Taurolithocholic Acid

A bile salt formed in the liver from lithocholic acid conjugation with taurine, usually as the sodium salt. It solubilizes fats for absorption and is itself absorbed. It is a cholagogue and choleretic.

Also Known As:

Taurolithocholic Acid, Monosodium Salt; Acid, Taurolithocholic; Lithocholate, Taurine; Lithocholyltaurine; Taurine Lithocholate; Taurolithocholate; Ethanesulfonic acid, 2-(((3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl)amino)-

Networked: 80 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Criddle, David N: 4 articles (01/2020 - 01/2014)
2.	Sutton, Robert: 4 articles (01/2020 - 01/2014)
3.	Awais, Muhammad: 3 articles (01/2020 - 01/2018)
4.	Chvanov, Michael: 3 articles (01/2020 - 01/2018)
5.	Tepikin, Alexei V: 3 articles (01/2020 - 01/2018)
6.	Voronina, Svetlana: 3 articles (01/2020 - 01/2018)
7.	Coleman, R: 3 articles (08/2003 - 02/2001)
8.	Milkiewicz, P: 3 articles (08/2003 - 02/2001)
9.	Roma, M G: 3 articles (08/2003 - 02/2001)
10.	De Faveri, Francesca: 2 articles (01/2020 - 01/2018)

Related Diseases

1.	Cholestasis 01/01/1988 - "The purpose of this study was to examine the effects of taurolithocholate-induced cholestasis on in vivo conjugation. " 12/01/1987 - "In a previous study, MIBK was shown to potentiate the cholestasis induced by taurolithocholate in rats. " 01/01/1987 - "To further study this effect, we tested whether endotoxin tolerance could ameliorate the adverse effects of taurolithocholate (TLCA) which causes cholestasis by altering liver plasma membrane organization. " 09/01/1975 - "Studies of the effect of taurolithocholate and other models of cholestasis." 12/01/2017 - "Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). "
2.	Inflammation (Inflammations) 01/01/2018 - "Increased key BAs were associated with higher grades of steatosis (taurocholate), lobular (glycocholate) and portal inflammation (taurolithocholate), and hepatocyte ballooning (taurocholate). " 01/01/2022 - "Since bile acids regulate lipid metabolism and in some cases reduce inflammation, our second objective was to investigate whether myelin clearance could be improved with taurolithocholic acid (TLCA), tauroursodeoxycholic acid or hyodeoxycholic acid. "
3.	Pancreatitis 05/01/2012 - "The present study aims to determine the differentially expressed proteins in taurolithocholic acid 3-sulfate-stimulated pancreatic acinar cells as an in vitro model for acute pancreatitis. " 01/01/2018 - "An inducer of acute pancreatitis taurolithocholic acid 3-sulphate and supramaximal concentrations of cholecystokinin triggered the formation of giant (more than 2.5 μm in diameter) endocytic vacuoles. " 07/01/2011 - "Pretreatment with IRS954 reduced pancreatic necrosis and lung inflammation in taurolithocholic acid 3-sulfate-induced acute pancreatitis. " 01/01/2014 - "Acute pancreatitis was induced in mice either by the retrograde infusion of taurolithocholic acid sulfate into the pancreatic duct or by intraperitoneal injections of cerulein (50 μg/kg per hour). " 12/01/2022 - "These organelles develop in acinar cells exposed to several inducers of acute pancreatitis (including taurolithocholic acid and high concentrations of secretagogues cholecystokinin and acetylcholine). "
4.	Neoplasms (Cancer) 08/19/2022 - "Several recent studies have demonstrated that TGR5 exerts inconsistent effects in different cancer cells upon activating via TGR5 agonists, such as INT-777, ursodeoxycholic acid (UDCA), and taurolithocholic acid (TLCA). " 08/25/2020 - "The lactoferrin + linolenic acid combination inhibited phosphorylation in the JAK2/STAT3-related pathway by downregulating the special metabolite lithocholyltaurine, thereby suppressing formation of KYSE450 tumors." 08/25/2020 - "The Combination of Two Bioactive Constituents, Lactoferrin and Linolenic Acid, Inhibits Mouse Xenograft Esophageal Tumor Growth by Downregulating Lithocholyltaurine and Inhibiting the JAK2/STAT3-Related Pathway." 01/01/1987 - "The present results suggest that six bile acids, but not taurolithocholic acid sodium salt, have potential tumor-promoting activities in the pyloric mucosa of rat stomach and that glycocholic acid sodium salt has no potential tumor-initiating activity in the pyloric mucosa of rat stomach."
5.	Body Weight (Weight, Body) 08/01/2003 - "In vivo pharmacokinetic studies revealed that taurolithocholate (3 micro mol/100 g body weight) diminished by 58% canalicular excretion and increased by 96% plasma reflux of (14)C taurocholate. " 01/01/1988 - "A 30-mg/kg bolus of acetaminophen was administered intravenously to rats 2 hr (acute cholestasis) or 20 hr (postcholestasis) after intravenous pretreatment with sodium taurolithocholate, 5 mumol/100 g body weight. " 03/01/1977 - "Cholestasis or choleresis was induced in the rat by intravenous infusion (0.05 to 0.2 mumole per minute per 100 grams of body weight) of sodium taurolithocholate, 3beta-hydroxy-5-cholenoate, taurocholate, and dehydrocholate either singly or in combination after or without cannulation of the common bile duct. "

Related Drugs and Biologics

1.	ursodoxicoltaurine
2.	Taurocholic Acid (Sodium Taurocholate)
3.	Bile Acids and Salts (Bile Acids)
4.	Taurochenodeoxycholic Acid
5.	Sulfhydryl Compounds (Thiols)
6.	Protein Kinase C
7.	hyodeoxycholic acid
8.	Bilirubin
9.	Manganese
10.	Lithocholic Acid

Related Therapies and Procedures

1.	Ligation
2.	Intravenous Injections
3.	Intraperitoneal Injections
4.	Intravenous Infusions
5.	Aftercare (After-Treatment)