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Teniposide (VM 26)

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Also Known As:
VM 26; Vumon; NSC-122819; Teniposide, (5a alpha,9 alpha(S*))-Isomer; VM-26; NSC 122819; NSC122819; VM26; Demethyl Epipodophyllotoxin Thenylidine Glucoside; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Networked: 573 relevant articles (53 outcomes, 135 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Xu, Qin: 4 articles (06/2005 - 11/2002)
2. Tang, Ya-Jie: 3 articles (06/2021 - 01/2020)
3. Zhao, Wei: 3 articles (06/2021 - 01/2020)
4. Chen, Yuanli: 3 articles (12/2018 - 06/2013)
5. Duan, Yajun: 3 articles (12/2018 - 06/2013)
6. Han, Jihong: 3 articles (12/2018 - 06/2013)
7. Steinbach, Joachim P: 3 articles (01/2016 - 09/2002)
8. Devidas, Meenakshi: 3 articles (07/2014 - 02/2006)
9. Chen, Wan-tao: 3 articles (06/2005 - 11/2003)
10. Guo, Wei: 3 articles (05/2004 - 11/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
3. Leukemia
4. Neuroblastoma
5. Small Cell Lung Carcinoma (Small Cell Lung Cancer)

Related Drugs and Biologics

1. Teniposide (VM 26)
2. Cytarabine (Cytosar-U)
3. Cisplatin (Platino)
4. Doxorubicin (Adriamycin)
5. Etoposide (VP 16)
6. Vincristine (Oncovin)
7. Cyclophosphamide (Cytoxan)
8. Methotrexate (Mexate)
9. Carboplatin (JM8)
10. Thiotepa (Triethylenethiophosphoramide)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Radiotherapy
4. Induction Chemotherapy
5. Intravesical Administration