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Hereditary Hemorrhagic Telangiectasia

An autosomal dominant vascular anomaly characterized by telangiectases of the skin and mucous membranes and by recurrent gastrointestinal bleeding. This disorder is caused by mutations of a gene (on chromosome 9q3) which encodes endoglin, a membrane glycoprotein that binds TRANSFORMING GROWTH FACTOR BETA.
Also Known As:
Telangiectasia, Hereditary Hemorrhagic; Osler-Rendu-Weber Disease; Osler-Weber-Rendu Syndrome; Hemorrhagic Telangiectasia, Hereditary; Osler Rendu Disease; Osler Rendu Weber Disease; Osler Weber Rendu Syndrome; Osler-Rendu Disease
Networked: 373 relevant articles (18 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Epistaxis (Nosebleed)
2. Hemorrhage
3. Vascular Malformations
4. Gastric Antral Vascular Ectasia (Watermelon Stomach)
5. Vasculitis (Vasculitides)

Experts

1. Bernabeu, Carmelo: 11 articles (09/2013 - 08/2005)
2. Dupuis-Girod, Sophie: 8 articles (02/2015 - 03/2010)
3. Bailly, Sabine: 7 articles (02/2015 - 03/2007)
4. Letarte, Michelle: 7 articles (01/2015 - 03/2005)
5. Faughnan, Marie E: 7 articles (01/2015 - 11/2003)
6. Oh, S Paul: 7 articles (10/2014 - 07/2007)
7. Botella, Luisa M: 7 articles (09/2013 - 03/2006)
8. Sadick, Haneen: 7 articles (01/2009 - 03/2002)
9. Riedel, Frank: 7 articles (01/2009 - 03/2002)
10. Bayrak-Toydemir, Pinar: 6 articles (09/2015 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Hemorrhagic Telangiectasia:
1. bevacizumabFDA Link
2. Tranexamic Acid (AMCA)FDA Link
3. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
4. Thalidomide (Thalomid)FDA Link
5. Blue rubber bleb nevus syndromeIBA
6. Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
7. Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
8. Interleukin-6 (Interleukin 6)IBA
9. Interleukin-5 (Interleukin 5)IBA
10. Interleukin-1 (Interleukin 1)IBA

Therapies and Procedures

1. Aftercare (After-Treatment)
2. Transplants (Transplant)
3. Therapeutic Embolization
4. Argon Plasma Coagulation
5. Off-Label Use