 - "Long-term therapy of oligozoospermia with the aromatase inhibitor testolactone]" Get all the results and reference details, order at left...
4.	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/01/2004 - "A favorable outcome with the use of testolactone in conjunction with conventional therapy in children with congenital adrenal hyperplasia has also been suggested" 10/01/1996 - "A preliminary study of flutamide, testolactone, and reduced hydrocortisone dose in the treatment of congenital adrenal hyperplasia." 07/01/2002 - "A new four-drug treatment regimen of flutamide, testolactone, reduced hydrocortisone dose, and 9alpha-fludrocortisone has been shown to achieve normal growth and development after 2 yr of therapy and may, therefore, represent a potential alternative approach to the treatment of children with classic congenital adrenal hyperplasia" 03/01/2000 - "Flutamide, testolactone, and reduced hydrocortisone dose maintain normal growth velocity and bone maturation despite elevated androgen levels in children with congenital adrenal hyperplasia." 06/01/1999 - "In a 6-month pilot study of 12 children (eight boys; four girls) with congenital adrenal hyperplasia, testolactone, in combination with an antiandrogen (flutamide), a mineralocorticoid (fludrocortisone acetate, Florinef), and a reduced glucocorticoid dose, improved the control of growth and bone maturation compared with conventional therapy" Get all the results and reference details, order at left...
5.	Virilism (Virilization) 01/01/2005 - "Treatment of the proband was more effective with anastrozole than with testolactone and increased the initially reduced testes volume to normal size, promoted virilization, and normalized serum estrone and testosterone levels" 03/01/1998 - "A 2-yr-old female (case 1) on testolactone for non-McCune-Albright gonadotropin independent precocious puberty had marked elevations of androstenedione (18 ng/mL, normal: 0.2-3.1) and testosterone (3.6 ng/mL, normal < 0.2) but no virilization" Get all the results and reference details, order at left...
31 Diseases and 44 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Aromatase (CYP19)
2.	Testosterone (Sustanon)
3.	Estradiol (Estrace)
4.	anastrozole (Arimidex)
5.	Spironolactone (Aldactone)
6.	Flutamide (Eulexin)
7.	Gonadotropin-Releasing Hormone (GnRH)
8.	Fludrocortisone
9.	Estrogen Receptor Modulators (Antiestrogen)
10.	Estrone (Folliculin)
37 Drugs and Important Bio-Agents and 41 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Combination Drug Therapy (Combination Chemotherapy)
2 Therapies and Procedures and 2 more articles analyzed in the Research Interface, order at left...

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