Taurochenodeoxycholic Acid

A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.

Also Known As:

Networked: 76 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Peifeng: 4 articles (01/2021 - 12/2011)
2.	Mao, Wei: 3 articles (01/2021 - 12/2011)
3.	Li, Lei: 3 articles (12/2019 - 12/2011)
4.	Freedman, Neal D: 2 articles (01/2022 - 01/2022)
5.	Liu, Chang: 2 articles (12/2019 - 04/2013)
6.	Huang, Fengjie: 2 articles (10/2016 - 04/2016)
7.	Jia, Wei: 2 articles (10/2016 - 04/2016)
8.	Liu, Ping: 2 articles (10/2016 - 04/2016)
9.	Wang, Xiaoning: 2 articles (10/2016 - 04/2016)
10.	Xie, Guoxiang: 2 articles (10/2016 - 04/2016)

Related Diseases

1.	Cholestasis 12/01/2021 - "In PFBS-exposed livers, high levels of bile acid metabolites (e.g., taurochenodeoxycholic acid) accumulated, implying the induction of cholestasis. " 07/28/2008 - "Infusion of Taurochenodeoxycholate (TCDCA) represents a model of bile salt-induced cholestasis in rat. " 07/01/2005 - "Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers." 02/01/1998 - "Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat." 03/01/1996 - "Estradiol-17beta-D-glucuronide interacts with MDR1, and taurochenodeoxycholic acid and lithocholate-3-O-glucuronide may interact with vesicular transport system, each of which may relate with the genesis of cholestasis. "
2.	Inflammation (Inflammations) 01/01/2021 - "Transcriptome investigation of anti-inflammation and immuno-regulation mechanism of taurochenodeoxycholic acid." 05/01/1997 - "Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation." 01/01/2023 - "The plasma metabolomic profile further revealed that dietary SBM can alter inflammation-linked metabolites such as itaconic acid, taurochenodeoxycholic acid and enriched the arginine biosynthesis pathway. " 01/01/2021 - "total bile acids, +5.409 ± 1.834 μM, P = 0.026) and were strongly correlated to systemic inflammation (taurochenodeoxycholic acid and C-reactive protein: ρ = 0.36, Padj = 0.017). " 05/01/1997 - "Taurochenodeoxycholic acid (TCDCA) significantly normalized the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation. "
3.	Colitis 01/01/2023 - "Cotreatment also improved the diversity of the gut microbiome and rescued the concentration of taurochenodeoxycholic acid (TCDCA) in colitis. "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "Taurochenodeoxycholic acid inhibits the proliferation and invasion of gastric cancer and induces its apoptosis." 01/01/2022 - "PRACTICAL APPLICATIONS: Through this study, the inhibitory effect of Taurochenodeoxycholic acid on gastric cancer can be clarified, which provides a new research basis for the application of traditional Chinese medicine (TCM) and TCM monomer in cancer. "
5.	Pulmonary Fibrosis (Fibrosing Alveolitis) 07/01/2013 - "The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice." 07/01/2013 - "The present study prepared the pulmonary fibrosis model in mice by using Bleomycin and carry out the investigations on the effects of taurochenodeoxycholic acid (TCDCA) in preventing pulmonary fibrosis in mice. "

Related Drugs and Biologics

1.	Ursodeoxycholic Acid (Urso)
2.	Taurocholic Acid (Sodium Taurocholate)
3.	Taurolithocholic Acid
4.	Sulfhydryl Compounds (Thiols)
5.	Bile Acids and Salts (Bile Acids)
6.	ursodoxicoltaurine
7.	Indomethacin (Indometacin)
8.	Bleomycin (Blenoxane)
9.	Glycocholic Acid
10.	Taurodeoxycholic Acid

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Intravenous Infusions