Triethylenephosphoramide (TEPA)

01/01/2015 - "These findings suggest that APRPG-TEPA-PCL/si-mTOR is useful for the treatment of PTEN-positive tumors."
01/01/2020 - "Data on feasibility and effect size of TEPA will be analyzed upon completion of Phase II, allowing us to design a large, adequately powered RCT to verify the effectiveness of this intervention on CRF management in patients with hematologic cancer. "
01/19/2016 - "Taken together, our present data indicate that miR-499 delivered with APRPG-modified-TEPA-PCL normalized tumor vessels, resulting in enhancement of intratumoral accumulation of DOX. "
07/15/2015 - "In EMT6 xenograft mouse models, TEPA administration inhibited the tumor growth and increased mice survival. "
01/01/2013 - "These results suggest that miR-92a-C/TEPA-PCL is promising for the treatment of tumors via the suppression of angiogenesis."

01/01/1969 - "On the other hand, tepa was found to be very effective in inducing lasting sterility throughout the 6 successive matings. "
09/01/1976 - "The sterility of the queens of the pharaoh's ant was increased at a relation of 1 part of Tepa to 5 parts of Piperonylbutoxide up to twentyfold. "
06/01/1971 - "Sterility and the mated status test in tepa-treated male sheep blow-flies, Lucilia sericata (Mg.) (Dipt., Calliphoridae)."
08/01/1980 - "A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. "
06/01/1971 - "Sterility and semisterility in male progeny of male mice treated with the chemical mutagen TEPA."

07/15/2015 - "These results indicate that TEPA inhibits CoCl2-induced EMT most likely via HIF1-α-Snail/Twist signaling pathway, and copper depletion may be exploited as a therapeutic for breast cancer. "
11/01/2015 - "Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy."
07/15/2015 - "Using CoCl2-induced EMT of human breast carcinoma MCF-7 cells, we found that TEPA, a copper chelator, inhibited EMT-like cell morphology and cytoskeleton arrangement triggered by CoCl2; decreased the expression of vimentin and fibronectin, markers typical of EMT; inhibited HIF-1 activation and HIF1-α accumulation in nuclear; and down-regulated the expression of hypoxia-associated transcription factors, Snail and Twist1. "

01/01/2013 - "The aim of this work was to study dynamics of new cases of hospital thromboembolism of pulmonary artery branches (TEPA) based on the registry data of Tomsk hospitals for 2003-2010 and to estimate applicability of recommendations of European Society of Cardiologists (2008) on diagnostics and treatment of TEPA. "
01/01/2013 - "The number of new cases of submassive TEPA and TEPA of small branches with the fatal outcome decreased to 40.7 and 48% since 2007 while the incidence of lethal massive thromboembolism amounted to 68%. "
01/01/2005 - "Recurrent pulmonary artery thromboembolism (TEPA) prevailed in APS patients. "
01/01/2000 - "Pathologo-morphological and clinical records of 803 surgical patients have been analysed, in whom the thromboembolism of pulmonary artery (TEPA) was the only or the main cause of the death. "
01/01/1995 - "Initial or relapsing thromboembolism of the pulmonary artery (TEPA) had place in 5 cases. "

01/01/2011 - "Our study was concerned with the role of ultrasound examination of the lower extremity veins to detect deep venous thrombosis and to evaluate complex prophylaxis of thromboembolism of pulmonary arteries (TEPA). "
01/01/2011 - "Up to 75% of the cases of venous thrombosis in the lower extremities are associated with latent TEPA and 80% of the cases of pulmonory embolism with asymptomatic venous thrombosis. "
01/01/2011 - "This condition is currently regarded as a continuum of thromboembolism of pulmonary artery (TEPA) and venous thromboses including superficial venous thromboses. "
03/01/2003 - "In 65 patients an acute venous thrombosis was complicated by thromboembolism of pulmonary artery (TEPA), 2 patients died before initiation of treatment. "
01/01/2005 - "Risk factors of the development of phlebothrombosis and thromboembolism of the pulmonary artery (TEPA) were estimated in 257 patients as associated both with the patient and the trauma. "