Talc

Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed)

Also Known As:

Networked: 1273 relevant articles (79 outcomes, 178 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Cramer, Daniel W: 13 articles (06/2022 - 05/2005)
2.	Lee, Y C Gary: 13 articles (10/2018 - 12/2003)
3.	Maskell, Nick A: 12 articles (12/2020 - 12/2003)
4.	Rahman, Najib M: 11 articles (01/2020 - 06/2012)
5.	Light, R W: 11 articles (08/2003 - 01/2000)
6.	Marchi, Evaldo: 10 articles (10/2020 - 12/2002)
7.	Vargas, Francisco S: 9 articles (11/2009 - 12/2002)
8.	Marsh, Gary M: 8 articles (01/2022 - 01/2017)
9.	Miller, Robert F: 8 articles (01/2020 - 06/2012)
10.	Bhatnagar, Rahul: 7 articles (12/2020 - 02/2015)

Related Diseases

1.	Malignant Pleural Effusion 12/01/2006 - "Our study confirms that intrapleural talc carries good results in the treatment of malignant pleural effusion. " 04/01/2007 - "The present study evaluated the angiogenic balance in the pleural space in patients with malignant pleural effusions (MPE) following talc insufflation. " 12/01/1996 - "We designed a prospective, randomized study to compare video-assisted thoracoscopic talc insufflation with bedside talc slurry in the treatment of malignant pleural effusion. " 05/04/2021 - "Complications of thoracoscopic talc insufflation for the treatment of malignant pleural effusions: a meta-analysis." 01/01/2020 - "Instillation of sterile graded talc in the pleural space is performed to prevent reaccumulation of malignant pleural effusion after drainage. "
2.	Pneumothorax 10/01/1994 - "We conclude from these observations that the insufflation of 2 g of talc into the pleural space is a safe effective treatment for control of recurrent spontaneous pneumothorax." 11/01/2004 - "Feasibility, safety and efficacy of VATS for management of recurrent primary spontaneous pneumothorax following thoracoscopic talc poudrage are strongly suggested." 07/01/2012 - "The aim of this study was to compare talc poudrage and pleural abrasion in the treatment of spontaneous pneumothorax. " 10/01/2023 - "There was one case of recurrent ipsilateral pneumothorax in a patient who had no inflammatory response to talc insufflation. " 01/01/2020 - "During a median follow-up period of 70.0 months (95% confidence interval 66.6-73.4), pneumothorax recurred in 79 patients (9.4%); among these, 29 underwent redo surgery; 34, chest drain/talc slurry; and 16, clinicoradiological observation. "
3.	Pleural Effusion (Pleural Effusions) 07/01/2016 - "Talc administration caused a significant reduction in pleural effusion with no increase of pleural adhesion. " 07/01/1995 - "Recent study results indicate that intrapleural instillation of iodized talc is an adequate and effective treatment for control of neoplastic or benign pleural effusion." 06/01/1995 - "The intrapleural insufflation of talc was effective in preventing recurrence of pleural effusion. " 05/01/1992 - "These observations indicate that intrapleural instillation of a slurry of iodized talc is a safe, adequate, and effective treatment for control of neoplastic or benign pleural effusions." 12/01/2011 - "Not more effective than talc in preventing recurrent pleural effusions, based on a review with meta-analysis of 7 trials in 256 patients. "
4.	Neoplasms (Cancer) 01/01/2023 - "The literature search and selection process identified 40 primary studies that assessed exposure to talc and female reproductive cancer risks in humans (n = 36) and animals (n = 4). " 05/04/2021 - "Literature search was conducted in electronic databases and studies were selected if they reported complication rates of thoracoscopic talc insufflation in cancer patients with MPEs. " 01/01/2020 - "In addition, one would need to ignore the evidence from animal experiments that show no marked association with cancer, in vitro and genotoxicity studies that did not indicate a carcinogenic mechanism of action for talc, and mechanistic and transport investigations that did not support the retrograde transport of talc to the ovaries. " 11/01/2019 - "This study provides further evidence that excess deaths among Vermont talc workers are due largely to excess mortality from NMRD; there is no evidence of increased risk of respiratory cancer." 09/01/2017 - "This study updates information on mortality and cancer morbidity in a cohort of Norwegian talc workers. "
5.	Dyspnea (Shortness of Breath) 06/13/2012 - "There was a statistically significant improvement in dyspnea in the IPC group at 6 months, with a mean difference in VAS score between the IPC group and the talc group of −14.0 mm (95% CI, −25.2 to −2.8 mm; P = .01). " 06/13/2012 - "Dyspnea improved in both groups, with no significant difference in the first 42 days with a mean VAS dyspnea score of 24.7 in the IPC group (95% CI, 19.3-30.1 mm) and 24.4 mm (95% CI, 19.4-29.4 mm) in the talc group, with a difference of 0.16 mm (95% CI, −6.82 to 7.15; P = .96). " 10/01/1995 - "Although her shortness of breath was relieved following VAT decortication and talc insufflation, at 3 months she was found to have a 2.5-cm subcutaneous nodule at the camera port site which on biopsy was confirmed to be metastatic in nature. " 01/01/2020 - "Patient-reported control of breathlessness Pair-wise meta-analysis suggests there is likely no difference in breathlessness control, relative to talc slurry, of talc poudrage ((mean difference (MD) 4.00 mm, 95% CI -6.26 to 14.26) on a 100 mm visual analogue scale for breathlessness; studies = 1; participants = 184; moderate certainty) and IPCs without daily drainage (MD -6.12 mm, 95% CI -16.32 to 4.08; studies = 2; participants = 160; low certainty). " 04/19/2010 - "Video-assisted thoracoscopic talc poudrage is an effective and safe procedure that yields a high rate of successful pleurodesis and achieves long-term control with marked dyspnea decrease."

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Sclerosing Solutions (Sclerosing Agents)
3.	Doxycycline (Periostat)
4.	Powders
5.	Iodine
6.	Povidone-Iodine (Betadine)
7.	Minocycline (Cyclops)
8.	Pemetrexed (MTA)
9.	Thymidine Monophosphate (TMP)
10.	raltitrexed (D 1694)

Related Therapies and Procedures

1.	Pleurodesis
2.	Catheters
3.	Chest Tubes (Chest Tube)
4.	Thoracostomy
5.	Therapeutics