Teratoma (Cystic Teratoma)

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1614 relevant articles (57 outcomes, 73 trials/studies) found for this Disease

Description: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They may be solid or cystic and are classified histologically as mature, immature, and malignant. (From Dorland, 27th ed & DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)

Also Known As:

Cystic Teratoma; Teratoid Tumor; Cystic Teratomas; Dysembryomas; Mature Teratoma; Mature Teratomas; Teratoid Tumors; Teratomas; Teratomas, Cystic; Teratomas, Mature; Tumor, Teratoid; Tumors, Teratoid; Dysembryoma; Teratoma, Cystic; Teratoma, Mature

Relationship Network

Disease Context: Research Results

Neoplasms: 387500

Neoplasms by Histologic Type: 1

Germ Cell and Embryonal Neoplasms: 2523

Teratoma: 1614

Struma Ovarii: 67

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Neoplasm Metastasis (Metastasis)
4.	Teratoma (Cystic Teratoma)
5.	Germinoma

Experts

1.	Motzer, Robert J: 5 articles (03/2007 - 10/2003)
2.	Sheinfeld, Joel: 5 articles (03/2007 - 10/2003)
3.	Bosl, George J: 5 articles (03/2007 - 10/2003)
4.	Dalmau, J: 2 articles (09/2008 - 01/2008)
5.	Sheikh, Ahmad Y: 2 articles (12/2007 - 05/2007)
6.	Robbins, Robert C: 2 articles (12/2007 - 05/2007)
7.	Carver, Brett S: 2 articles (03/2007 - 07/2006)
8.	Shayegan, Bobby: 2 articles (03/2007 - 07/2006)
9.	Koide, Reiji: 2 articles (01/2007 - 01/2007)
10.	Dalmau, Josep: 2 articles (01/2007 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Teratoma:

1.	alpha-Fetoproteins (AFP)IBA 07/01/2004 - "Although perinatal teratomas have a relatively low recurrence rate of 5%, close follow-up with imaging studies and serum alpha-fetoprotein determinations is is strongly recommended" 11/15/1993 - "Imaging studies suggested an intrahepatic teratoma, but serum alpha-fetoprotein levels were extremely elevated" 12/01/1990 - "Histological analysis revealed a malignant teratoma, also with alpha-fetoprotein-positive elements in the immunohistochemical study." 07/01/2008 - "The favourable prognostic factors assessed by univariate analysis were elevation of alpha-fetoprotein alone, complete resection of residual disease, histological finding of differentiated teratoma in the resected tissues and normalization of tumour markers after pcRPLND" 06/01/2008 - "In the case of neonatal mature teratoma, the L3 fraction was below 0.5%, even when the total AFP level was high" Order ALL the reference details at left...
2.	Cisplatin (Platino)FDA LinkGeneric 09/15/1993 - "Among the eight patients with immature teratomas, five were treated before the advent of cisplatin treatment (two children younger than 15 years were cured by surgery alone and three adults died within 7 months after operation)" 03/01/2002 - "Histological examination showed that 5 weeks after injecting cisplatin (3 mg/kg/week), primitive mesenchymal-like cells increased, and 10 weeks afterward cartilage and well-developed glands (teratoma) were apparent; at > 15 weeks afterward there were no EC cells visible" 01/01/1997 - "We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma" 06/01/1994 - "Mechanisms of cisplatin resistance have been studied in two independently-selected sublines expressing clinically-relevant levels of resistance (3-fold) and established from a primary testicular teratoma obtained from previously untreated patients" 07/01/1990 - "In vitro exposure of a human testicular teratoma continuous cell line to fractionated X-irradiation resulted in the expression of resistance to cisplatin" Order ALL the reference details at left...
3.	Biological Tumor Markers (Tumor Markers)IBA 01/01/2006 - "The objective of this study was to evaluate size, bilaterality, histopathologic origin, and the serum levels of some tumor markers in patients with mature cystic teratomas (MCTs) of the ovary" 03/01/2008 - "In conclusion neither imaging analysis nor tumor markers including SCC and CEA accurately diagnose malignant transformation of mature cystic teratoma in its early stage, suggesting that a combination of diagnostic means is important" 08/01/2006 - "One biopsy revealed only mature teratoma, an inconclusive result since the patient's serum and CSF tumor markers were elevated" 04/01/2000 - "Transvaginal ultrasonography, magnetic resonance imaging, and serum concentrations of tumor markers led to a diagnosis of a mature cystic teratoma" 02/01/2000 - "RESULTS: In all patients with teratoma, tumor markers were normal" Order ALL the reference details at left...
4.	InterferonsIBA 09/01/1995 - "Remission of recurrent mature teratoma with interferon therapy." 01/01/2004 - "As removal of the teratoma was technically unfeasible, the patient was started on interferon alpha2beta, 3 MU/day, 5 days per week" 09/01/1995 - "Although alpha-interferons have anti-tumour activity in a variety of solid and haematological malignancies, they are not generally considered to be effective therapy for mature testicular teratomas" 11/01/1984 - "Response of differentiated but not anaplastic teratoma to interferon." 01/01/1983 - "Factors acting upon differentiation of mouse teratoma in vivo: spontaneous differentiation and effects of interferon." Order ALL the reference details at left...
5.	Etoposide (VP 16)FDA LinkGeneric 06/01/2000 - "In conclusion, etoposide decreased the immature tissue components of teratomas, while mature tissues remained unaffected" 06/01/2000 - "The etoposide-treated 4-week teratomas, but not the 6-week teratomas, were significantly smaller than those in the corresponding control groups" 06/01/2000 - "Effect of etoposide on experimental testicular teratoma in 129/SvJ mice." 04/15/1994 - "Mechanisms of resistance to VP-16 were monitored in a series of sublines of the human testicular teratoma cell line (SuSa) derived following exposure either to fractionated X-irradiation (DXR-10) or to VP-16 using pulsed 24-hr exposures (VP10) or continuous exposure conditions (VPC2, VPC3 and VPC4)" 04/15/1994 - "Multiple mechanisms of resistance in a series of human testicular teratoma cell lines selected for increasing resistance to etoposide." Order ALL the reference details at left...
6.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 08/17/1985 - "In 1 patient with testicular teratoma and elevated human chorionic gonadotropin who had a normal computed tomography scan, the labelled antibody located microscopic disease in a lymph node, which was then removed" 05/01/1975 - "Mediastinal teratoma with chorionic gonadotropin secretion]" 02/01/1966 - "Malignant teratoid tumors of the testis with excretion of chorionic gonadotropin with special emphasis on the toad test; case reports]" 03/01/2006 - "An autopsy case of primary mixed choriocarcinoma and mature teratoma located in the thymic region associated with elevated human chorionic gonadotropin levels and characteristic testicular changes." 04/01/1991 - "Sexual precocity regressed and human chorionic gonadotropin levels in the serum and cerebrospinal fluid fell to normal after surgery, suggesting that the precocious puberty was secondary to ectopic human chorionic gonadotropin production by the pineal teratoma." Order ALL the reference details at left...
7.	squamous cell carcinoma-related antigenIBA 05/15/2000 - "Transvaginal color Doppler ultrasonic characterization of benign and malignant ovarian cystic teratomas and comparison with serum squamous cell carcinoma antigen." 12/01/1995 - "The role of serum squamous cell carcinoma antigen in detecting degeneration of mature cystic teratomas at an early stage is considered." 06/01/1997 - "The preoperative squamous cell carcinoma antigen level was significantly higher in the patients with squamous cell carcinoma arising from mature cystic teratoma than in patients with mature cystic teratoma (P < .0001)" 07/01/1995 - "We attempted to assess the clinical utility of squamous cell carcinoma antigen (SCC) for detecting squamous cell carcinoma arising in mature cystic teratoma of the ovary" 07/01/1995 - "Clinical evaluation of squamous cell carcinoma antigen in squamous cell carcinoma arising in mature cystic teratoma of the ovary." Order ALL the reference details at left...
8.	Interferon-alpha (Interferon Alfa)FDA Link 09/01/1995 - "We report a case of complete remission in a patient with recurrent mature teratoma following treatment with alpha-interferon." 11/01/1984 - "A Phase 2 trial was conducted using intramuscular lymphoblastoid interferon (IFN, Wellcome Research Laboratories), 4 MU per day, in 10 patients with chemotherapy-resistant teratomas" 01/01/1991 - "This is a report on a patient with an unresectable growing mature teratoma in whom a long-lasting disease stabilization was achieved after treatment with lymphoblastoid interferon." 01/01/2004 - "Growing Teratoma syndrome treated by interferon alpha-2beta: case report and literature review." 01/01/1991 - "Growing teratoma syndrome successfully treated with lymphoblastoid interferon." Order ALL the reference details at left...
9.	Macrophage Colony-Stimulating FactorIBA 06/01/2000 - "This positive incidence of the elevated serum M-CSF levels was significantly higher compared with that (13.5%, 18/133) observed in patients with benign cystic teratoma of the ovary (P < 0.0001)" 01/01/1998 - "Only 7 (11%) of 64 patients with mature benign cystic teratoma had elevated levels of M-CSF" 06/01/2000 - "There was no correlation between the serum levels of M-CSF and SCC among patients with squamous cell carcinoma arising in mature cystic teratoma of the ovary" 06/01/2000 - "RESULTS: In 22 of the 31 (71.0%) patients with squamous cell carcinoma arising in mature cystic teratoma of the ovary, the serum M-CSF levels exceeded the upper limit of the normal level (1056 U/ml)" 06/01/2000 - "METHODS: Serum levels of M-CSF and SCC were assayed using blood samples collected preoperatively from 31 patients with squamous cell carcinoma arising in mature cystic teratoma of the ovary and 133 patients with mature cystic teratoma of the ovary without malignant transformation" Order ALL the reference details at left...
10.	PlatinumIBA 02/06/1976 - "cis-Diamino-dichloro-platinum (II) in the treatment of otherwise treatment-resistant malignant testicular teratoma (author's transl)]" 07/01/2008 - "However, there was no significant difference in sensitivity to platinum drugs between the primary teratoma and the peritoneal adenocarcinoma cells" 10/01/2007 - "Teratomas with malignant transformation occur in approximately 3 to 6% of patients with metastatic germ cell tumors treated with platinum-based chemotherapy" 01/01/2006 - "Teratomas with malignant transformation occur in a small proportion of patients with metastatic germ cell tumors treated with platinum-based chemotherapy" 01/01/2008 - "Relapse rates for stage IA nondysgerminomatous tumors and dysgerminomas were 8 of 22 (36%) and 2 of 9 (22%), respectively, plus one patient with mature teratoma and glial implants also relapsed; 10 of these 11 patients (91%) were successfully cured with platinum-based chemotherapy" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/1994 - "CONCLUSIONS: This study demonstrates that there is a group of patients with relapsed teratoma who can be cured without the need for very high dose chemotherapy and autologous bone marrow rescue." 08/01/2000 - "our opinion, a higher dose of radiotherapy in cases in which chemotherapy does not achieve a radiological complete remission is not advisable, because very often the residual radiological abnormality does not represent biologically active tumour but differentiated forms such as mature teratoma" 07/01/1999 - "One patient who underwent complete resection of a mediastinal malignant teratoma combined, received PVB chemotherapy on an adjuvant basis and remains alive and disease-free" 01/01/1992 - "Excepting in situations of great urgency surgery usually follows chemotherapy and is used as follows: in patients who appear to be in complete remission but who have residual lesions which require eradication, and those with malignant tissue which is persisting or more often of a mature teratoma which may have a risk of progressing" 03/01/1991 - "Case 2. A 30-year-old patient with testicular teratoma, stage IIIA, on the right side gained complete remission after a CDDP containing chemotherapy" Order ALL the reference details at left...
2.	Orchiectomy (Orchidectomy) 01/01/1984 - "Prognosis is best in teratoma which is cured by orchiectomy" 07/01/2002 - "Patients with mature (40 pts.) and immature (19 pts.) teratoma were cured by orchiectomy alone" 01/01/1993 - "One patient had surgical excision of a mature teratoma in the ipsilateral iliac region 26 months after orchiectomy and is now disease-free without further treatment after 25+ months" 04/01/2008 - "DIAGNOSIS: A 1.7 cm nodule anterior to the right psoas muscle suspicious for metastatic disease that was seen on CT 16 months after orchiectomy was pathologically confirmed as recurrent mature teratoma in the spermatic cord" 11/01/2006 - "In one infant, a testicular tumour was found sonographically, and orchiectomy confirmed diagnosis of a teratoma" Order ALL the reference details at left...
3.	Adjuvant Chemotherapy 04/03/1993 - "The first case concerned an 8-year old girl who had a teratoma; she was treated by surgery and adjuvant chemotherapy; 4 years after the diagnosis she is still alive and in complete remission" 07/01/1998 - "COMMENTS: It is suggested that an international randomized trial for patients with incompletely resected high risk teratoma be initiated to evaluate the effect of adjuvant chemotherapy on specific end-points: 1) influence on relapse rate in general; 2) reduction of the proportion of malignant relapses; 3) avoidance of mutilating surgery." 07/01/2008 - "Therefore, it is likely that adjuvant chemotherapy lowers the risk of ovarian immature teratomas recurring after optimal surgery" 10/01/2007 - "The only exceptions are stage 1, grade 1, immature teratoma and stage 1A dysgerminoima who are followed up after surgery without adjuvant chemotherapy" 11/01/2006 - "In reviewing the literature on the subject, the role of neoadjuvant and adjuvant chemotherapy remains ill-defined for the immature teratoma" Order ALL the reference details at left...
4.	Lymph Node Excision (Lymph Node Dissection) 11/01/2008 - "The retroperitoneal lymph node dissection (RPLND) has been shown to prolong survival for patients with chemorefractory ovarian immature teratoma" 05/01/2007 - "Teratoma is frequently found associated with other nonseminomatous histologies and is present in the retroperitoneum in 40% of postchemotherapy retroperitoneal lymph node dissections" 03/20/2007 - "PURPOSE: The histologic finding of teratoma occurs in approximately 40% of all postchemotherapy retroperitoneal lymph node dissections (PC-RPLND)" 03/20/2007 - "Long-term clinical outcome after postchemotherapy retroperitoneal lymph node dissection in men with residual teratoma." 05/01/2006 - "One patient from group 1 required subsequent retroperitoneal lymph node dissection for recurrent mature teratoma" Order ALL the reference details at left...
5.	Transplantation (Transplant Recipients) 08/22/2008 - "Immunohistochemical studies of the grafted area one year post transplantation revealed that transplanted hESC derived neural precursor cells survived, integrated in vivo and differentiated into dopaminergic neurons without teratoma formation" 03/15/2005 - "A transplantation study showed that the enriched ES-cell-derived hepatocytes integrated into the injured mouse liver and produced no teratomas" 11/20/2008 - "Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice" 11/01/2008 - "We anticipate that novel pluripotent-specific reporter vectors will select for isolation of high quality human iPS cell lines, and select against undifferentiated pluripotent cells during regenerative medicine to prevent teratoma formation after transplantation." 10/01/2008 - "At 1 month of therapy, transplantation of 200,000 cells per heart achieved teratoma-free reversal of systolic dysfunction and electrical synchronization and halted maladaptive remodeling, thereby preventing end-stage organ failure" Order ALL the reference details at left...

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