Cutaneous Syphilis (Syphilid)

Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409)

Also Known As:

Networked: 22 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Latent Syphilis
2.	Ulcer
3.	Coinfection
4.	Wounds and Injuries (Trauma)
5.	Warts (Wart)

Experts

1.	Fan, Yi-Ming: 1 article (01/2021)
2.	Huang, Zheng: 1 article (01/2021)
3.	Wang, Qi: 1 article (01/2021)
4.	Wu, Hao: 1 article (01/2021)
5.	Bauermeister, A: 1 article (05/2019)
6.	Campos, M L: 1 article (05/2019)
7.	De Grandis, R A: 1 article (05/2019)
8.	De Moraes, N V: 1 article (05/2019)
9.	Lopes, N P: 1 article (05/2019)
10.	Mauro, M: 1 article (05/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cutaneous Syphilis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 02/15/2011 - "Late cutaneous syphilis has become a rarity as a result of the effective treatment of early and latent syphilis with antibiotics. " 03/01/1997 - "Late cutaneous syphilis has become a rarity as a result of effective treatment of early and latent syphilis with antibiotics. "
2.	Penicillin G Benzathine (Benzathine Benzylpenicillin)FDA Link 12/01/1968 - "[Histochemical studies of syphilids during treatment with bicillin-4 and bicillin-6]."
3.	Penicillins (Penicillin)FDA Link 04/02/1948 - "Papilulose syphilid; relapsing peas penicillin treatment." 09/01/1946 - "Penicillin by mouth in the treatment of late cutaneous syphilis." 04/01/1951 - "[Early recurrent tuberculo-ulcerous syphilid following insufficient penicillin therapy]." 03/01/1948 - "Delayed syphilid from use of small doses of penicillin in cases of concurrently contracted mixed infection." 03/01/1986 - "The diagnosis was made without waiting for the hepatitis to respond to penicillin treatment, on the basis of the following signs: icterus involving inflammatory syndrome, moderate cytolysis, clear retention, eruption of papular syphilids and a strongly positive test for syphilis. "
4.	BismuthIBA 09/01/1966 - "[Results of the treatment of recent syphilids with bismuth alone]." 07/01/1959 - "The influence of penicillin-bismuth association in experimental syphilids]." 01/01/1972 - "[Tertiary cutaneous syphilis occurring after treatment with penicillin and bismuth]."
5.	Dexfenfluramine (Redux)IBA 01/01/2021 - "We describe a 17-year-old man who developed penile annular and scrotal eczematoid syphilids with penile chancre redux. " 01/01/2021 - "Penile annular and scrotal eczematoid syphilids with penile chancre redux."
6.	CortisoneFDA Link 03/01/1953 - "[Effect of cortisone on gummous syphilids and on the biologic syndrome of tabes]."
7.	Chlortetracycline (Aureomycin)FDA Link 05/25/1949 - "The oral use of aureomycin in the treatment of late cutaneous syphilis."
8.	Arsphenamine (Salvarsan)IBA 05/01/1912 - "SALVARSAN IN CUTANEOUS SYPHILIS."
9.	AntibodiesIBA 09/01/1998 - "The association between the antibodies and clinical manifestations (thrombosis, fetal loss, thrombocytopenia, biological false positive test for syphilis, cutaneous manifestations, central nervous system involvement, and renal involvement) was analyzed. "
10.	Local Anti-Infective Agents (Antiseptics)IBA 05/10/2019 - "Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use. "

Therapies and Procedures

1.	Traditional Medicine (Folk Remedies) 11/04/2016 - "and Schult.(Convolvulaceae), popularly known as salsa or salsa-brava, is a plant of which the decoction of leaves is used in folk medicine to treat various inflammatory disorders such of dermatitis, scabies, symptoms of syphilis, skin ulcers and external wounds. " 05/10/2019 - "Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use. "
2.	Aftercare (After-Treatment) 05/01/1978 - "After treatment for secondary syphilis in 1957 and retreatment for rising VDRL titers ten years later, one patient had developed a nodular syphilid. " 01/01/1972 - "[Tertiary cutaneous syphilis occurring after treatment with penicillin and bismuth]."
3.	Retreatment 05/01/1978 - "After treatment for secondary syphilis in 1957 and retreatment for rising VDRL titers ten years later, one patient had developed a nodular syphilid. "
4.	Thymectomy 08/01/1986 - "Strain 2 guinea pigs made T-cell deficient by thymectomy and irradiation and protected with syngeneic bone-marrow cells (TXB guinea pigs) have a surprisingly high level of resistance to cutaneous syphilis and to the dissemination of treponemes to the draining lymph node. "
5.	Therapeutics 04/01/1951 - "[Early recurrent tuberculo-ulcerous syphilid following insufficient penicillin therapy]."